Gut Microbiota in Patients With Irritable Bowel Syndrome—A Systematic Review
Abstract
Background & aims Irritable bowel syndrome (IBS) is common but difficult to treat. Altering the gut microbiota has been proposed as a strategy for treatment of IBS, but the association between the gut microbiome and IBS symptoms has not been well established. We performed a systematic review to explore evidence for this association. Methods We searched databases, including MEDLINE, EMBASE, Cochrane CDSR, and CENTRAL, through April 2, 2018 for case-control studies comparing the fecal or colon microbiomes of adult or pediatric patients with IBS with microbiomes of healthy individuals (controls). The primary outcome was differences in specific gut microbes between patients with IBS and controls. Results The search identified 2631 citations; 24 studies from 22 articles were included. Most studies evaluated adults presenting with various IBS subtypes. Family Enterobacteriaceae (phylum Proteobacteria), family Lactobacillaceae, and genus Bacteroides were increased in patients with IBS compared with controls, whereas uncultured Clostridiales I, genus Faecalibacterium (including Faecalibacterium prausnitzii), and genus Bifidobacterium were decreased in patients with IBS. The diversity of the microbiota was either decreased or not different in IBS patients compared with controls. More than 40% of included studies did not state whether cases and controls were comparable (did not describe sex and/or age characteristics). Conclusions In a systematic review, we identified specific bacteria…
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Small intestinal bacterial overgrowth has also been implicated, but its role is controversial due, in large part, to limitations of available diagnostic tests, such as glucose and lactulose breath tests and culture of jejunal aspirates.
“Small intestinal bacterial overgrowth (SIBO), has also been implicated, 44 but its role is controversial due, in large part, to limitations of available diagnostic tests, such as glucose and lactulose breath tests 45 and culture of jejunal aspirates. 46”
From Irritable bowel syndrome (2020) · cites this paper as [45]
Cites
Richness of human gut microbiome correlates with metabolic markers
Le Chatelier, E., Nielsen, T., Qin, J., Prifti, E., Hildebrand, F., Falony, G., Almeida, M., Arumugam, M., Batto, J.-M., Kennedy, S., et al. (2013) · Nature · doi:10.1038/nature12506 · Cited by 4,662 · see citing works
Ford, A. C., Harris, L. A., Lacy, B. E., Quigley, E. M. M., & Moayyedi, P. (2018) · Alimentary Pharmacology & Therapeutics · doi:10.1111/apt.15001 · Cited by 619 · see citing works
Self-citationtana, C., umesaki, Y., imaoka, A., handa, T., kanazawa, M., & fukudo, S. (2009) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2009.01427.x · Cited by 474 · see citing works
Carroll, I. M., Ringel‐Kulka, T., Siddle, J. P., & Ringel, Y. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01891.x · Cited by 425 · see citing works
Duboc, H., Rainteau, D., Rajca, S., Humbert, L., Farabos, D., Maubert, M., Grondin, V., Jouet, P., Bouhassira, D., Seksik, P., et al. (2012) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2012.01893.x · Cited by 256 · see citing works
Schwille-Kiuntke, J., Enck, P., Zendler, C., Krieg, M., Polster, A. V., Klosterhalfen, S., Autenrieth, I. B., Zipfel, S., & Frick, J.-S. (2011) · Neurogastroenterology & Motility · doi:10.1111/j.1365-2982.2011.01779.x · Cited by 110 · see citing works
Ringel-Kulka, T., Benson, A. K., Carroll, I. M., Kim, J., Legge, R. M., & Ringel, Y. (2016) · American Journal of Physiology-Gastrointestinal and Liver Physiology · doi:10.1152/ajpgi.00044.2015 · Cited by 53 · see citing works
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Ford, A. C., Sperber, A. D., Corsetti, M., & Camilleri, M. (2020) · The Lancet · doi:10.1016/s0140-6736(20)31548-8 · Cited by 818 · see citing works
Pittayanon, R., Lau, J. T., Leontiadis, G. I., Tse, F., Yuan, Y., Surette, M., & Moayyedi, P. (2020) · Gastroenterology · doi:10.1053/j.gastro.2019.11.294 · Cited by 623 · see citing works
