A Pharmacological Perspective on Plant-derived Bioactive Molecules for Epilepsy
Open accessAbstract
Epilepsy is a related chronic neurological condition of a predisposition for recurrent epileptic seizures, with various manifestations and causes. Although there are antiepileptic drugs, complementary natural therapies are widely used. The purpose of this systematic review was to analyze the antiepileptic/anticonvulsant pharmacological properties of plant-food derived bioactive molecules. In this regard, a systematic review of the PubMed database was made based on the inclusion criteria. Natural compounds/herbs with scientifically proven antiepileptic properties were selected. Experimental pharmacological studies in vitro and in vivo have shown that flavonoids, alkaloids and terpenoids may have anticonvulsant mechanisms similar to the new generation antiepileptic drugs. The relationships of structure-anticonvulsant effect, pharmacological models, seizure-inducing factors and response, effective dose were also analyzed and discussed. The results of in vitro and in vivo pharmacological studies analyzed in this systematic review support the clinical importance of plant-food-derived bioactive molecules for the complementary treatment of epilepsy. Thus, are opened new perspectives to develop new natural anticonvulsant drugs.
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The brain, as a highly metabolically active organ, generates a high amount of reactive oxygen species.
“The brain, as high metabolically active organ, generates a high amount of ROS [25].”
From Multi-Target Mechanisms of Phytochemicals in Alzheimer’s Disease: Effects on Oxidative Stress, Neuroinflammation and Protein Aggregation (2022) · cites this paper as [25]
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Sharifi-Rad, J., Rapposelli, S., Sestito, S., Herrera-Bravo, J., Arancibia-Diaz, A., Salazar, L. A., Yeskaliyeva, B., Beyatli, A., Leyva-Gómez, G., González-Contreras, C., et al. (2022) · Journal of Personalized Medicine · doi:10.3390/jpm12091515 · Cited by 125 · see citing works
“The brain, as high metabolically active organ, generates a high amount of ROS [25].”
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Self-citationReversal of brain aging by targeting telomerase: A nutraceutical approach
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Self-citation
- Authors
- Sharifi-Rad, J., Quispe, C., Herrera-Bravo, J., Martorell, M., Sharopov, F., Tumer, T. B., Kurt, B., Lankatillake, C., Docea, A. O., Moreira, A. C., Dias, D. A., Mahomoodally, M. F., Lobine, D., Cruz-Martins, N., Kumar, M., & Calina, D.
- Affiliations
- Arturo Prat University (CL)
- University of Concepción (CL)
- Tajik State Medical University (TJ)
- Çanakkale Onsekiz Mart Üniversitesi (TR)
- RMIT University (AU)
- University of Medicine and Pharmacy of Craiova (RO)
- Hospital Garcia de Orta (PT)
- University of Mauritius (MU)
- ICAR - Central Institute for Research on Cotton Technology (IN)
- Corresponding author
- Dias, Daniel A.
- ORCID
- Venue
- Neurochemical Research
- Published
- 2021-06-12
- Volume
- 46
- Issue
- 9
- Pages
- 2205-2225
- ISSN
- 0364-3190 (ISSN-L)
- 1573-6903
- OpenAlex
- W3168323454
- Cited by
- 60
- References
- 121
- Citations by year
- 2026: 4 · 2025: 7 · 2024: 5 · 2023: 16 · 2022: 23 · 2021: 5
- FWCI
- 2.18
- Type
- journal article
- Language
- en
- Open access
- green
- repositorio.ufro.cl
- Licence
- Locations
- Neurochemical Research (publishedVersion)
- PubMed (publishedVersion)
- Çanakkale Onsekiz Mart University AVESIS (submittedVersion)
- Çanakkale Onsekiz Mart University Institutional Repository (submittedVersion)
- RMIT Research Repository (RMIT University Library) (submittedVersion)
- Omeka S (Universidad de La Frontera) (submittedVersion, cc-by-nc-nd)
- Topics
- Health Sciences › Medicine › Psychiatry and Mental health › Epilepsy research and treatment
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
- Keywords
- epilepsy, anticonvulsant activity, phytochemicals, natural products, flavonoids, alkaloids, terpenoids, complementary therapy, structure-activity relationship, antiepileptic drugs, seizure models
- MeSH terms
- Alkaloids, Animals, Anticonvulsants, Epilepsy, Flavonoids, Humans, Plant Extracts, Plants, Medicinal, Seizures, Terpenes, Phytochemicals
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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