Work ability assessment and its relationship with cardiovascular autonomic profile in postural orthostatic tachycardia syndrome
Open accessAbstract
Postural orthostatic tachycardia syndrome (POTS) negatively impacts quality of life. The excessive increase in cardiac sympathetic modulation during standing, which characterizes POTS patients, leads to many symptoms and signs of orthostatic intolerance. Little is known about the consequences of the disease on work performance and its relationship with individual autonomic profiles. Twenty-two POTS patients regularly engaged in working activity (20 females, age 36 ± 12 years) and 18 gender- and age-matched controls underwent a clinical evaluation and filled out the Work Ability Index (WAI) questionnaire. POTS patients completed the Composite Autonomic Symptom Score (COMPASS31) questionnaire, underwent continuous electrocardiogram, blood pressure and respiratory activity recordings while supine and during a 75° head-up tilt (HUT). A power spectrum analysis provided the index of cardiac sympatho-vagal balance (LF/HF). WAI scores were significantly reduced in POTS patients (29.84 ± 1.40) compared to controls (45.63 ± 0.53, p < 0.01). A significant inverse correlation was found between individual WAI and COMPASS31 scores (r = −0.46; p = 0.03), HUT increase in heart rate (r = −0.57; p = 0.01) and LF/HF (r = −0.55; p = 0.01). In POTS patients, the WAI scores were inversely correlated to the intensity of autonomic symptoms and to the excessive cardiac sympathetic activation induced by the gravitational stimulus.
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In working POTS patients, total autonomic symptom scores (COMPASS31) had a significant medium negative correlation with Work Ability Index scores.
“found that a significant medium correlation was present between total autonomic symptom scores (COMPASS31) and Work Ability Index (WAI, an instrument which assesses the perceived ability to work) scores. The higher the total COMPASS31 score the lower the WAI score”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Barbic et al., 2020
WAI scores were significantly lower in people with POTS compared to healthy controls.
“WAI scores were significantly lower in people with POTS compared to healthy controls (Barbic et al., 2020”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Barbic et al., 2020
Studies using the COMPASS31 showed people with POTS report a wide range of autonomic symptoms of moderate to severe intensity.
“Studies using the COMPASS31, showed people with POTS also report a wide range of autonomic symptoms of moderate to severe intensity”
From Self-reported symptom burden in postural orthostatic tachycardia syndrome (POTS): A narrative review of observational and interventional studies (2023) · cites this paper as Barbic et al., 2020
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Solastalgia as a Neglected Psychosocial Stressor in Later-Life Aging Under Environmental Change
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Self-citationAutonomic neuropathy improving after intravenous immunoglobulin therapy
Alberti, C., Spagliardi, J., Barbic, F., Doneddu, P. E., Cutellé, C., Furlan, R., & Nobile‐Orazio, E. (2024) · Clinical Autonomic Research · doi:10.1007/s10286-024-01034-3
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Andrade, C., Zamuner, A., Barbic, F., Porta, A., Rigo, S., Shiffer, D., Bringard, A., Fagoni, N., Guido, F., & Furlan, R. (2026) · Zenodo (CERN European Organization for Nuclear Research) · doi:10.5281/zenodo.20327113
Self-citation
- Authors
- Barbic, F., Minonzio, M., Cairo, B., Shiffer, D., Zamuner, A. R., Cavalieri, S., Dipaola, F., Magnavita, N., Porta, A., & Furlan, R.
- Affiliations
- Humanitas University (IT)
- IRCCS Humanitas Research Hospital (IT)
- University of Milan (IT)
- Departamento de Kinesiología, Universidad Católica del Maule, 3480112 Talca, Maule, Chile
- Università Cattolica del Sacro Cuore (IT)
- Corresponding author
- Barbic, Franca
- ORCID
- Venue
- International Journal of Environmental Research and Public Health
- Publisher
- MDPI AG
- Published
- 2020-10-26
- Volume
- 17
- Issue
- 21
- Pages
- 7836
- ISSN
- 1660-4601 (ISSN-L)
- PMC
- PMC7662324
- OpenAlex
- W3097094244
- Cited by
- 29
- References
- 65
- Citations by year
- 2026: 1 · 2025: 6 · 2024: 10 · 2023: 3 · 2022: 3 · 2021: 6
- FWCI
- 2.74
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- RePEc: Research Papers in Economics (submittedVersion)
- Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
- Funders
- Italian Ministry of Health (# RF-2013-02355242)
- Topics
- Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
- Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
- Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
- Keywords
- postural orthostatic tachycardia syndrome, work ability, Work Ability Index, cardiac autonomic dysfunction, sympathovagal balance, heart rate variability, head-up tilt, orthostatic intolerance, autonomic symptoms, employee performance
- MeSH terms
- Adult, Blood Pressure, Electrocardiography, Female, Heart Rate, Humans, Male, Middle Aged, Posture, Quality of Life, Work Capacity Evaluation, Postural Orthostatic Tachycardia Syndrome
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