Cited by 29Cardiovascular Syncope and Autonomic DisordersHeart Rate Variability and Autonomic ControlLong-Term Effects of COVID-19

Work ability assessment and its relationship with cardiovascular autonomic profile in postural orthostatic tachycardia syndrome

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Barbic, Franca, Minonzio, Maura, Cairo, Beatrice, Shiffer, Dana, Zamuner, Antonio Roberto, Cavalieri, Silvia, Dipaola, Franca, Magnavita, Nicola +2 more·2020·International Journal of Environmental Research and Public Health

Abstract

Postural orthostatic tachycardia syndrome (POTS) negatively impacts quality of life. The excessive increase in cardiac sympathetic modulation during standing, which characterizes POTS patients, leads to many symptoms and signs of orthostatic intolerance. Little is known about the consequences of the disease on work performance and its relationship with individual autonomic profiles. Twenty-two POTS patients regularly engaged in working activity (20 females, age 36 ± 12 years) and 18 gender- and age-matched controls underwent a clinical evaluation and filled out the Work Ability Index (WAI) questionnaire. POTS patients completed the Composite Autonomic Symptom Score (COMPASS31) questionnaire, underwent continuous electrocardiogram, blood pressure and respiratory activity recordings while supine and during a 75° head-up tilt (HUT). A power spectrum analysis provided the index of cardiac sympatho-vagal balance (LF/HF). WAI scores were significantly reduced in POTS patients (29.84 ± 1.40) compared to controls (45.63 ± 0.53, p < 0.01). A significant inverse correlation was found between individual WAI and COMPASS31 scores (r = −0.46; p = 0.03), HUT increase in heart rate (r = −0.57; p = 0.01) and LF/HF (r = −0.55; p = 0.01). In POTS patients, the WAI scores were inversely correlated to the intensity of autonomic symptoms and to the excessive cardiac sympathetic activation induced by the gravitational stimulus.

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Authors
Barbic, F., Minonzio, M., Cairo, B., Shiffer, D., Zamuner, A. R., Cavalieri, S., Dipaola, F., Magnavita, N., Porta, A., & Furlan, R.
Affiliations
  • Humanitas University (IT)
  • IRCCS Humanitas Research Hospital (IT)
  • University of Milan (IT)
  • Departamento de Kinesiología, Universidad Católica del Maule, 3480112 Talca, Maule, Chile
  • Università Cattolica del Sacro Cuore (IT)
Corresponding author
Barbic, Franca
Venue
International Journal of Environmental Research and Public Health
Publisher
MDPI AG
Published
2020-10-26
Volume
17
Issue
21
Pages
7836
ISSN
1660-4601 (ISSN-L)
OpenAlex
W3097094244
Cited by
29
References
65
Citations by year
2026: 1 · 2025: 6 · 2024: 10 · 2023: 3 · 2022: 3 · 2021: 6
FWCI
2.74
Type
journal article
Language
en
Open access
Locations
  • International Journal of Environmental Research and Public Health (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • RePEc: Research Papers in Economics (submittedVersion)
  • Archivio Istituzionale della Ricerca (Universita Degli Studi Di Milano) (submittedVersion, other-oa)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
  • PubliCatt (Università Cattolica del Sacro Cuore) (submittedVersion, cc-by)
Funders
Italian Ministry of Health (# RF-2013-02355242)
Topics
  • Health Sciences › Medicine › Surgery › Cardiovascular Syncope and Autonomic Disorders
  • Health Sciences › Medicine › Cardiology and Cardiovascular Medicine › Heart Rate Variability and Autonomic Control
  • Health Sciences › Medicine › Neurology › Long-Term Effects of COVID-19
Keywords
postural orthostatic tachycardia syndrome, work ability, Work Ability Index, cardiac autonomic dysfunction, sympathovagal balance, heart rate variability, head-up tilt, orthostatic intolerance, autonomic symptoms, employee performance
MeSH terms
Adult, Blood Pressure, Electrocardiography, Female, Heart Rate, Humans, Male, Middle Aged, Posture, Quality of Life, Work Capacity Evaluation, Postural Orthostatic Tachycardia Syndrome

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