Cited by 133Pharmacological Effects of Natural CompoundsTraditional Chinese Medicine AnalysisChromatography in Natural Products

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Extraction of Glycyrrhizic Acid and Glabridin from Licorice

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Tian, Minglei, Yan, Hongyuan, Row, Kyung Ho·2008·International Journal of Molecular Sciences

DOI 10.3390/ijms9040571PMC PMC2635700

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Abstract

The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50°C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.

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Authors: Tian, M., Yan, H., & Row, K. H.
Affiliations: Inha University (KR)
Corresponding author: Row, Kyung Ho
ORCID: Tian, Minglei
Yan, Hongyuan
Row, Kyung Ho
Venue: International Journal of Molecular Sciences
Publisher: MDPI AG
Published: 2008-04-16
Volume: 9
Issue: 4
Pages: 571-577
ISSN: 1422-0067 (ISSN-L)
DOI: 10.3390/ijms9040571
PMC: PMC2635700
OpenAlex: W2098013424
Cited by: 133
References: 11
Citations by year: 2026: 8 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
FWCI: 3.64
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: International Journal of Molecular Sciences (publishedVersion, cc-by)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: Inha University
Topics: Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
Keywords: glycyrrhizin, glabridin, licorice, extraction optimization, ethanol-water solvent, reversed-phase HPLC, saponins, triterpenoids

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Extraction of Glycyrrhizic Acid and Glabridin from Licorice

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