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Lipid Production from Nannochloropsis
Open accessAbstract
Microalgae are sunlight-driven green cell factories for the production of potential bioactive products and biofuels. Nannochloropsis represents a genus of marine microalgae with high photosynthetic efficiency and can convert carbon dioxide to storage lipids mainly in the form of triacylglycerols and to the ω-3 long-chain polyunsaturated fatty acid eicosapentaenoic acid (EPA). Recently, Nannochloropsis has received ever-increasing interests of both research and public communities. This review aims to provide an overview of biology and biotechnological potential of Nannochloropsis, with the emphasis on lipid production. The path forward for the further exploration of Nannochloropsis for lipid production with respect to both challenges and opportunities is also discussed.
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![Figure 2 Schematic diagrams of the replication cycle of N. oculata. The order of the nuclear (N) and plastid (P) division is not strictly fixed. Nuclear division precedes the plastid division (upper); or vice versa (lower) [18].](/paper-figures/772529fdb432462b8739b9f752e88eb1/lipid-production-from-nannochloropsis-figure-2.jpg)
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“Genetic engineering plays a potentially pivotal role in advancing algal biofuels, aiming to tailor microalgal strains for an enhanced production of specific fuel precursors or even a direct synthesis of molecules like biodiesel, butanol, gasoline components, methane, ethanol, or jet fuel [165].”
From Biofuels, E-Fuels, and Waste-Derived Fuels: Advances, Challenges, and Future Directions (2025) · cites this paper as [165]
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“While specific quantitative comparisons of CO 2 -to-lipid conversion efficiencies between genetically modified strains (e.g., Nannochloropsis gaditana) and their wild-type counterparts require further consolidated data, research confirms the high lipid accumulation potential of species like N. gaditana (e.g., reaching 0.32 g/L lipid yield under specific enriched CO 2 lab conditions) and the focus”
From Biofuels, E-Fuels, and Waste-Derived Fuels: Advances, Challenges, and Future Directions (2025) · cites this paper as [165]
Experimental — accuracy not yet measuredThe source backs part of the claim, not all of it — or backs it for a different population, condition or comparison.
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“Simultaneously with an increase in lipid content, nitrogen starvation can decrease PUFA production, which is valuable for biodiesel production [1, 17–19].”
From Nitrogen and phosphorus stress as a tool to induce lipid production in microalgae (2023) · cites this paper as [17]
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Chisti, Y. (2007) · Biotechnology Advances · doi:10.1016/j.biotechadv.2007.02.001 · Cited by 9,524
Microalgal triacylglycerols as feedstocks for biofuel production: perspectives and advances
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An outlook on microalgal biofuels
Wijffels, R. H., & Barbosa, M. J. (2010) · Science · doi:10.1126/science.1189003 · Cited by 1,886
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‘Morphology, composition, production, processing and applications of Chlorella vulgaris: a review’.
Safi, C., Zebib, B., Merah, O., Pontalier, P.-Y., & Vaca-Garcia, C. (2014) · Renewable and Sustainable Energy Reviews · doi:10.1016/j.rser.2014.04.007 · Cited by 1,127
Fatty acid biosynthesis in microorganisms being used for Single Cell Oil production
Ratledge, C. (2004) · Biochimie · doi:10.1016/j.biochi.2004.09.017 · Cited by 1,125
Biodiesel production by microalgal biotechnology
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Self-citationSensing and Responding to Excess Light
Li, Z., Wakao, S., Fischer, B. B., & Niyogi, K. (2008) · Annual Review of Plant Biology · doi:10.1146/annurev.arplant.58.032806.103844 · Cited by 1,014
Enzymes of triacylglycerol synthesis and their regulation
Coleman, R. (2003) · Progress in Lipid Research · doi:10.1016/s0163-7827(03)00051-1 · Cited by 961
Cited by
Sorted by citations
Ajjawi, I., Verruto, J., Aqui, M., Soriaga, L. B., Coppersmith, J. L., Kwok, K., Peach, L., Orchard, E. D., Kalb, R., Xu, W., et al. (2017) · Nature Biotechnology · doi:10.1038/nbt.3865 · Cited by 481
Saini, R. K., Prasad, P., Sreedhar, R. V., Akhilender Naidu, K., Shang, X., & Keum, Y.-S. (2021) · Antioxidants · doi:10.3390/antiox10101627 · Cited by 337
Amorim, M. L., Soares, J., Coimbra, J. S. D. R., Leite, M. D. O., Albino, L. F. T., & Martins, M. A. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1768046 · Cited by 325
The role of microalgae in the bioeconomy
Acién, F. G., dos Reis, A. J. D., Wijffels, R. H., Barbosa, M. J., Verdelho, V., & Llamas, B. (2020) · New Biotechnology · doi:10.1016/j.nbt.2020.11.011 · Cited by 294
Is exploitation of microalgae economically and energetically sustainable?
Barsanti, L. A., & Gualtieri, P. (2018) · Algal Research · doi:10.1016/j.algal.2018.02.001 · Cited by 270
Metadata
- Authors
- Ma, X.-N., Chen, T.-P., Yang, B., Liu, J., & Chen, F.
- Affiliations
- Institute for Food and Bioresource Engineering, College of Engineering, Peking University, Beijing 100871, China
- Peking University (CN)
- Corresponding author
- Liu, Jin
- Chen, Feng
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2016-03-25
- Volume
- 14
- Issue
- 4
- Pages
- 61
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC4849066
- OpenAlex
- W2309000102
- Cited by
- 394
- References
- 104
- Citations by year
- 2026: 48 · 2025: 52 · 2024: 37 · 2023: 44 · 2022: 33 · 2021: 43 · 2020: 46 · 2019: 38 · 2018: 31 · 2017: 17 · 2016: 3
- FWCI
- 1.09
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Funders
- National Natural Science Foundation of China (31471717, 31571807)
- Peking University
- Ocean Public Welfare Scientific Research Project (201505032)
- Topics
- Physical Sciences › Energy › Renewable Energy, Sustainability and the Environment › Algal biology and biofuel production
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biochemistry › Lipid metabolism and biosynthesis
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Microbial Metabolic Engineering and Bioproduction
- Keywords
- Nannochloropsis, microalgae, lipid production, triglycerides, eicosapentaenoic acid, omega-3 fatty acids, biofuels, photosynthetic efficiency, CO2 conversion, microalgal biotechnology
- MeSH terms
- Animals, Biotechnology, Humans, Lipids, Triglycerides, Eicosapentaenoic Acid, Fatty Acids, Omega-3, Stramenopiles, Microalgae
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