Self-citationMcGuinness, A. J., Davis, J. A., Dawson, S. L., Loughman, A., Collier, F., O’Hely, M., Simpson, C. A., Green, J., Marx, W., Hair, C., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-022-01456-3 · Cited by 502 · see citing works
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome
Mars, R. A. T., Yang, Y., Ward, T., Houtti, M., Priya, S., Lekatz, H. R., Tang, X., Sun, Z., Kalari, K. R., Korem, T., et al. (2020) · Cell · doi:10.1016/j.cell.2020.08.007 · Cited by 456 · see citing works
RETRACTED ARTICLE: Role of the gut microbiome in chronic diseases: a narrative review
Vijay, A., & Valdes, A. M. (2022) · European Journal of Clinical Nutrition · doi:10.1038/s41430-021-00991-6 · Cited by 361 · see citing works
RetractedPaediatric functional abdominal pain disorders
Thapar, N., Benninga, M. A., Crowell, M. D., Di Lorenzo, C., Mack, I., Nurko, S., Saps, M., Shulman, R. J., Szajewska, H., van Tilburg, M. A. L., et al. (2020) · Nature Reviews Disease Primers · doi:10.1038/s41572-020-00222-5 · Cited by 221 · see citing works
Labanski, A., Langhorst, J., Engler, H., & Elsenbruch, S. (2020) · Psychoneuroendocrinology · doi:10.1016/j.psyneuen.2019.104501 · Cited by 200 · see citing works
Ge, L., Liu, S., Li, S., Yang, J., Hu, G., Xu, C., & Song, W. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.1016578 · Cited by 187 · see citing works
The Gut Microbial Bile Acid Modulation and Its Relevance to Digestive Health and Diseases
Fogelson, K. A., Dorrestein, P. C., Zarrinpar, A., & Knight, R. (2023) · Gastroenterology · doi:10.1053/j.gastro.2023.02.022 · Cited by 177 · see citing works
Sex- and Gender-Related Differences in Common Functional Gastroenterologic Disorders
Narayanan, S. P., Anderson, B., & Bharucha, A. E. (2021) · Mayo Clinic Proceedings · doi:10.1016/j.mayocp.2020.10.004 · Cited by 131 · see citing works
No distinct microbiome signature of irritable bowel syndrome found in a Swedish random population
Hugerth, L. W., Andreasson, A., Talley, N. J., Forsberg, A. M., Kjellström, L., Schmidt, P. T., Agreus, L., & Engstrand, L. (2020) · Gut · doi:10.1136/gutjnl-2019-318717 · Cited by 102 · see citing works
Johnsen, P. H., Hilpüsch, F., Valle, P. C., & Goll, R. (2020) · EBioMedicine · doi:10.1016/j.ebiom.2019.11.023 · Cited by 64 · see citing works
“Finally, only 14 of 664 genera conform to a core microbiota of the gut, so the donor microbiota was probably very different between studies [28].”
BackgroundEvidence-based and mechanistic insights into exclusion diets for IBS
Moayyedi, P., Simrén, M., & Bercik, P. (2020) · Nature Reviews Gastroenterology & Hepatology · doi:10.1038/s41575-020-0270-3 · Cited by 64 · see citing works
Self-citation
- Authors
- Pittayanon, R., Lau, J. T., Yuan, Y., Leontiadis, G. I., Tse, F., Surette, M., & Moayyedi, P.
- Affiliations
- Thai Red Cross Society (TH)
- McMaster University (CA)
- Corresponding author
- Moayyedi, Paul
- ORCID
- Venue
- Gastroenterology
- Publisher
- Elsevier BV
- Published
- 2019-07
- Volume
- 157
- Issue
- 1
- Pages
- 97-108
- ISSN
- 0016-5085 (ISSN-L)
- OpenAlex
- W2934588014
- Cited by
- 719
- References
- 7
- Citations by year
- 2026: 71 · 2025: 94 · 2024: 121 · 2023: 114 · 2022: 129 · 2021: 104 · 2020: 67 · 2019: 18
- FWCI
- 7.20
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Canadian Institutes of Health Research (RN279389–358033)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
- Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
- Health Sciences › Medicine › Epidemiology › Microscopic Colitis
- Keywords
- irritable bowel syndrome, gut microbiota, microbiome, IBS subtypes, Enterobacteriaceae, Lactobacillaceae, Bacteroides, Faecalibacterium prausnitzii, Bifidobacterium, Clostridiales, microbial diversity, fecal microbiota, colon microbiome, microbiota-based therapy
- MeSH terms
- Eubacteriales, Clostridiales, Gastrointestinal Microbiome, Faecalibacterium, Bacteroides, Bifidobacterium, Enterobacteriaceae, Humans, Lactobacillaceae, Irritable Bowel Syndrome
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