Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis
Abstract
The anti-ulcer properties of astaxanthin fractions such as total carotenoid and astaxanthin esters from Haematococcus pluvialis were evaluated in ethanol-induced gastric ulcers in rats. Since oxygen radical release is a pathogenic factor of ethanol-induced gastric damage, astaxanthin - a free radical scavenger, was investigated as a potential ulcer preventive agent. Astaxanthin fractions - total carotenoid and astaxanthin esters were orally administered to experimental rats at 100, 250 and 500 microg/kg b.w. prior to ulcer induction. Alcian blue binding assay indicates that, total carotenoid and astaxanthin esters at 500 microg/kg b.w could protect gastric mucin approximately 40% and 67% respectively. Pre-treatment with astaxanthin esters, also resulted in significant increase in antioxidant enzyme levels - catalase, superoxide dismutase, and glutathione peroxidase in stomach homogenate. Histopathological examination substantiated the protective effect of astaxanthin in pre-treated rats. The increased antioxidant potencies such as free radical scavenging activity with an IC(50) of approximately 8 microg/ml and reducing power abilities (59 x 10(3) U/g) in vitro, reveal that H. pluvialis astaxanthin may protect gastric mucosal injury by antioxidative mechanism. In addition, approximately 23 fold increased lipoxygenase-inhibitory property, in comparison with standard astaxanthin and significant H(+), K(+)-ATPase-inhibitory activity of astaxanthin esters, in comparison with known proton pump blocking anti-ulcer drug - omeprazole, may envisage the potential gastroprotective effect by regulating the gastric mucosal injury and gastric acid secretion by the gastric cell during ulcer disease.
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Intake of astaxanthin has a protective effect against ethanol-induced gastric ulcers caused by Helicobacter pylori.
“The intake of astaxanthin has been shown to have a protective effect against ethanol-induced gastric ulcers caused by Helicobacter pylori (Kamath et al., 2008) and affects cholesterol levels in blood, which could be helpful for curing heart disease (Olaizola, 2005), preventing obesity (Ikeuchi et al., 2007) and preventing age-related cognitive function in humans (Satoh et al., 2009).”
From Microalgae Metabolites: A Rich Source for Food and Medicine (2019) · cites this paper as Kamath et al., 2008
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- Authors
- Kamath, B. S., Srikanta, B. M., Dharmesh, S. M., Sarada, R., & Ravishankar, G. A.
- Affiliations
- Central Food Technological Research Institute (IN)
- Corresponding author
- Dharmesh, Shylaja Mallaiah
- Venue
- European Journal of Pharmacology
- Publisher
- Elsevier BV
- Published
- 2008-08
- Volume
- 590
- Issue
- 1-3
- Pages
- 387-395
- ISSN
- 0014-2999 (ISSN-L)
- OpenAlex
- W2087838127
- Cited by
- 162
- References
- 48
- Citations by year
- 2026: 4 · 2025: 9 · 2024: 10 · 2023: 7 · 2022: 16 · 2021: 18 · 2020: 11 · 2019: 12 · 2018: 11 · 2017: 4 · 2016: 13 · 2015: 7 · 2014: 5 · 2013: 3 · 2012: 10
- FWCI
- 4.46
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- European Journal of Pharmacology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- Council of Scientific and Industrial Research, India
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Life Sciences › Agricultural and Biological Sciences › Aquatic Science › Seaweed-derived Bioactive Compounds
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- astaxanthin, Haematococcus pluvialis, gastric ulcer, ethanol-induced gastric injury, gastroprotection, antioxidant activity, free radical scavenging, astaxanthin esters, carotenoids, gastric mucin, antioxidant enzymes, lipoxygenase inhibition, H+/K+-ATPase inhibition, gastric acid secretion, oxidative stress
- MeSH terms
- Chlorophyta, Animals, Anti-Ulcer Agents, Antioxidants, Carotenoids, Female, Gastric Mucosa, Male, Stomach Ulcer, Lipid Peroxidation, Lipoxygenase Inhibitors, Rats, Wistar, Xanthophylls, Rats, Proton Pump Inhibitors
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