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Cited by 36

The DOI matches its Crossref record; 7 of the 7 references it cites were found in a registry or an index.

Cardiac and Vascular Sympathetic Baroreflex Control during Orthostatic Pre-Syncope

Furlan, Raffaello, Heusser, Karsten, Minonzio, Maura, Shiffer, Dana, Cairo, Beatrice, Tank, Jens, Jordan, Jens, Diedrich, André, Gauger, Peter, Zamuner, Antonio Roberto, Dipaola, Franca, Porta, Alberto, Barbic, Franca·2019·Journal of Clinical Medicine
DOI 10.3390/jcm8091434
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Abstract

We hypothesized that sympathetic baroreflex mediated uncoupling between neural sympathetic discharge pattern and arterial pressure (AP) fluctuations at 0.1 Hz during baroreceptor unloading might promote orthostatic pre-syncope. Ten volunteers (32 ± 6 years) underwent electrocardiogram, beat-to-beat AP, respiratory activity and muscle sympathetic nerve activity (MSNA) recordings while supine (REST) and during 80° head-up tilt (HUT) followed by −10 mmHg stepwise increase of lower body negative pressure until pre-syncope. Cardiac and sympathetic baroreflex sensitivity were quantified. Spectrum analysis of systolic and diastolic AP (SAP and DAP) and calibrated MSNA (cMSNA) variability assessed the low frequency fluctuations (LF, ~0.1 Hz) of SAP, DAP and cMSNA variability. The squared coherence function (K2) quantified the coupling between cMSNA and DAP in the LF band. Analyses were performed while supine, during asymptomatic HUT (T1) and at pre-syncope onset (T2). During T2 we found that: (1) sympathetic baroreceptor modulation was virtually abolished compared to T1; (2) a progressive decrease in AP was accompanied by a persistent but chaotic sympathetic firing; (3) coupling between cMSNA and AP series at 0.1 Hz was reduced compared to T1. A negligible sympathetic baroreceptor modulation during pre-syncope might disrupt sympathetic discharge pattern impairing the capability of vessels to constrict and promote pre-syncope.

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Cited by

Metadata

Authors
Furlan, R., Heusser, K., Minonzio, M., Shiffer, D., Cairo, B., Tank, J., Jordan, J., Diedrich, A., Gauger, P., Zamuner, A. R., Dipaola, F., Porta, A., & Barbic, F.
Affiliations
  • Department of Internal Medicine, Humanitas Clinical and Research Center, IRCCS, Humanitas University, 20089 Rozzano, Italy
  • Institute of Aerospace Medicine, German Aerospace Center (DLR), 51147 Cologne, Germany
  • Department of Biomedical Sciences for Health, University of Milan, 20122 Milan, Italy
  • Autonomic Dysfunction Center, Vanderbilt University Medical Center, Nashville, TN 37232, USA
  • Departamento de Kinesiología, Universidad Católica del Maule, 3530000 Talca, Maule, Chile
ORCID
Venue
Journal of Clinical Medicine
Publisher
MDPI AG
Published
2019-09-10
Volume
8
Issue
9
Pages
1434
ISSN
2077-0383
DOI
10.3390/jcm8091434
Cited by
36
References
7
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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