Cited by 60Epilepsy research and treatmentMedicinal Plant Extracts EffectsMedicinal Plant Research

A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy

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Sharifi-Rad, Javad, Quispe, Cristina, Herrera-Bravo, Jesús, Martorell, Miquel, Sharopov, Farukh, Tumer, Tugba Boyunegmez, Kurt, Begum, Lankatillake, Chintha +8 more·2021·Neurochemical Research

Abstract

Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.

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Crossref · 10.1007/s11064-021-03376-0

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Authors
Sharifi-Rad, J., Quispe, C., Herrera-Bravo, J., Martorell, M., Sharopov, F., Tumer, T. B., Kurt, B., Lankatillake, C., Docea, A. O., Moreira, A. C., Dias, D. A., Mahomoodally, M. F., Lobine, D., Cruz-Martins, N., Kumar, M., & Calina, D.
Affiliations
  • Arturo Prat University (CL)
  • University of Concepción (CL)
  • Tajik State Medical University (TJ)
  • Çanakkale Onsekiz Mart Üniversitesi (TR)
  • RMIT University (AU)
  • University of Medicine and Pharmacy of Craiova (RO)
  • Hospital Garcia de Orta (PT)
  • University of Mauritius (MU)
  • ICAR - Central Institute for Research on Cotton Technology (IN)
Corresponding author
Dias, Daniel A.
Venue
Neurochemical Research
Published
2021-06-12
Volume
46
Issue
9
Pages
2205-2225
ISSN
  • 0364-3190 (ISSN-L)
  • 1573-6903
OpenAlex
W3168323454
Cited by
60
References
121
Citations by year
2026: 4 · 2025: 7 · 2024: 5 · 2023: 16 · 2022: 23 · 2021: 5
FWCI
2.18
Type
journal article
Language
en
Open access
Locations
  • Neurochemical Research (publishedVersion)
  • PubMed (publishedVersion)
  • Çanakkale Onsekiz Mart University AVESIS (submittedVersion)
  • Çanakkale Onsekiz Mart University Institutional Repository (submittedVersion)
  • RMIT Research Repository (RMIT University Library) (submittedVersion)
  • Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
Topics
  • Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
  • Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
epilepsy, anticonvulsant activity, phytochemicals, natural products, flavonoids, alkaloids, terpenoids, complementary therapy, structure-activity relationship, antiepileptic drugs, seizure models
MeSH terms
Alkaloids, Animals, Anticonvulsants, Epilepsy, Flavonoids, Humans, Plant Extracts, Plants, Medicinal, Seizures, Terpenes, Phytochemicals

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