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Cited by 1,380

The DOI matches its Crossref record; 61 of the 61 references it cites were found in a registry or an index.

Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process

Open access
Dunnill, Christopher, Patton, Thomas, Brennan, James, Barrett, John, Dryden, Matthew, Cooke, Jonathan, Leaper, David, Georgopoulos, Nikolaos T·2017·International Wound Journal
DOI 10.1111/iwj.12557
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Abstract

Reactive oxygen species (ROS) play a pivotal role in the orchestration of the normal wound‐healing response. They act as secondary messengers to many immunocytes and non‐lymphoid cells, which are involved in the repair process, and appear to be important in coordinating the recruitment of lymphoid cells to the wound site and effective tissue repair. ROS also possess the ability to regulate the formation of blood vessels (angiogenesis) at the wound site and the optimal perfusion of blood into the wound‐healing area. ROS act in the host's defence through phagocytes that induce an ROS burst onto the pathogens present in wounds, leading to their destruction, and during this period, excess ROS leakage into the surrounding environment has further bacteriostatic effects. In light of these important roles of ROS in wound healing and the continued quest for therapeutic strategies to treat wounds in general and chronic wounds, such as diabetic foot ulcers, venous and arterial leg ulcers and pressure ulcers in particular, the manipulation of ROS represents a promising avenue for improving wound‐healing responses when they are stalled. This article presents a review of the evidence supporting the critical role of ROS in wound healing and infection control at the wound site, and some of the new emerging concepts associated with ROS modulation and its potential in improving wound healing are discussed.

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Research works printed but not linked: 4

  1. Held P, 2010, An introduction to reactive oxygen species‐measurement of ROS in cells
  2. 10.1016/0190-9622(95)90238-4 · doi:10.1016/0190-9622(95)90238-4
  3. Dryden M, 2013, Surgihoney – honey wound treatment: first report of in‐vitro activity and early clinical evaluation
  4. 10.1186/s13104-014-0960-4 · doi:10.1186/s13104-014-0960-4

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Metadata

Authors
Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D., & Georgopoulos, N. T.
Venue
International Wound Journal
Publisher
Wiley
Published
2015-12-21
Volume
14
Issue
1
Pages
89-96
ISSN
  • 1742-4801 (ISSN-L)
  • 1742-481X
DOI
10.1111/iwj.12557
OpenAlex
W2220643393
Cited by
1,380
References
61
FWCI
22.29
Type
journal article
Language
en
Open access
green
Licence
onlinelibrary.wiley.com/termsAndConditions#vor (vor)

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CoChat. (2026). Citation check: Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process. https://app.cochat.ai/papers/10.1111/iwj.12557
The paper
Dunnill, C., Patton, T., Brennan, J., Barrett, J., Dryden, M., Cooke, J., Leaper, D., & Georgopoulos, N. T. (2017). Reactive oxygen species (ROS) and wound healing: the functional role of ROS and emerging ROS‐modulating technologies for augmentation of the healing process. International Wound Journal. https://doi.org/10.1111/iwj.12557

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.