The DOI matches its Crossref record; 8 of the 8 references it cites were found in a registry or an index.
Astaxanthin: A Potential Therapeutic Agent in Cardiovascular Disease
Open accessAbstract
Astaxanthin is a xanthophyll carotenoid present in microalgae, fungi, complex plants, seafood, flamingos and quail. It is an antioxidant with anti-inflammatory properties and as such has potential as a therapeutic agent in atherosclerotic cardiovascular disease. Synthetic forms of astaxanthin have been manufactured. The safety, bioavailability and effects of astaxanthin on oxidative stress and inflammation that have relevance to the pathophysiology of atherosclerotic cardiovascular disease, have been assessed in a small number of clinical studies. No adverse events have been reported and there is evidence of a reduction in biomarkers of oxidative stress and inflammation with astaxanthin administration. Experimental studies in several species using an ischaemia-reperfusion myocardial model demonstrated that astaxanthin protects the myocardium when administered both orally or intravenously prior to the induction of the ischaemic event. At this stage we do not know whether astaxanthin is of benefit when administered after a cardiovascular event and no clinical cardiovascular studies in humans have been completed and/or reported. Cardiovascular clinical trials are warranted based on the physicochemical and antioxidant properties, the safety profile and preliminary experimental cardiovascular studies of astaxanthin.
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(1994) · New England Journal of Medicine · doi:10.1056/nejm199404143301501 · Cited by 4,737
Effects of a combination of beta carotene and vitamin A on lung cancer and cardiovascular disease
Omenn, G. S., Goodman, G. E., Thornquist, M. D., Balmes, J., Cullen, M. R., Glass, A., Keogh, J. P., Meyskens, F. L., Valanis, B., Williams, J. H., et al. (1996) · New England Journal of Medicine · doi:10.1056/nejm199605023341802 · Cited by 3,638
Stephens, N. G., Parsons, A., Brown, M. J., Schofield, P. M., Kelly, F., Cheeseman, K., & Mitchinson, M. (1996) · The Lancet · doi:10.1016/s0140-6736(96)90866-1 · Cited by 2,148
Brown, B. G., Zhao, X.-Q., Chait, A., Fisher, L. D., Cheung, M. C., Morse, J. S., Dowdy, A. A., Marino, E. K., Bolson, E. L., Alaupovic, P., et al. (2001) · New England Journal of Medicine · doi:10.1056/nejmoa011090 · Cited by 1,979
Vitamin E Supplementation and Cardiovascular Events in High-Risk Patients
(2000) · New England Journal of Medicine · doi:10.1056/nejm200001203420302 · Cited by 1,957
Beutner, S., Bloedorn, B., Frixel, S., Hernández Blanco, I., Hoffmann, T., Martin, H., Mayer, B., Noack, P., Ruck, C., Schmidt, M., et al. (2001) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.849 · Cited by 253
Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis
Kamath, B. S., Srikanta, B. M., Dharmesh, S. M., Sarada, R., & Ravishankar, G. A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.042 · Cited by 162
Cited by
Camacho, F., Macedo, A., & Malcata, F. (2019) · Marine Drugs · doi:10.3390/md17060312 · Cited by 409
Carotenoids: potential allies of cardiovascular health?
Maria, A. G., Graziano, R., & Nicolantonio, D. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.26762 · Cited by 323
Functions, Therapeutic Applications, and Synthesis of Retinoids and Carotenoids
Álvarez, R., Vaz, B., Gronemeyer, H., & de Lera, Á. R. (2014) · Chemical Reviews · doi:10.1021/cr400126u · Cited by 260
Carotenoids from Marine Microalgae: A Valuable Natural Source for the Prevention of Chronic Diseases
Raposo, M., De Morais, A., & De Morais, R. (2015) · Marine Drugs · doi:10.3390/md13085128 · Cited by 228
Verni, M., Demarinis, C., Rizzello, C. G., & Pontonio, E. (2023) · Foods · doi:10.3390/foods12050983 · Cited by 69
Metadata
- Authors
- Fassett, R. G., & Coombes, J. S.
- Venue
- Marine Drugs
- Publisher
- MDPI AG
- Published
- 2011-03-21
- Volume
- 9
- Issue
- 3
- Pages
- 447-465
- ISSN
- 1660-3397 (ISSN-L)
- OpenAlex
- W2164385726
- Cited by
- 348
- References
- 8
- FWCI
- 9.83
- Type
- journal article
- Language
- en
- Open access
- gold
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
