Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors

Salam, Uzma; Ullah, Shakir; Tang, Zhong-Hua; Elateeq, Ahmed A.; Khan, Yaseen; Khan, Jafar; Khan, Asif; Ali, Sajid

doi:10.3390/life13030706

Cited by 505Plant Stress Responses and TolerancePlant biochemistry and biosynthesisPlant-Microbe Interactions and Immunity

Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors

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Salam, Uzma, Ullah, Shakir, Tang, Zhong-Hua, Elateeq, Ahmed A., Khan, Yaseen, Khan, Jafar, Khan, Asif, Ali, Sajid·2023·Life

DOI 10.3390/life13030706PMC PMC10051737

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Abstract

Several environmental stresses, including biotic and abiotic factors, adversely affect the growth and development of crops, thereby lowering their yield. However, abiotic factors, e.g., drought, salinity, cold, heat, ultraviolet radiations (UVr), reactive oxygen species (ROS), trace metals (TM), and soil pH, are extremely destructive and decrease crop yield worldwide. It is expected that more than 50% of crop production losses are due to abiotic stresses. Moreover, these factors are responsible for physiological and biochemical changes in plants. The response of different plant species to such stresses is a complex phenomenon with individual features for several species. In addition, it has been shown that abiotic factors stimulate multi-gene responses by making modifications in the accumulation of the primary and secondary metabolites. Metabolomics is a promising way to interpret biotic and abiotic stress tolerance in plants. The study of metabolic profiling revealed different types of metabolites, e.g., amino acids, carbohydrates, phenols, polyamines, terpenes, etc, which are accumulated in plants. Among all, primary metabolites, such as amino acids, carbohydrates, lipids polyamines, and glycine betaine, are considered the major contributing factors that work as osmolytes and osmoprotectants for plants from various environmental stress factors. In contrast, plant-derived secondary metabolites, e.g., phenolics, terpenoids, and nitrogen-containing compounds (alkaloids), have no direct role in the growth and development of plants. Nevertheless, such metabolites could play a significant role as a defense by protecting plants from biotic factors such as herbivores, insects, and pathogens. In addition, they can enhance the resistance against abiotic factors. Therefore, metabolomics practices are becoming essential and influential in plants by identifying different phytochemicals that are part of the acclimation responses to various stimuli. Hence, an accurate metabolome analysis is important to understand the basics of stress physiology and biochemistry. This review provides insight into the current information related to the impact of biotic and abiotic factors on variations of various sets of metabolite levels and explores how primary and secondary metabolites help plants in response to these stresses.

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While the consistency of the leaves was standardized by selecting those with a similar structure and without damage, tree age and growth stage may still influence the phytochemical profile and antioxidant activity.
“While the consistency of the leaves was standardized by selecting those with a similar structure and without damage, tree age and growth stage may still influence the phytochemical profile and antioxidant activity.”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [63]
Section 4.2 (page unavailable) says the concentration of secondary metabolites is controlled partly by the growing period, supporting the possibility that growth stage affects phytochemical profiles. It also describes antioxidant roles for those metabolites, but does not say that tree age or growth stage changes antioxidant activity. The leaf-selection procedure is the citing authors’ own description, not a finding attributed to this review. (LLM, conf=0.82)
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Older trees might produce different concentrations of secondary metabolites compared to younger ones, potentially affecting the antioxidant capacity of the extracts and infusions.
“Older trees might produce different concentrations of secondary metabolites compared to younger ones, potentially affecting the antioxidant capacity of the extracts and infusions [62,63,64].”
From Comparative Analysis of Infusions and Ethanolic Extracts of Annona muricata Leaves from Colima, Mexico: Phytochemical Profile and Antioxidant Activity (2024) · cites this paper as [63]
Section 4.2 says secondary-metabolite concentrations are influenced by the growing period and describes antioxidant roles for these compounds; it also links flavonoid content to antioxidant activity. It does not specifically compare older and younger trees or assess the antioxidant capacity of their extracts or infusions. No page numbers are available in our copy. (LLM, conf=0.82)
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Authors: Salam, U., Ullah, S., Tang, Z.-H., Elateeq, A. A., Khan, Y., Khan, J., Khan, A., & Ali, S.
Affiliations: Northeast Forestry University (CN)
Key Laboratory of Plant Ecology, Northeast Forestry Universit y, Harbin 150040, China
Al-Azhar University (EG)
Northwest A&F University (CN)
Universidade de São Paulo (BR)
Yeungnam University (KR)
Corresponding author: Ali, Sajid
ORCID: Ullah, Shakir
Tang, Zhong-Hua
Elateeq, Ahmed A.
Khan, Yaseen
Khan, Asif
Ali, Sajid
Venue: Life
Publisher: MDPI AG
Published: 2023-03-06
Volume: 13
Issue: 3
Pages: 706
ISSN: 2075-1729 (ISSN-L)
DOI: 10.3390/life13030706
PMC: PMC10051737
OpenAlex: W4323313289
Cited by: 480
References: 210
Citations by year: 2026: 165 · 2025: 192 · 2024: 104 · 2023: 19
FWCI: 11.50
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Life (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: The key Research and Development project of Heilongjiang Province, China (JD22A008)
Topics: Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant Stress Responses and Tolerance
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Plant biochemistry and biosynthesis
Life Sciences › Agricultural and Biological Sciences › Plant Science › Plant-Microbe Interactions and Immunity
Keywords: plant metabolomics, primary metabolites, secondary metabolites, abiotic stress, biotic stress, drought stress, salt stress, cold stress, heat stress, ultraviolet radiation, reactive oxygen species, trace metals, soil pH, osmolytes, betaine, polyamines, phenolic compounds, terpenoids, alkaloids, plant stress tolerance, crop yield loss

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Plant Metabolomics: An Overview of the Role of Primary and Secondary Metabolites against Different Environmental Stress Factors

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