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Herbal- and Dietary-Supplement-Induced Liver Injury: A Review of the Recent Literature

Patel-Rodrigues, Palak A., Cundra, Lindsey, Alhaqqan, Dalal, Gildea, Daniel T., Woo, Stephanie M., Lewis, James H.·2024·Livers
DOI 10.3390/livers4010008
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Abstract

Herbal-induced liver injury (HILI) continues to increase in prevalence each year due to the ongoing popularity of herbal supplements and complementary and alternative medicines. A detailed literature review of case reports and clinical studies published from March 2021 to March 2023 was performed. We discuss the epidemiology and diagnosis of HILI as well as the current and proposed laws and regulations. The 2021 ACG guidelines and 2022 AASLD practice guidelines for the diagnosis and management of drug and herbal-induced liver injury are discussed. We describe updates to previously reported etiologies of HILI such as ayurveda, ashwagandha, turmeric, kratom, green tea extract, and garcinia cambogia. Newly described supplements resulting in HILI, such as tinospora cordifolia, horse chestnut, alkaline water, and more, are described. We discuss newly and previously identified hepatoprotective herbal supplements as they have been reported in the study of animal models and human liver cells. This review suggests the need for ongoing research on the causes and mechanisms of HILI to ensure its proper diagnosis, prevention, and treatment in the future. The goal of this review is to provide novice and expert readers with knowledge regarding the possible etiologies of HILI and a general overview.

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Metadata

Authors
Patel-Rodrigues, P. A., Cundra, L., Alhaqqan, D., Gildea, D. T., Woo, S. M., & Lewis, J. H.
Venue
Livers
Publisher
MDPI AG
Published
2024-02-13
Volume
4
Issue
1
Pages
94-118
ISSN
2673-4389
DOI
10.3390/livers4010008
Cited by
29
References
4
Language
en
Licence
creativecommons.org/licenses/by/4.0/ (vor)

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