The DOI matches its Crossref record; 125 of the 125 references it cites were found in a registry or an index.
The Role of Obesity in Type 2 Diabetes Mellitus—An Overview
Open accessAbstract
Obesity or excessive weight gain is identified as the most important and significant risk factor in the development and progression of type 2 diabetes mellitus (DM) in all age groups. It has reached pandemic dimensions, making the treatment of obesity crucial in the prevention and management of type 2 DM worldwide. Multiple clinical studies have demonstrated that moderate and sustained weight loss can improve blood glucose levels, insulin action and reduce the need for diabetic medications. A combined approach of diet, exercise and lifestyle modifications can successfully reduce obesity and subsequently ameliorate the ill effects and deadly complications of DM. This approach also helps largely in the prevention, control and remission of DM. Obesity and DM are chronic diseases that are increasing globally, requiring new approaches to manage and prevent diabetes in obese individuals. Therefore, it is essential to understand the mechanistic link between the two and design a comprehensive approach to increase life expectancy and improve the quality of life in patients with type 2 DM and obesity. This literature review provides explicit information on the clinical definitions of obesity and type 2 DM, the incidence and prevalence of type 2 DM in obese individuals, the indispensable role of obesity in the pathophysiology of type 2 DM and their mechanistic link. It also discusses clinical studies and outlines the recent management approaches for the treatment of these associated conditions. Additionally, in vivo studies on obesity and type 2 DM are discussed here as they pave the way for more rigorous development of therapeutic approaches.
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Cited by
Ahmed, S. K., & Mohammed, R. A. (2025) · Metabolism Open · doi:10.1016/j.metop.2025.100375 · Cited by 432
Effects of Probiotics on Gut Microbiota: An Overview
Chandrasekaran, P., Weiskirchen, S., & Weiskirchen, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms25116022 · Cited by 382
Self-citationAlzheimer’s disease as type 3 diabetes: understanding the link and implications
Kciuk, M., Kruczkowska, W., Gałęziewska, J., Wanke, K., Kałuzińska-Kołat, Ż., Aleksandrowicz, M., & Kontek, R. (2024) · International Journal of Molecular Sciences · doi:10.3390/ijms252211955 · Cited by 98
Tasabehji, D., Saleh, S., & Mokadem, M. (2025) · Journal of Clinical Medicine · doi:10.3390/jcm14124012 · Cited by 14
Lübker, C., Bhavsar, J., Duque do Vale, R., Emerson, S. S., Nørtoft, E., Plutzky, J., Roberts, G., Tarp, J. M., & Lincoff, A. M. (2025) · Advances in Therapy · doi:10.1007/s12325-025-03176-w · Cited by 5
Metadata
- Authors
- Chandrasekaran, P., & Weiskirchen, R.
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2024-02-04
- Volume
- 25
- Issue
- 3
- Pages
- 1882
- ISSN
- 1422-0067 (ISSN-L)
- OpenAlex
- W4391533471
- Cited by
- 465
- References
- 125
- FWCI
- 126.09
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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