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Hypertension, Thrombosis, Kidney Failure, and Diabetes: Is COVID-19 an Endothelial Disease? A Comprehensive Evaluation of Clinical and Basic Evidence
Open accessAbstract
The symptoms most commonly reported by patients affected by coronavirus disease (COVID-19) include cough, fever, and shortness of breath. However, other major events usually observed in COVID-19 patients (e.g., high blood pressure, arterial and venous thromboembolism, kidney disease, neurologic disorders, and diabetes mellitus) indicate that the virus is targeting the endothelium, one of the largest organs in the human body. Herein, we report a systematic and comprehensive evaluation of both clinical and preclinical evidence supporting the hypothesis that the endothelium is a key target organ in COVID-19, providing a mechanistic rationale behind its systemic manifestations.
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Cited by
Vertical transmission of coronavirus disease 2019: a systematic review and meta-analysis
Kotlyar, A. M., Grechukhina, O., Chen, A., Popkhadze, S., Grimshaw, A., Tal, O., Taylor, H. S., & Tal, R. (2021) · American Journal of Obstetrics and Gynecology · doi:10.1016/j.ajog.2020.07.049 · Cited by 666
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COVID-19, immunothrombosis and venous thromboembolism: biological mechanisms
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Arginine and Endothelial Function
Gambardella, J., Khondkar, W., Morelli, M. B., Wang, X., Santulli, G., & Trimarco, V. (2020) · Biomedicines · doi:10.3390/biomedicines8080277 · Cited by 253
Self-citation
Metadata
- Authors
- Sardu, C., Gambardella, J., Morelli, M. B., Wang, X., Marfella, R., & Santulli, G.
- Venue
- Journal of Clinical Medicine
- Publisher
- MDPI AG
- Published
- 2020-05-11
- Volume
- 9
- Issue
- 5
- Pages
- 1417
- ISSN
- 2077-0383 (ISSN-L)
- OpenAlex
- W3021377320
- Cited by
- 592
- References
- 237
- FWCI
- 15.99
- Type
- journal article
- Language
- en
- Open access
- gold
- Funders
- National Institutes of Health (R01-HL146691)
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