The DOI matches its Crossref record; 60 of the 60 references it cites were found in a registry or an index.
The Role of Antioxidants on Wound Healing: A Review of the Current Evidence
Open accessAbstract
(1) Background: Reactive oxygen species (ROS) play a crucial role in the preparation of the normal wound healing response. Therefore, a correct balance between low or high levels of ROS is essential. Antioxidant dressings that regulate this balance are a target for new therapies. The purpose of this review is to identify the compounds with antioxidant properties that have been tested for wound healing and to summarize the available evidence on their effects. (2) Methods: A literature search was conducted and included any study that evaluated the effects or mechanisms of antioxidants in the healing process (in vitro, animal models or human studies). (3) Results: Seven compounds with antioxidant activity were identified (Curcumin, N-acetyl cysteine, Chitosan, Gallic Acid, Edaravone, Crocin, Safranal and Quercetin) and 46 studies reporting the effects on the healing process of these antioxidants compounds were included. (4) Conclusions: this review offers a map of the research on some of the antioxidant compounds with potential for use as wound therapies and basic research on redox balance and oxidative stress in the healing process. Curcumin, NAC, quercetin and chitosan are the antioxidant compounds that shown some initial evidence of efficacy, but more research in human is needed.
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Cites
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Cited by
Hassaninejad Farahani, F., Moraffah, F., Samadi, N., Sharifzadeh, M., Motasadizadeh, H., & Vatanara, A. (2023) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2023.122800 · Cited by 20
Ayoub, N., Badr, N., Al-Ghamdi, S. S., Alsanosi, S., Alzahrani, A. R., Abdel-Naim, A. B., Nematallah, K. A., & Swilam, N. (2021) · Nutrients · doi:10.3390/nu14010028 · Cited by 19
Metadata
- Authors
- Comino-Sanz, I. M., López-Franco, M. D., Castro, B., & Pancorbo-Hidalgo, P. L.
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2021-08-13
- Volume
- 10
- Issue
- 16
- Pages
- 3558
- ISSN
- 2077-0383 (ISSN-L)
- OpenAlex
- W3194894421
- Cited by
- 412
- References
- 60
- FWCI
- 24.86
- Type
- journal article
- Language
- en
- Open access
- gold
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- Comino-Sanz, I. M., López-Franco, M. D., Castro, B., & Pancorbo-Hidalgo, P. L. (2021). The Role of Antioxidants on Wound Healing: A Review of the Current Evidence. Journal of Clinical Medicine. https://doi.org/10.3390/jcm10163558
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
