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Cited by 57Hydrogels: synthesis, properties, applicationsCollagen: Extraction and CharacterizationPolysaccharides Composition and Applications

Hydrogels Based on Proteins Cross-Linked with Carbonyl Derivatives of Polysaccharides, with Biomedical Applications

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Mahmoudi, Chahrazed, Tahraoui Douma, Naïma, Mahmoudi, Hacene, Iurciuc (Tincu), Camelia Elena, Popa, Marcel·2024·International Journal of Molecular Sciences
DOI 10.3390/ijms25147839PMC PMC11277554
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Abstract

Adding carbonyl groups into the hydrogel matrix improves the stability and biocompatibility of the hydrogels, making them suitable for different biomedical applications. In this review article, we will discuss the use of hydrogels based on polysaccharides modified by oxidation, with particular attention paid to the introduction of carbonyl groups. These hydrogels have been developed for several applications in tissue engineering, drug delivery, and wound healing. The review article discusses the mechanism by which oxidized polysaccharides can introduce carbonyl groups, leading to the development of hydrogels through cross-linking with proteins. These hydrogels have tunable mechanical properties and improved biocompatibility. Hydrogels have dynamic properties that make them promising biomaterials for various biomedical applications. This paper comprehensively analyzes hydrogels based on cross-linked proteins with carbonyl groups derived from oxidized polysaccharides, including microparticles, nanoparticles, and films. The applications of these hydrogels in tissue engineering, drug delivery, and wound healing are also discussed.

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  • Hydrogels are widely applied in various biomedical applications due to their biological tissue-similar structure, biocompatibility, and tunable physical properties.

    “By virtue of their biological tissue-similar structure, biocompatibility, and tunable physical properties, hydrogels are widely applied in various biomedical applications [3,25,26].”

    From Mussel-Inspired Injectable Adhesive Hydrogels for Biomedical Applications (2024) · cites this paper as [26]

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Authors
Mahmoudi, C., Tahraoui Douma, N., Mahmoudi, H., Iurciuc (Tincu), C. E., & Popa, M.
Affiliations
  • Gheorghe Asachi Technical University of Iași (RO)
  • Laboratory of Water and Environment, Faculty of Technology, University Hassiba Benbouali of Chlef, Chlef 02000, Algeria
  • National Higher School of Nanosciences and Nanotechnologies, Algiers 16000, Algeria
  • Department of Natural and Synthetic Polymers, Faculty of Chemical Engineering and Protection of the Environment, “Gheorghe Asachi” Technical University, 700050 Iasi, Romania
  • Academia Oamenilor de Știință din România (RO)
Corresponding author
Popa, Marcel
ORCID
Popa, Marcel
Venue
International Journal of Molecular Sciences
Publisher
MDPI AG
Published
2024-07-17
Volume
25
Issue
14
Pages
7839
ISSN
1422-0067 (ISSN-L)
DOI
10.3390/ijms25147839
PMC
PMC11277554
OpenAlex
W4400778150
Cited by
57
References
1
Citations by year
2026: 25 · 2025: 27 · 2024: 5
FWCI
1.64
Type
journal article
Language
en
Open access
Licence
Locations
  • International Journal of Molecular Sciences (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
Funders
Universitatea Tehnică „Gheorghe Asachi” din Iaşi
Topics
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Biomaterials › Collagen: Extraction and Characterization
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Polysaccharides Composition and Applications
Keywords
carbonyl compounds, polysaccharide oxidation, protein cross-linking, hydrogel biocompatibility, hydrogel mechanical properties, tissue engineering, drug delivery, wound healing, microparticles, nanoparticles, cinema, dynamic hydrogels
MeSH terms
Animals, Biocompatible Materials, Cross-Linking Reagents, Humans, Oxidation-Reduction, Polysaccharides, Proteins, Wound Healing, Drug Delivery Systems, Hydrogels, Tissue Engineering

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