Instant Detection of Cerebral Blood Flow Changes in Infants with Congenital Heart Disease during Transcatheter Interventions
Open accessAbstract
Background: Transcatheter interventions are increasingly used in children with congenital heart disease. However, these interventions can affect cardiac output and cerebral circulation. In this pilot study, we aimed to investigate the use of NeoDoppler, a continuous transfontanellar cerebral Doppler monitoring system, to evaluate the impact of transcatheter interventions on cerebral circulation. Methods: Nineteen participants under one year of age (mean age 3.5 months) undergoing transcatheter cardiac interventions were prospectively included. Transfontanellar cerebral Doppler monitoring with the NeoDoppler system was initiated after intubation and continued until the end of the procedure. Results: Instant detection of changes in cerebral blood flow were observed across a spectrum of transcatheter interventions. Balloon aortic valvuloplasty demonstrated temporary cessation of cerebral blood flow during balloon inflation. Increase in cerebral diastolic blood flow velocity and decreased pulsatility were observed during patent ductus arteriosus occlusion. Changes in cerebral blood flow patterns were detected in two patients who encountered complications during their transcatheter interventions. There was no significant change in Doppler parameters before and after the interventions for the entire patient group. High quality recordings were achieved in 87.3% of the monitoring period. Conclusions: Continuous transfontanellar cerebral Doppler is feasible in monitoring cerebral hemodynamic trends and shows instantaneous changes associated with interventions and complications. It could become a useful monitoring tool during transcatheter interventions in infants.
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The authors concluded that NeoDoppler may aid both anesthesiologists and interventional cardiologists by identifying early signs of neurologic or hemodynamic instability.
“The authors concluded that NeoDoppler may aid both anesthesiologists and interventional cardiologists by identifying early signs of neurologic or hemodynamic instability.”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [63]
The Conclusions say the monitoring could be useful to interventionists and anesthesiologists and can display immediate changes associated with hemodynamically significant interventions or complications. Discussion §4.2 likewise describes immediate Doppler changes during complications. The paper does not establish that these changes identify early signs of neurologic instability; §4.4 notes the lack of neurocognitive follow-up or cerebral MRI. (LLM, conf=0.82)
Experimental — accuracy not yet measuredIn a small, single-center study by Olsen et al., NeoDoppler was found to be a potentially valuable tool for real-time cerebral monitoring during transcatheter interventions in infants with CHD.
“In a small, single-center study by Olsen et al., this technology was found to be a potentially valuable tool for real-time cerebral monitoring during transcatheter interventions in infants with CHD [63].”
From Trends and Challenges in Noninvasive Hemodynamic Monitoring of Neonates Following Cardiac Surgery: A Narrative Review (2025) · cites this paper as [63]
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“In a small, single-center study by Olsen et al., this technology was found to be a potentially valuable tool for real-time cerebral monitoring during transcatheter interventions in infants with CHD [63].”
- Authors
- Leth-Olsen, M., Døhlen, G., Torp, H., & Nyrnes, S. A.
- Affiliations
- Norwegian University of Science and Technology (NO)
- Oslo University Hospital (NO)
- Corresponding author
- Leth-Olsen, Martin
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2024-05-26
- Volume
- 13
- Issue
- 11
- Pages
- 3115
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC11172647
- OpenAlex
- W4399055059
- Cited by
- 1
- References
- 27
- Citations by year
- 2025: 1
- FWCI
- 0.31
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- NORA - Norwegian Open Research Archives (submittedVersion, cc-by)
- Funders
- Research Council of Norway (260699/O30, 2017/38297, 2018/42794, 2018/115, 8/18)
- Liaison Committee for education, research, and innovation in Central Norway (260699/O30, 2017/38297, 2018/42794, 2018/115, 8/18)
- Norwegian Association for Children with Congenital Heart Disease’s Research Foundation (260699/O30, 2017/38297, 2018/42794, 2018/115, 8/18)
- Heart Foundation, St Olav’s University Hospital’s gift foundation (260699/O30, 2017/38297, 2018/42794, 2018/115, 8/18)
- Topics
- Health Sciences › Medicine › Epidemiology › Congenital Heart Disease Studies
- Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Cardiovascular Conditions and Treatments
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Cardiovascular and Diving-Related Complications
- Keywords
- cerebral blood flow, congenital heart disease, infants, transcatheter interventions, balloon aortic valvuloplasty, cerebral hemodynamics, procedural complications, cardiac output
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