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Cited by 28biodegradable polymer synthesis and propertiesHydrogels: synthesis, properties, applicationsPolymer crystallization and properties

The influence of the molecular weight of poly (ethylene oxide) on the hydrolytic degradation and physical properties of polycaprolactone binary blends

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Dalton, Maurice, Ebrahimi, Farnoosh, Xu, Han, Gong, Ke, Fehrenbach, Gustavo, Fuenmayor, Evert, Murphy, Emma J., Major, Ian·2023·Macromol
DOI 10.3390/macromol3030026
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Abstract

The use of biodegradable polymers in tissue engineering has been widely researched due to their ability to degrade and release their components in a controlled manner, allowing for the potential regeneration of tissues. Melt blending is a common method for controlling the degradation rate of these polymers, which involves combining these materials in a molten state to create a homogenous mixture with tailored properties. In this study, polycaprolactone (PCL) was melt blended with hydrophilic poly (ethylene oxide) (PEO) of different molecular weights to assess its effect on PCL material performance. Hydrolytic degradation, thermal and viscoelastic properties, and surface hydrophilicity were performed to contrast the properties of the blends. DSC, DMA, and FTIR were performed on selected degraded PCL/PEO specimens following mass loss studies. The results showed that adding PEO to PCL reduced its melt viscosity-torque and melt temperature while increasing its hydrophilicity, optimizing PCL/PEO blend for soft tissue engineering applications and could contribute to the development of more effective and biocompatible materials for soft tissue regeneration.

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  • PCL can be tailored by modifying molecular weight or incorporating bioactive coatings to optimize barrier properties while ensuring biocompatibility.

    “By modifying molecular weight or incorporating bioactive coatings, PCL films can be tailored to optimize their barrier properties while ensuring biocompatibility [195].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [195]

    The Introduction and Conclusions (pages not provided) describe tailoring PCL/PEO blends using PEO of different molecular weights and identify biocompatibility as relevant to tissue-engineering applications. They do not establish that changing PCL's molecular weight or adding bioactive coatings optimizes the barrier properties of PCL films. Coatings appear in the cited paper's references, not as a finding of this study. (LLM, conf=0.85)

    Experimental — accuracy not yet measured

  • PCL's slow degradation rate ensures that the barrier remains intact for an extended period, allowing tissues to heal separately before resorption occurs.

    “One of PCL’s primary advantages in adhesion prevention is its slow degradation rate, which ensures that the barrier remains intact for an extended period, allowing tissues to heal separately before resorption occurs [195].”

    From Biomaterials in Postoperative Adhesion Barriers and Uterine Tissue Engineering (2025) · cites this paper as [195]

    The Introduction states that PCL degrades slowly and has been used for hard-tissue replacement where healing takes an extended period. It does not address adhesion-prevention barriers or establish that a barrier remains intact while separate tissues heal before resorption. (LLM, conf=0.88)

    Experimental — accuracy not yet measured

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Cited by

Sorted by citations

Authors
Dalton, M., Ebrahimi, F., Xu, H., Gong, K., Fehrenbach, G., Fuenmayor, E., Murphy, E. J., & Major, I.
Affiliations
Technological University of the Shannon: Midlands Midwest (IE)
Corresponding author
Major, Ian
ORCID
Venue
Macromol
Publisher
MDPI AG
Published
2023-07-03
Volume
3
Issue
3
Pages
431-450
ISSN
2673-6209 (ISSN-L)
DOI
10.3390/macromol3030026
OpenAlex
W4382983144
Cited by
28
References
3
Citations by year
2026: 8 · 2025: 7 · 2024: 10 · 2023: 3
FWCI
1.74
Type
journal article
Language
en
Open access
Licence
Locations
  • Macromol—A Journal of Macromolecular Research (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Physical Sciences › Materials Science › Biomaterials › biodegradable polymer synthesis and properties
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Medicine › Hydrogels: synthesis, properties, applications
  • Physical Sciences › Materials Science › Polymers and Plastics › Polymer crystallization and properties
Keywords
polycaprolactone, poly(ethylene oxide), polymer blends, molecular weight effects, hydrolytic degradation, melt blending, biodegradable polymers, tissue engineering scaffolds, soft tissue regeneration, hydrophilicity, thermal properties, viscoelasticity, melt viscosity

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