The DOI matches its Crossref record; 32 of the 32 references it cites were found in a registry or an index.
Inhibition of Adipogenesis by Diphlorethohydroxycarmalol (DPHC) through AMPK Activation in Adipocytes
Open accessAbstract
The purpose of this study was to investigate the antiobesity effect and the mechanism of action of diphlorethohydroxycarmalol (DPHC) isolated from Ishige okamurae in 3T3-L1 cells. The antiobesity effects were examined by evaluating intracellular fat accumulation in Oil Red O-stained adipocytes. Based on the results, DPHC dose-dependently inhibited the lipid accumulation in 3T3-L1 adipocytes. DPHC significantly inhibited adipocyte-specific proteins such as SREBP-1c, PPARγ, C/EBP α, and adiponectin, as well as adipogenic enzymes, including perilipin, FAS, FABP4, and leptin in adipocytes. These results indicated that DPHC primarily acts by regulating adipogenic-specific proteins through inhibiting fat accumulation and fatty acid synthesis in adipocytes. DPHC treatment significantly increased both AMPK and ACC phosphorylation in adipocytes. These results indicate that DPHC inhibits the fat accumulation by activating AMPK and ACC in 3T3-L1 cells. Taken together, these results suggest that DPHC can be used as a potential therapeutic agent against obesity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
Adipocytes play a vital role in the regulation of energy intake, energy expenditure, and both lipid and carbohydrate metabolism; lowering lipogenesis, enhancing lipolysis, and decreasing pre-adipocyte differentiation are strategies against obesity.
“Adipocytes play a vital role in the regulation of energy intake, energy expenditure, and both lipid and carbohydrate metabolism; thus, they lower lipogenesis, enhance lipolysis, and decrease pre-adipocyte differentiation, all of which are strategies against obesity [14,15,19].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [15]
Obesity is influenced by numerous factors, such as energy balance, biological factors, and hormones/cytokines/other factors.
“Evidences showed obesity is influenced by numerous factors, such as the energy balance, biological factors, and hormones/cytokines/other factors [15,16].”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [15]
PPARγ, C/EBPα, and SREBP-1c are important regulators of adipogenesis.
“In mammalian cells, the peroxisome proliferator-activated receptor γ (PPARγ), CCAAT/enhancer binding protein α (C/EBPα), and sterol regulatory element-binding protein 1c (SREBP-1c) [15] are known to act as important regulators of adipogenesis.”
From Separation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose (2019) · cites this paper as [15]
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Adipocytes as regulators of energy balance and glucose homeostasis
Rosen, E. D., & Spiegelman, B. M. (2006) · Nature · doi:10.1038/nature05483 · Cited by 2,170 · cited 2×
“Adipocytes play a vital role in the regulati n of energy intake, energy ex e it re, a lipid and carbohydrate metabolism [21].”
BackgroundObesity Stigma: Important Considerations for Public Health
Puhl, R. M., & Heuer, C. A. (2010) · American Journal of Public Health · doi:10.2105/ajph.2009.159491 · Cited by 1,949
State of the art paper Biochemistry of adipose tissue: an endocrine organ
Coelho, M., Oliveira, T., & Fernandes, R. (2013) · Archives of Medical Science · doi:10.5114/aoms.2013.33181 · Cited by 1,201
Chronic Inflammation in Obesity and the Metabolic Syndrome
Monteiro, R., & Azevedo, I. (2010) · Mediators of Inflammation · doi:10.1155/2010/289645 · Cited by 1,186 · cited 1×
“Obesity is a metabolic disease characterized by an excessive accumulation of body fat and further associated with complications such as type 2 diabetes, hypertension, hyperlipidemia, and increased risk of cancer and cardiovascular disease [3,4].”
