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Cited by 117Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSeaweed-derived Bioactive Compounds

The DOI matches its Crossref record; 26 of the 26 references it cites were found in a registry or an index.

Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus

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Martins, Rosário, Ramos, Miguel, Herfindal, Lars, Sousa, José, Skærven, Kaja, Vasconcelos, Vitor·2008·Marine Drugs
DOI 10.3390/md6010001
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Abstract

Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.

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  1. Moore, R.E.; Patterson, G.M.L.; Carmichael, W.W. New pharmaceuticals from cultured blue-green algae. In Biomedical importance of marine organisms; Fautin, D.G., Ed.; Mem. Cal. Acad. Sci., 1988; Volume 13, pp. 143-150.

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Metadata

Authors
Martins, R., Ramos, M., Herfindal, L., Sousa, J., Skærven, K., & Vasconcelos, V.
Affiliations
  • Universidade do Porto (PT)
  • University of Bergen (NO)
  • Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway
Corresponding author
Vasconcelos, Vitor
ORCID
Venue
Marine Drugs
Publisher
MDPI AG
Published
2008-01-22
Volume
6
Issue
1
Pages
1-11
ISSN
1660-3397 (ISSN-L)
DOI
10.3390/md6010001
OpenAlex
W4297835311
Cited by
117
References
26
Citations by year
2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 2
FWCI
2.57
Type
journal article
Language
en
Open access
Licence
Locations
  • Marine Drugs (publishedVersion, cc-by)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics
  • Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
  • Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords
marine cyanobacteria, Synechocystis, Synechococcus, antimicrobial activity, cytotoxicity, apoptosis, HL-60 cells, rat hepatocytes, Cellulomonas uda, Candida albicans, Gram-positive bacteria, organic solvent extracts, aqueous extract, natural products

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