Interaction of plant extracts with central nervous system receptors
Open accessAbstract
Background: Plant extracts have been used in traditional medicine for the treatment of various maladies including neurological diseases. Several central nervous system receptors have been demonstrated to interact with plant extracts and components affecting the pharmacology and thereby potentially playing a role in human disease and treatment. For instance, extracts from Hypericum perforatum (St. John’s wort) targeted several CNS receptors. Similarly, extracts from Piper nigrum, Stephania cambodica, and Styphnolobium japonicum exerted inhibition of agonist-induced activity of the human neurokinin-1 receptor. Methods: Different methods have been established for receptor binding and functional assays based on radioactive and fluorescence-labeled ligands in cell lines and primary cell cultures. Behavioral studies of the effect of plant extracts have been conducted in rodents. Plant extracts have further been subjected to mood and cognition studies in humans. Results: Mechanisms of action at molecular and cellular levels have been elucidated for medicinal plants in support of standardization of herbal products and identification of active extract compounds. In several studies, plant extracts demonstrated affinity to a number of CNS receptors in parallel indicating the complexity of this interaction. In vivo studies showed modifications of CNS receptor affinity and behavioral responses in animal models after treatment with medicinal herbs. Certain plant extracts demonstrated neuroprotection and enhanced cognitive performance, respectively, when evaluated in humans. Noteworthy, the penetration of plant extracts and their protective effect on the blood-brain-barrier are discussed. Conclusion: The affinity of plant extracts and their isolated compounds for CNS receptors indicates an important role for medicinal plants in the treatment of neurological disorders. Moreover, studies in animal and human models have confirmed a scientific basis for the application of medicinal herbs. However, additional investigations related to plant extracts and their isolated compounds, as well as their application in animal models and the conducting of clinical trials, are required.
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Animal and human research have shown a scientific foundation for the use of therapeutic plants.
“Furthermore, animal and human research have shown a scientific foundation for the use of therapeutic plants.[9 , 10]”
From Phytotherapy: A promising approach for the treatment of Alzheimer's disease (2022) · cites this paper as [9]
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- Authors
- Lundstrom, K., Pham, H., & Dinh, L.
- Affiliations
- PanTherapeutics, 1095 Lutry, Switzerland
- Ministry of Health (VN)
- Vietnam National University, Hanoi (VN)
- Corresponding author
- Lundstrom, Kenneth
- ORCID
- Lundstrom, Kenneth
- Venue
- Medicines
- Publisher
- MDPI AG
- Published
- 2017-02-23
- Volume
- 4
- Issue
- 1
- Pages
- 12
- ISSN
- 2305-6320 (ISSN-L)
- PMC
- PMC5597072
- OpenAlex
- W2589505346
- Cited by
- 55
- References
- 64
- Citations by year
- 2026: 5 · 2025: 6 · 2024: 6 · 2023: 8 · 2022: 4 · 2021: 10 · 2020: 6 · 2019: 5 · 2018: 5
- FWCI
- 0.94
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Medicines (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- plant extracts, central nervous system receptors, medicinal plants, neurokinin-1 receptor, Hypericum perforatum, black pepper, Styphnolobium japonicum, neuroprotection, cognitive enhancement, blood-brain barrier, receptor binding assay, herbal medicine standardization, neurological disorders
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