BackgroundEconomic Burden of Obesity: A Systematic Literature Review
Tremmel, M., Gerdtham, U., Nilsson, P., & Saha, S. (2017) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph14040435 · Cited by 1,162
AMPK activators: mechanisms of action and physiological activities
Kim, J., Yang, G., Kim, Y., Kim, J., & Ha, J. (2016) · Experimental & Molecular Medicine · doi:10.1038/emm.2016.16 · Cited by 817
Possible anti-obesity therapeutics from nature--a review
Yun, J. W. (2010) · Phytochemistry · doi:10.1016/j.phytochem.2010.07.011 · Cited by 619
Obesity: Prevalence, Theories, Medical Consequences, Management, and Research Directions
Wilborn, C., Beckham, J., Campbell, B. I., Harvey, T. M., Galbreath, M., Bounty, P. L., Nassar, E., Wismann, J. A., & Kreider, R. B. (2005) · Journal of the International Society of Sports Nutrition · doi:10.1186/1550-2783-2-2-4 · Cited by 247
Mohamed, G. A., Ibrahim, S. R. M., Elkhayat, E. S., & Dine, R. S. E. (2014) · Bulletin of Faculty of Pharmacy Cairo University · doi:10.1016/j.bfopcu.2014.05.001 · Cited by 241
Natural Dietary and Herbal Products in Anti-Obesity Treatment
Sun, N.-N., Wu, T.-Y., & Chau, C. (2016) · Molecules · doi:10.3390/molecules21101351 · Cited by 230
Adipokines as novel modulators of lipid metabolism
Lago, F., Gómez, R., Gómez-Reino, J. J., Diéguez, C., & Gualillo, O. (2009) · Trends in Biochemical Sciences · doi:10.1016/j.tibs.2009.06.008 · Cited by 215
C/EBP transcription factors regulate SREBP1c gene expression during adipogenesis
Payne, V. A., Au, W.-S., Lowe, C. E., Rahman, S. M., Friedman, J. E., O’Rahilly, S., & Rochford, J. J. (2009) · Biochemical Journal · doi:10.1042/bj20091112 · Cited by 214
Role of obesity-associated dysfunctional adipose tissue in cancer: A molecular nutrition approach
Prieto-Hontoria, P. L., Pérez‐Matute, P., Fernández‐Galilea, M., Bustos, M., Martínez, J. A., & Moreno-Aliaga, M. J. (2010) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2010.11.004 · Cited by 167
Zou, Y., Qian, Z., Li, Y., Kim, M., Lee, S., & Kim, S. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf801133h · Cited by 162
Self-citationGruzman, A., Babai-Shani, G., & Sasson, S. (2009) · The Review of Diabetic Studies · doi:10.1900/rds.2009.6.13 · Cited by 128
Chang, C., Lin, K.-Y., Peng, K., Day, Y., & Hung, L. (2015) · Endocrine Journal · doi:10.1507/endocrj.ej15-0545 · Cited by 105
Kang, M., Kang, N., Ko, S., Kim, Y., & Jeon, Y. (2016) · Food and Chemical Toxicology · doi:10.1016/j.fct.2016.01.023 · Cited by 104
Self-citationAdenosine Monophosphate (AMP)-Activated Protein Kinase: A New Target for Nutraceutical Compounds
Marín‐Aguilar, F., Pavillard, L. E., Giampieri, F., Bullón, P., & Cordero, M. D. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18020288 · Cited by 103
Chan, C. Y., Wei, L., Castro‐Muñozledo, F., & Koo, W. L. (2011) · Life Sciences · doi:10.1016/j.lfs.2011.09.006 · Cited by 102
Rizzatti, V., Boschi, F., Pedrotti, M., Zoico, E., Sbarbati, A., & Zamboni, M. M. (2013) · European Journal of Histochemistry · doi:10.4081/ejh.2013.e24 · Cited by 101
