Sustained administration of hormones exploiting nanoconfined diffusion through nanochannel membranes
Open accessAbstract
Implantable devices may provide a superior means for hormone delivery through maintaining serum levels within target therapeutic windows. Zero-order administration has been shown to reach an equilibrium with metabolic clearance, resulting in a constant serum concentration and bioavailability of released hormones. By exploiting surface-to-molecule interaction within nanochannel membranes, it is possible to achieve a long-term, constant diffusive release of agents from implantable reservoirs. In this study, we sought to demonstrate the controlled release of model hormones from a novel nanochannel system. We investigated the delivery of hormones through our nanochannel membrane over a period of 40 days. Levothyroxine, osteocalcin and testosterone were selected as representative hormones based on their different molecular properties and structures. The release mechanisms and transport behaviors of these hormones within 3, 5 and 40 nm channels were characterized. Results further supported the suitability of the nanochannels for sustained administration from implantable platforms.
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In vivo experiments revealed a 0-order release profile lasting for more than 15 days for a subcutaneous implantable device.
“In vivo experiments revealed a 0-order release profile lasting for more than 15 days.”
From Levothyroxine: conventional and novel drug delivery formulations. (2023) · cites this paper as [270]
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- Authors
- Geninatti, T., Hood, R., Bruno, G., Jain, P., Nicolov, E., Ziemys, A., & Grattoni, A.
- Affiliations
- Houston Methodist (US)
- Nanomedicine Department, Houston Methodist Research Institute, Houston, TX 77030, USA
- Corresponding author
- Grattoni, Alessandro
- Venue
- Materials
- Publisher
- MDPI AG
- Published
- 2015-08-13
- Volume
- 8
- Issue
- 8
- Pages
- 5276-5288
- ISSN
- 1996-1944 (ISSN-L)
- PMC
- PMC4898476
- OpenAlex
- W2096897782
- Cited by
- 13
- References
- 50
- Citations by year
- 2026: 1 · 2024: 1 · 2023: 3 · 2022: 2 · 2018: 3 · 2017: 2 · 2015: 1
- FWCI
- 0.99
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Materials (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- PORTO@Iris (submittedVersion, cc-by)
- PORTO Publications Open Repository TOrino (Politecnico di Torino) (submittedVersion)
- Funders
- NIH (NIGMS R21 GM111544)
- CASIS (GA-14-145)
- Topics
- Physical Sciences › Engineering › Biomedical Engineering › Nanopore and Nanochannel Transport Studies
- Physical Sciences › Materials Science › Biomaterials › Electrospun Nanofibers in Biomedical Applications
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Keywords
- nanochannel membranes, hormone delivery, sustained drug release, zero-order release, levothyroxine, osteocalcin, testosterone, hormone transport, controlled release
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