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Extraction of Glycyrrhizic Acid and Glabridin from Licorice
Open accessAbstract
The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50°C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.
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“Indeed a mixture of ethanol/water (30:70, v/v) used for an extraction time of 60 min under 50 • C of licorice gave a high recovery of glabridin (72.5%) [28].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [28]
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Metadata
- Authors
- Tian, M., Yan, H., & Row, K. H.
- Affiliations
- Inha University (KR)
- Corresponding author
- Row, Kyung Ho
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2008-04-16
- Volume
- 9
- Issue
- 4
- Pages
- 571-577
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC2635700
- OpenAlex
- W2098013424
- Cited by
- 133
- References
- 11
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Inha University
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Keywords
- glycyrrhizin, glabridin, licorice, extraction optimization, ethanol-water solvent, reversed-phase HPLC, saponins, triterpenoids
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