Anti-adipogenic effect of dioxinodehydroeckol via AMPK activation in 3T3-L1 adipocytes
Kim, S., & Kong, C. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.04.003 · Cited by 96
Choi, H., Jeon, H., Lee, O., & Lee, B. (2015) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.201500021 · Cited by 67
Tung, Y., Hsieh, P., Pan, M., & Ho, C. (2016) · Journal of Food and Drug Analysis · doi:10.1016/j.jfda.2016.10.018 · Cited by 64
Kang, M., Ding, Y., Kim, E.-A. L., Choi, Y. K., Araujo, T. D., Heo, S., & Lee, S. (2017) · Marine Drugs · doi:10.3390/md15040119 · Cited by 60
Self-citationKang, M., Lee, S., Lee, W., Kang, N., Kim, E.-A. L., Kim, S. C., Lee, D. H., Kim, D., & Jeon, Y. (2014) · Journal of Functional Foods · doi:10.1016/j.jff.2014.09.007 · Cited by 42
Self-citationLee, M.-S., Cho, S.-M., Lee, M., Lee, E., Kim, S., & Lee, H. (2016) · BMC Complementary and Alternative Medicine · doi:10.1186/s12906-016-1031-2 · Cited by 35
Park, M. H., Jeon, Y., Kim, H., & Han, J.-S. (2012) · Phytotherapy Research · doi:10.1002/ptr.4797 · Cited by 28
Self-citationHan, M. H., Jeong, J.-S., Jeong, J.-W., Choi, S. H., Kim, S. O., Hong, S. H., Park, C., Kim, B. W., & Choi, Y. H. (2017) · Drug Discoveries & Therapeutics · doi:10.5582/ddt.2017.01046 · Cited by 20
Ihn, H. J., Kim, J., Cho, H. S., Shin, H., Kim, G., Choi, Y. H., Jeon, Y., & Park, E. K. (2017) · International Journal of Molecular Sciences · doi:10.3390/ijms18122635 · Cited by 18
Self-citationGaidhu, M. P., & Ceddia, R. B. (2009) · Clinical Lipidology · doi:10.2217/clp.09.30 · Cited by 12
AMP-activated protein kinase and its regulation by adiponectin and interleukin-6
Kelly, M., Ruderman, N. B., & Tomás, E. (2006) · Scandinavian Journal of Food & Nutrition · doi:10.1080/17482970601076305 · Cited by 11
Anti-inflammatory effect of supercritical extract and its constituents from Ishige okamurae
Ko, E.-Y., Yoon, W., Lee, H., Heo, S., Ko, Y.-H., Fernando, I. P. S., Cho, K., Lee, C.-H., Hur, S., Cho, S.-H., et al. (2016) · EXCLI journal · doi:10.17179/excli2016-337 · Cited by 9
Flagged first, then by citations
Cited by
Sorted by citations
Carroll, A. R., Copp, B. R., Davis, R. A., Keyzers, R. A., & Prinsep, M. R. (2021) · Natural Product Reports · doi:10.1039/d0np00089b · Cited by 348
Mondo, A. D., Smerilli, A., Ambrosino, L., Albini, A., Noonan, D. M., Sansone, C., & Brunet, C. (2021) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2021.1874284 · Cited by 148
Hosseini, S. F., Rezaei, M., & McClements, D. J. (2020) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2020.1839855 · Cited by 91
Lee, H.-G., Lu, Y., Li, X., Hyun, J., Kim, H., Lee, J. J., Kim, T. H., Kim, H. M., Kang, M., & Jeon, Y. (2020) · Nutrients · doi:10.3390/nu12020308 · Cited by 72
Self-citationWang, L., Kim, H. S., Oh, J. Y., Je, J.-G., Jeon, Y., & Ryu, B. (2019) · Food and Chemical Toxicology · doi:10.1016/j.fct.2019.110963 · Cited by 72
Self-citationFernando, I. P. S., Ryu, B., Ahn, G., Yeo, I., & Jeon, Y. (2020) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2020.01.020 · Cited by 68
