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Altered Gut Microbiota in Irritable Bowel Syndrome and Its Association with Food Components

Barandouzi, Zahra A., Lee, Joochul, Maas, Kendra, Starkweather, Angela R., Cong, Xiaomei S.·2021·Journal of Personalized Medicine
DOI 10.3390/jpm11010035
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Abstract

The interplay between diet and gut microbiota has gained interest as a potential contributor in pathophysiology of irritable bowel syndrome (IBS). The purpose of this study was to compare food components and gut microbiota patterns between IBS patients and healthy controls (HC) as well as to explore the associations of food components and microbiota profiles. A cross-sectional study was conducted with 80 young adults with IBS and 21 HC recruited. The food frequency questionnaire was used to measure food components. Fecal samples were collected and profiled by 16S rRNA Illumina sequencing. Food components were similar in both IBS and HC groups, except in caffeine consumption. Higher alpha diversity indices and altered gut microbiota were observed in IBS compared to the HC. A negative correlation existed between total observed species and caffeine intake in the HC, and a positive correlation between alpha diversity indices and dietary fiber in the IBS group. Higher alpha diversity and gut microbiota alteration were found in IBS people who consumed caffeine more than 400 mg/d. Moreover, high microbial diversity and alteration of gut microbiota composition in IBS people with high caffeine consumption may be a clue toward the effects of caffeine on the gut microbiome pattern, which warrants further study.

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Cited by

Metadata

Authors
Barandouzi, Z. A., Lee, J., Maas, K., Starkweather, A. R., & Cong, X. S.
Venue
Journal of Personalized Medicine
Publisher
MDPI AG
Published
2021-01-08
Volume
11
Issue
1
Pages
35
ISSN
2075-4426
DOI
10.3390/jpm11010035
Cited by
42
References
8
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)
Funders
  • National Institutes of Health (P20 NR016605-01)
  • American Nurses Foundation (10042)

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