The DOI matches its Crossref record; 11 of the 11 references it cites were found in a registry or an index.
Extraction of Glycyrrhizic Acid and Glabridin from Licorice
Open accessAbstract
The extraction and separation conditions of glycyrrhizic acid and glabridin from licorice were investigated. By changing the different extraction solvents, procedures, times and temperature, the optimum extraction condition was established: the used of ethanol/water (30:70, v/v) as an extraction solvent, and 60 min dipping time under 50°C. The extracts of licorice were separated and determined by reversed-phase high performance liquid chromatography with a methanol/water (70:30, v/v, containing 1% acetic acid) as the mobile phase. Under the optimum extraction condition, 2.39 mg/g of glycyrrhizic acid and 0.92 mg/g of glabridin were extracted from Chinese licorice and the recoveries were 89.7% and 72.5% respectively.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The cited source says what the claim attributes to it.
In the citing paper
“Indeed a mixture of ethanol/water (30:70, v/v) used for an extraction time of 60 min under 50 • C of licorice gave a high recovery of glabridin (72.5%) [28].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [28]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Glycyrrhizin, an active component of liquorice roots, and replication of SARS-associated coronavirus
Cinátl, J., Morgenstern, B., Bauer, G., Chandra, P., Rabenau, H. F., & Hw, D. (2003) · The Lancet · doi:10.1016/s0140-6736(03)13615-x · Cited by 1,175
The application of macroporous resins in the separation of licorice flavonoids and glycyrrhizic acid
Fu, B., Liu, J., Li, H., Li, L., Lee, S., & Wang, X. (2005) · Journal of Chromatography A · doi:10.1016/j.chroma.2005.06.051 · Cited by 178
Fukai, T., Satoh, K., Nomura, T., & Sakagami, H. (2003) · Fitoterapia · doi:10.1016/s0367-326x(03)00164-3 · Cited by 132
Fujisawa, Y., Sakamoto, M., Matsushita, M., Fujita, T., & Nishioka, K. (2000) · Microbiology and Immunology · doi:10.1111/j.1348-0421.2000.tb02566.x · Cited by 97
Cherng, J., Lin, H. J., Hung, M.-S., Lin, Y.-R., Chan, M., & Lin, J. (2006) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2006.06.080 · Cited by 84
The licorice root derived isoflavan glabridin increases the function of osteoblastic MC3T3-E1 cells
Choi, E. (2005) · Biochemical Pharmacology · doi:10.1016/j.bcp.2005.04.019 · Cited by 74
Glycyrrhizic acid suppresses type 2 11β-hydroxysteroid dehydrogenase expression in vivo
Tanahashi, T., Mune, T., Morita, H., Tanahashi, H., Isomura, Y., Suwa, T., Daido, H., Gómez-Sánchez, C. E., & Yasuda, K. (2002) · The Journal of Steroid Biochemistry and Molecular Biology · doi:10.1016/s0960-0760(02)00033-x · Cited by 59
Acharya, S. K., Dasarathy, S., Tandon, A., Joshi, Y., & Tandon, B. N. (1993) · PubMed · Cited by 56
Determination of glabridin in human plasma by solid-phase extraction and LC–MS/MS
Aoki, F., NAKAGAWA, K., Tanaka, A., MATSUZAKI, K., ARAI, N., & MAE, T. (2005) · Journal of Chromatography B · doi:10.1016/j.jchromb.2005.09.012 · Cited by 54
Dehpour, A. R., Zolfaghari, M., Samadian, T., Kobarfard, F., Faizi, M., & Assari, M. (1995) · International Journal of Pharmaceutics · doi:10.1016/0378-5173(94)00377-h · Cited by 44
Ito, A., Hayashi, N., KATAYAMA, K., Hagiwara, H., Kasahara, A., KASHIWAGI, T., Yoshihara, H., Fusamoto, H., & Kamada, T. (1997) · International Hepatology Communications · doi:10.1016/s0928-4346(97)00351-4 · Cited by 18
Cited by
Sorted by citations
Modeling of Experimental Adsorption Isotherm Data
Chen, X. (2015) · Information · doi:10.3390/info6010014 · Cited by 550
Phytochemistry and biological properties of glabridin
Simmler, C., Pauli, G. F., & Chen, S.-N. (2013) · Fitoterapia · doi:10.1016/j.fitote.2013.07.003 · Cited by 281
Egyptian licorice extract as a green corrosion inhibitor for copper in hydrochloric acid solution
Deyab, M. A. M. (2014) · Journal of Industrial and Engineering Chemistry · doi:10.1016/j.jiec.2014.07.036 · Cited by 169
Sharifi‐Rad, J., Quispe, C., Herrera‐Bravo, J., Belén, L. H., Kaur, R., Kręgiel, D., Uprety, Y., Beyatlı, A., Yeskaliyeva, B. K., Kırkın, C., et al. (2021) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2021/7571132 · Cited by 137
The potential of glycyrrhizin and licorice extract in combating COVID-19 and associated conditions
Gomaa, A. A., & Abdel-Wadood, Y. A. (2021) · Phytomedicine Plus · doi:10.1016/j.phyplu.2021.100043 · Cited by 101
Metadata
- Authors
- Tian, M., Yan, H., & Row, K. H.
- Affiliations
- Inha University (KR)
- Corresponding author
- Row, Kyung Ho
- Venue
- International Journal of Molecular Sciences
- Publisher
- MDPI AG
- Published
- 2008-04-16
- Volume
- 9
- Issue
- 4
- Pages
- 571-577
- ISSN
- 1422-0067 (ISSN-L)
- PMC
- PMC2635700
- OpenAlex
- W2098013424
- Cited by
- 133
- References
- 11
- Citations by year
- 2026: 8 · 2025: 8 · 2024: 11 · 2023: 10 · 2022: 15 · 2021: 14 · 2020: 9 · 2019: 11 · 2018: 5 · 2017: 9 · 2016: 5 · 2015: 3 · 2014: 5 · 2013: 5 · 2012: 3
- FWCI
- 3.64
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Molecular Sciences (publishedVersion, cc-by)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- Inha University
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Health Sciences › Medicine › Complementary and alternative medicine › Traditional Chinese Medicine Analysis
- Physical Sciences › Chemistry › Analytical Chemistry › Chromatography in Natural Products
- Keywords
- glycyrrhizin, glabridin, licorice, extraction optimization, ethanol-water solvent, reversed-phase HPLC, saponins, triterpenoids
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