Self-citationAnti-obesity effects of red seaweed, Plocamium telfairiae , in C57BL/6 mice fed a high-fat diet
Lu, Y., Lee, H.-G., Li, X., Hyun, J., Kim, H., Kim, T. H., Kim, H.-M., Lee, J. J., Kang, M., & Jeon, Y. (2020) · Food & Function · doi:10.1039/c9fo02924a · Cited by 50
Self-citationMayer, A. M. S., Mayer, V. A., Swanson-Mungerson, M. A., Pierce, M. L., Rodrı́guez, A. D., Nakamura, F., & Taglialatela‐Scafati, O. (2024) · Marine Drugs · doi:10.3390/md22070309 · Cited by 51
Therapeutic Potential of Seaweed-Derived Bioactive Compounds for Cardiovascular Disease Treatment
Cho, C. H., Lu, Y., Kim, M., Jeon, Y., & Lee, S. (2022) · Applied Sciences · doi:10.3390/app12031025 · Cited by 46
Self-citationAnti-Obesity and Anti-Diabetic Effects of Ishige okamurae
Yang, H.-W., Fernando, K. H. N., Oh, J.-Y., Li, X., Jeon, Y., & Ryu, B. (2019) · Marine Drugs · doi:10.3390/md17040202 · Cited by 44
Self-citationKim, S.-Y., Ahn, G., Kim, H., Je, J.-G., Kim, K., & Jeon, Y. (2020) · Marine Drugs · doi:10.3390/md18110529 · Cited by 38
Self-citationDing, Y., Wang, L., Im, S.-T., Hwang, O., Kim, H.-S., Kang, M., & Lee, S. (2019) · Marine Drugs · doi:10.3390/md17110637 · Cited by 35
Self-citationSeparation and Lipid Inhibition Effects of a Novel Decapeptide from Chlorella pyenoidose
Zhang, R., Chen, J., Mao, X., Qi, P., & Zhang, X. (2019) · Molecules · doi:10.3390/molecules24193527 · Cited by 34
Lu, Y., Jiang, Y., Yang, H.-W., Hwang, J., Jeon, Y., & Ryu, B. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms22041610 · Cited by 28
Self-citationChen, L., Liu, R., He, X., Pei, S., & Li, D. (2021) · Food & Function · doi:10.1039/d0fo02886j · Cited by 27
Lee, H.-G., Kim, H., Je, J.-G., Hwang, J., Sanjeewa, K. K. A., Lee, D.-S., Song, K., Choi, Y., Kang, M., & Jeon, Y. (2021) · Marine Drugs · doi:10.3390/md19020096 · Cited by 25
Self-citationKojima‐Yuasa, A., & Matsui‐Yuasa, I. (2020) · Journal of Medicinal Food · doi:10.1089/jmf.2019.4490 · Cited by 22
Jian, T., Lv, H., Ding, X., Wu, Y., Zuo, Y., Li, J., Chen, J., & Gu, H. (2019) · PeerJ · doi:10.7717/peerj.8165 · Cited by 22
Intramuscular fat deposition in pig: A key target for improving pork quality
Han, Q., Huang, X., He, J., Zeng, Y., Yin, J., & Yin, Y. (2024) · Journal of Integrative Agriculture · doi:10.1016/j.jia.2024.03.005 · Cited by 20
α-Glucosidase Inhibitory Activity and Anti-Adipogenic Effect of Compounds from Dendrobium delacourii
Thant, M. T., Khine, H. E. E., Nealiga, J. Q. L., Chatsumpun, N., Chaotham, C., Sritularak, B., & Likhitwitayawuid, K. (2022) · Molecules · doi:10.3390/molecules27041156 · Cited by 15
Wang, X., Di, W., Wang, Z., Qi, P., Liu, Z., Zhao, H., Ding, W., & Di, S. (2024) · Journal of Hazardous Materials · doi:10.1016/j.jhazmat.2024.135560 · Cited by 14
Maitreesophone, P., Khine, H. E. E., Nealiga, J. Q. L., Kongkatitham, V., Panuthai, P., Chaotham, C., Likhitwitayawuid, K., & Sritularak, B. (2021) · South African Journal of Botany · doi:10.1016/j.sajb.2021.10.025 · Cited by 11
