The Anti-Photoaging Activity of Peptides from Pinctada martensii Meat
Open accessAbstract
Long-term exposure to ultraviolet-B (UVB) can cause photoaging. Peptides from Pinctada martensii meat have been shown to have anti-photoaging activities, but their mechanism of action is rarely studied. In this study, Pinctada martensii meat hydrolysates (PME) were prepared by digestive enzymes and then separated by ultrafiltration and Sephadex G-25 gel filtration chromatography to obtain a purified fraction (G2). The fraction G2 was identified by ultra-performance liquid chromatography tandem mass spectrometry (UHPLC-MS/MS), and peptide sequences were synthesized by solid-phase synthesis. The mechanism of anti-photoaging activities was investigated using a human immortalised epidermal (HaCaT) cell model. Results showed that peptides from Pinctada martensii meat increased UVB-induced cell viability and reduced the contents of interstitial collagenase (MMP-1) and matrix lysing enzyme (MMP-3) in HaCaT cells. Furthermore, the fraction of G2 significantly downregulated the expression of p38, EKR, JNK, MMP-1, and MMP-3 in HaCaT cells. The peptide sequences Phe-His (FH), Ala-Leu (AL), Met-Tyr (MY), Ala-Gly-Phe (AGF), and Ile-Tyr-Pro (IYP) were identified and synthesized. Besides, FH reduced the contents of MMP-1 and MMP-3 in HaCaT cells, combining them effectively in molecular docking analysis. Thus, peptides from Pinctada martensii meat showed anti-photoaging activities and might have the potential to be used as an anti-photoaging agent in functional foods.
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Wei et al.'s study is classified as Level 3 (small case-control study) according to Oxford CEBM.
“The level of evidence is classified as Level 3 ‐ small case‐control study (according to the Oxford Centre for Evidence‐Based Medicine).”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [54]
The Materials and Methods section (3.5; page not specified) describes UVB irradiation of cultured HaCaT cells, and the Results (2.3; page not specified) report laboratory assays on those cells. This is an experimental cell study, not a small case-control study. The paper does not give itself an Oxford CEBM Level 3 classification. (LLM, conf=0.88)
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Experimental — accuracy not yet measuredWei et al. found that peptides derived from Pinctada martensii meat demonstrated significant potential in protecting skin from photoaging.
“The researchers found that these peptides demonstrated significant potential in protecting skin from photoaging, providing a novel and promising avenue for skincare products.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [54]
Wei et al.'s study did not fully elucidate mechanisms of action of the peptides.
“Additionally, the mechanisms of action of these peptides were not fully elucidated in the study, raising questions about how exactly they exert their anti‐photoaging effects.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [54]
Wei et al.'s study had a non-robust sample size.
“The sample size was not robust, and further research with larger sample sizes and longer follow‐up periods is needed to confirm the efficacy and safety of these peptides in preventing photoaging.”
From Cosmeceuticals in photoaging: A review. (2024) · cites this paper as [54]
The Statistical Analysis section (no page number available) reports at least three technical and three biological replicates, but does not assess whether that number was robust. Searches for a small-sample limitation and a recommendation for larger samples or longer follow-up found no supporting passage in our copy. (LLM, conf=0.72)
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- Authors
- Wei, M., Qiu, H., Zhou, J., Yang, C., Chen, Y., & You, L.
- Affiliations
- South China University of Technology (CN)
- School of Food Science and Engineering, South China University of Technology, Guangzhou 510640, China
- Arizona State University (US)
- Corresponding author
- You, Lijun
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2022-12-08
- Volume
- 20
- Issue
- 12
- Pages
- 770
- ISSN
- 1660-3397 (ISSN-L)
- PMC
- PMC9788596
- OpenAlex
- W4311856809
- Cited by
- 33
- References
- 44
- Citations by year
- 2026: 5 · 2025: 13 · 2024: 11 · 2023: 4
- FWCI
- 2.29
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Marine Drugs (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- 2021 Special funds of Guangdong Province for Promoting Economic Development (GDNRC [2021]49)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Protein Hydrolysis and Bioactive Peptides
- Health Sciences › Medicine › Dermatology › Skin Protection and Aging
- Health Sciences › Medicine › Physiology › Biochemical effects in animals
- Keywords
- Pinctada martensii, UV-B radiation, HaCaT keratinocytes, MMP-1, matrix metalloproteinase-3, p38 MAPK, JNK, ERK, collagen degradation, functional food ingredients, peptide identification, molecular docking
- MeSH terms
- Animals, Humans, Meat, Peptides, Ultraviolet Rays, Skin Aging, Matrix Metalloproteinase 3, Matrix Metalloproteinase 1, Pinctada, Tandem Mass Spectrometry, Molecular Docking Simulation
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