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Polymeric Plant-derived Excipients in Drug Delivery
Open accessAbstract
Drug dosage forms contain many components in addition to the active pharmaceutical ingredient(s) to assist in the manufacturing process as well as to optimise drug delivery. Due to advances in drug delivery technology, excipients are currently included in novel dosage forms to fulfil specific functions and in some cases they directly or indirectly influence the extent and/or rate of drug release and absorption. Since plant polysaccharides comply with many requirements expected of pharmaceutical excipients such as non-toxicity, stability, availability and renewability they are extensively investigated for use in the development of solid oral dosage forms. Furthermore, polysaccharides with varying physicochemical properties can be extracted from plants at relatively low cost and can be chemically modified to suit specific needs. As an example, many polysaccharide-rich plant materials are successfully used as matrix formers in modified release dosage forms. Some natural polysaccharides have even shown environmental-responsive gelation characteristics with the potential to control drug release according to specific therapeutic needs. This review discusses some of the most important plant-derived polymeric compounds that are used or investigated as excipients in drug delivery systems.
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Cites
Pectins: structure, biosynthesis, and oligogalacturonide-related signaling
Ridley, B. L., O'Neill, M. A., & Mohnen, D. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00113-3 · Cited by 1,912
Carbohydrate terminology and classification
Cummings, J. H., & Stephen, A. M. (2007) · European Journal of Clinical Nutrition · doi:10.1038/sj.ejcn.1602936 · Cited by 570
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Polycaprolactone/starch composite: Fabrication, structure, properties, and applications
Ali Akbari Ghavimi, S., Ebrahimzadeh, M. H., Solati-Hashjin, M., & Abu Osman, N. A. (2015) · Journal of Biomedical Materials Research Part A · doi:10.1002/jbm.a.35371 · Cited by 151
Villanova, J. C. O., Ayres, E., Carvalho, S. M., Patrício, P. S., Pereira, F. V., & Oréfice, R. L. (2011) · European Journal of Pharmaceutical Sciences · doi:10.1016/j.ejps.2011.01.005 · Cited by 79
Metadata
- Authors
- Beneke, C. E., Viljoen, A. M., & Hamman, J. H.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2009-07-16
- Volume
- 14
- Issue
- 7
- Pages
- 2602-2620
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W1981465464
- Cited by
- 335
- References
- 2
- FWCI
- 18.78
- Type
- journal article
- Language
- en
- Open access
- gold
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