Treatment of Obese Zebrafish with Saringosterol Acetate through AMP Activated Protein Kinase Pathway
Zhou, D., Fu, Y., Li, F., Yang, D., Wei, L., Yue, H., Dai, Y., & Jeon, Y. (2022) · Chemistry & Biodiversity · doi:10.1002/cbdv.202200495 · Cited by 8
Self-citationMarine metabolites: oceans of opportunity
Facey, P. C., & Gallimore, W. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-443-18657-8.00027-x · Cited by 7
Song, X., Han, L., Lin, X., Tian, M., Sun, F., & Feng, B. (2022) · Annals of Translational Medicine · doi:10.21037/atm-22-685 · Cited by 5
Multifunctional Microneedle Patch with Diphlorethohydroxycarmalol for Potential Wound Dressing
Kim, T., Kim, M., Kim, N.-G., Linh, N. V., Doan, H. V., Kim, Y.-M., Park, S., & Jung, W. (2024) · Tissue Engineering and Regenerative Medicine · doi:10.1007/s13770-024-00655-z · Cited by 7
Bak, S. G., Lim, H. J., Park, E. J., Won, Y., Lee, S. W., Ryu, B., Ha, H. J., Cheong, S. H., & Lee, S. (2023) · Revista Brasileira de Farmacognosia · doi:10.1007/s43450-023-00488-2 · Cited by 5
Self-citationChoi, H., Choi, J.-H., Jang, Y., Lee, Y., Kang, M.-H., Kwon, H.-S., Kim, S., & Kwon, J. (2024) · Applied Sciences · doi:10.3390/app14156412 · Cited by 4
Self-citationWang, Y.-Q., Lin, Z., Zhang, H., Gao, Y., Liu, Y., & Liang, J. (2026) · Marine Drugs · doi:10.3390/md24060208 · Cited by 2
Kim, M., Lee, W., Kim, K., Kim, Y., Jeon, Y., Yang, F., Kim, S.-Y., & Lee, H.-G. (2025) · Marine Drugs · doi:10.3390/md23100376 · Cited by 1
Self-citationFelemban, A. H., Alshammari, G. M., Yagoub, A. E. A., Saleh, A. Y., & Yahya, M. A. (2024) · Nutrients · doi:10.3390/nu16183174 · Cited by 1
Marine Natural Products and Obesity
Urbatzka, R., & Vasconcelos, V. M. (2019) · MDPI eBooks · doi:10.3390/books978-3-03921-192-0 · Cited by 1
Efimtseva, Ė. A., & Chelpanova, T. I. (2026) · Human Physiology · doi:10.1134/s0362119726700398
Metadata
- Authors
- Kang, M.-C., Ding, Y., Kim, H.-S., Jeon, Y.-J., & Lee, S.-H.
- Affiliations
- Korea Food Research Institute (KR)
- Soonchunhyang University (KR)
- Jeju National University (KR)
- Corresponding author
- Lee, Seung-Hong
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2019-01-10
- Volume
- 17
- Issue
- 1
- Pages
- 44
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC6356311
- OpenAlex
- W2909539549
- Cited by
- 37
- References
- 32
- Citations by year
- 2026: 2 · 2025: 1 · 2024: 6 · 2023: 2 · 2022: 4 · 2021: 6 · 2020: 6 · 2019: 10
- FWCI
- 5.79
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Peroxisome Proliferator-Activated Receptors
- Health Sciences › Medicine › Pharmacology (medical) › Pharmacology and Obesity Treatment
- Keywords
- adipogenesis inhibition, AMPK activation, 3T3-L1 adipocytes, lipid accumulation, fatty acid synthesis, SREBP-1c, PPARγ, adiponectin, acetyl-CoA carboxylase, anti-obesity, marine natural products
- MeSH terms
- Adenylate Kinase, Animals, Cell Survival, Heterocyclic Compounds, 3-Ring, Seaweed, Molecular Structure, Gene Expression Regulation, Enzymologic, Adipocytes, 3T3-L1 Cells, Adipogenesis, Mice
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
