Cited by 117Microbial Natural Products and BiosynthesisMarine Sponges and Natural ProductsSeaweed-derived Bioactive Compounds

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Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus

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Martins, Rosário, Ramos, Miguel, Herfindal, Lars, Sousa, José, Skærven, Kaja, Vasconcelos, Vitor·2008·Marine Drugs

DOI 10.3390/md6010001

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Abstract

Aqueous extracts and organic solvent extracts of isolated marine cyanobacteria strains were tested for antimicrobial activity against a fungus, Gram-positive and Gram-negative bacteria and for cytotoxic activity against primary rat hepatocytes and HL-60 cells. Antimicrobial activity was based on the agar diffusion assay. Cytotoxic activity was measured by apoptotic cell death scored by cell surface evaluation and nuclear morphology. A high percentage of apoptotic cells were observed for HL-60 cells when treated with cyanobacterial organic extracts. Slight apoptotic effects were observed in primary rat hepatocytes when exposed to aqueous cyanobacterial extracts. Nine cyanobacteria strains were found to have antibiotic activity against two Gram-positive bacteria, Clavibacter michiganensis subsp. insidiosum and Cellulomonas uda. No inhibitory effects were found against the fungus Candida albicans and Gram-negative bacteria. Marine Synechocystis and Synechococcus extracts induce apoptosis in eukaryotic cells and cause inhibition of Gram-positive bacteria. The different activity in different extracts suggests different compounds with different polarities.

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Authors: Martins, R., Ramos, M., Herfindal, L., Sousa, J., Skærven, K., & Vasconcelos, V.
Affiliations: Universidade do Porto (PT)
University of Bergen (NO)
Department of Biomedicine, University of Bergen, Jonas Lies vei 91, N-5009 Bergen, Norway
Corresponding author: Vasconcelos, Vitor
ORCID: Martins, Rosário
Ramos, Miguel
Herfindal, Lars
Sousa, José
Vasconcelos, Vitor
Venue: Marine Drugs
Publisher: MDPI AG
Published: 2008-01-22
Volume: 6
Issue: 1
Pages: 1-11
ISSN: 1660-3397 (ISSN-L)
DOI: 10.3390/md6010001
OpenAlex: W4297835311
Cited by: 117
References: 26
Citations by year: 2026: 1 · 2025: 4 · 2024: 5 · 2023: 8 · 2022: 12 · 2021: 9 · 2020: 12 · 2019: 6 · 2018: 9 · 2017: 7 · 2016: 7 · 2015: 10 · 2014: 5 · 2013: 9 · 2012: 2
FWCI: 2.57
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/3.0/ (vor)
Locations: Marine Drugs (publishedVersion, cc-by)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Topics: Life Sciences › Immunology and Microbiology › Applied Microbiology and Biotechnology › Microbial Natural Products and Biosynthesis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Biotechnology › Marine Sponges and Natural Products
Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
Keywords: marine cyanobacteria, Synechocystis, Synechococcus, antimicrobial activity, cytotoxicity, apoptosis, HL-60 cells, rat hepatocytes, Cellulomonas uda, Candida albicans, Gram-positive bacteria, organic solvent extracts, aqueous extract, natural products

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Antimicrobial and Cytotoxic Assessment of Marine Cyanobacteria - Synechocystis and Synechococcus

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