Current Status and Future Prospects of Marine Natural Products (MNPs) as Antimicrobials
Open accessAbstract
The marine environment is a rich source of chemically diverse, biologically active natural products, and serves as an invaluable resource in the ongoing search for novel antimicrobial compounds. Recent advances in extraction and isolation techniques, and in state-of-the-art technologies involved in organic synthesis and chemical structure elucidation, have accelerated the numbers of antimicrobial molecules originating from the ocean moving into clinical trials. The chemical diversity associated with these marine-derived molecules is immense, varying from simple linear peptides and fatty acids to complex alkaloids, terpenes and polyketides, etc. Such an array of structurally distinct molecules performs functionally diverse biological activities against many pathogenic bacteria and fungi, making marine-derived natural products valuable commodities, particularly in the current age of antimicrobial resistance. In this review, we have highlighted several marine-derived natural products (and their synthetic derivatives), which have gained recognition as effective antimicrobial agents over the past five years (2012–2017). These natural products have been categorized based on their chemical structures and the structure-activity mediated relationships of some of these bioactive molecules have been discussed. Finally, we have provided an insight into how genome mining efforts are likely to expedite the discovery of novel antimicrobial compounds.
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Thirteen natural products isolated from marine organisms are being tested in different phases of clinical trials.
“Consequently, a large number of natural products are in preclinical investigations, and 13 natural products isolated from marine organisms are being tested in different phases of clinical trials, highlighting the potential of marine natural compounds [25].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [25]
Section 2 reports compounds in the preclinical pipeline, supporting that part of the sentence. But Section 15 (Concluding Remarks and Future Prospects) says 12 MNPs or derivatives are in different phases of clinical trials, not 13 natural products isolated from marine organisms. (LLM, conf=0.89)
Experimental — accuracy not yet measuredA large number of natural products are in preclinical investigations.
“Consequently, a large number of natural products are in preclinical investigations, and 13 natural products isolated from marine organisms are being tested in different phases of clinical trials, highlighting the potential of marine natural compounds [25].”
From Marine Natural Products: A Source of Novel Anticancer Drugs (2019) · cites this paper as [25]
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“Consequently, a large number of natural products are in preclinical investigations, and 13 natural products isolated from marine organisms are being tested in different phases of clinical trials, highlighting the potential of marine natural compounds [25].”
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Marine Algal Polyphenols as Skin Protective Agents: Current Status and Future Prospectives
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- Authors
- Choudhary, A., Naughton, L., Montánchez, I., Dobson, A., & Rai, D.
- Affiliations
- Teagasc - The Irish Agriculture and Food Development Authority (IE)
- University College Cork (IE)
- University of the Basque Country (ES)
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2017-08-28
- Volume
- 15
- Issue
- 9
- Pages
- 272
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC5618411
- OpenAlex
- W2749503111
- Cited by
- 138
- References
- 145
- Citations by year
- 2026: 6 · 2025: 10 · 2024: 18 · 2023: 18 · 2022: 13 · 2021: 23 · 2020: 21 · 2019: 18 · 2018: 10 · 2017: 1
- FWCI
- 1.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- Arrow@dit (Dublin Institute of Technology) (acceptedVersion)
- Cork Open Research Archive (University College Cork, Ireland) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- T-Stór (Teagasc) (submittedVersion, cc-by-nc-sa)
- Funders
- Department of Agriculture, Food and the Marine, Ireland (11/F/009)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
- Health Sciences › Medicine › Pharmacology › Microbial Natural Products and Biosynthesis
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Keywords
- marine natural products, antimicrobial agents, antimicrobial resistance, marine bacteria, marine fungi, structure-activity relationship, marine alkaloids, terpenes, polyketides, marine peptides, marine fatty acids, synthetic derivatives, genome mining, natural product isolation
- MeSH terms
- Alkaloids, Anti-Infective Agents, Biological Products, Humans, Marine Biology, Terpenes, Molecular Structure, Polyketides
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