Environment and Male Fertility: Effects of Benzo-α-Pyrene and Resveratrol on Human Sperm Function In Vitro
Open accessAbstract
Lifestyle, cigarette smoking and environmental pollution have a negative impact on male fertility. Therefore, the aim of this study was to evaluate the in-vitro effects of benzo-α-pyrene (BaP) and aryl hydrocarbon receptor (AHR) agonists on motility and bio-functional sperm parameters. We further assessed whether resveratrol (RES), an AHR antagonist and antioxidant molecule, had any protective effect. To accomplish this, 30 normozoospermic, healthy, non-smoker men not exposed to BaP were enrolled. Spermatozoa of 15 men were incubated with increasing concentrations of BaP to evaluate its effect and to establish its dose response. Then, spermatozoa of the 15 other men were incubated with BaP (15 µM/mL), chosen according to the dose-response and/or RES to evaluate its antagonistic effects. The effects of both substances were evaluated after 3 h of incubation on total and progressive sperm motility and on the following bio-functional sperm parameters evaluated by flow cytometry: Degree of chromatin compactness, viability, phosphatidylserine externalization (PS), late apoptosis, mitochondrial membrane potential (MMP), DNA fragmentation, degree of lipoperoxidation (LP), and concentrations of mitochondrial superoxide anion. Benzo-α-pyrene decreased total and progressive sperm motility, impaired chromatin compactness, and increased sperm lipoperoxidation and mitochondrial superoxide anion levels. All these effects were statistically significant at the lowest concentration tested (15 µM/mL) and they were confirmed at the concentration of 45 µM/mL. In turn, RES was able to counteract the detrimental effects of BaP on sperm motility, abnormal chromatin compactness, lipid peroxidation, and mitochondrial superoxide. This study showed that BaP alters sperm motility and bio-functional sperm parameters and that RES exerts a protective effect on BaP-induced sperm damage.
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Resveratrol has anti-inflammatory effects.
“This polyphenol also has anti-inflammatory effects. In fact, it inhibits cyclooxygenase-2 (COX-2), nuclear factor-kB (NF-kB), and other molecules involved in inflammatory processes [6,8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [6]
Resveratrol inhibits COX-2, NF-kB, and other molecules involved in inflammatory processes.
“In fact, it inhibits cyclooxygenase-2 (COX-2), nuclear factor-kB (NF-kB), and other molecules involved in inflammatory processes [6,8].”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [6]
Resveratrol has cytoprotective effects.
“Resveratrol also has cytoprotective effects and antioxidant properties, and modulates anti- and pro-apoptotic mediators, protecting cells from DNA damage.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [6]
Resveratrol has antioxidant properties.
“This polyphenol has anticancer and antioxidant properties and cytoprotective and anti-inflammatory effects.”
From The Role of Resveratrol Administration in Human Obesity (2021) · cites this paper as [6]
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- Authors
- Alamo, A., Condorelli, R. A., Mongioì, L. M., Cannarella, R., Giacone, F., Calabrese, V., La Vignera, S., & Calogero, A. E.
- Affiliations
- Department of Clinical and Experimental Medicine, 95123 Catania, Italy
- University of Catania (IT)
- Corresponding author
- Calogero, Aldo E.
- ORCID
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2019-04-25
- Volume
- 8
- Issue
- 4
- Pages
- 561
- ISSN
- 2077-0383 (ISSN-L)
- PMC
- PMC6518055
- OpenAlex
- W2940454151
- Cited by
- 58
- References
- 50
- Citations by year
- 2025: 5 · 2024: 11 · 2023: 8 · 2022: 8 · 2021: 18 · 2020: 7 · 2019: 1
- FWCI
- 8.13
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Journal of Clinical Medicine (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Reproductive Medicine › Sperm and Testicular Function
- Physical Sciences › Environmental Science › Health, Toxicology and Mutagenesis › Effects and risks of endocrine disrupting chemicals
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Physiology › Reproductive biology and impacts on aquatic species
- Keywords
- resveratrol, male fertility, sperm motility, aryl hydrocarbon receptor agonists, sperm DNA fragmentation, lipid peroxidation, mitochondrial superoxide, sperm viability, environmental pollution
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