Cited by 195Essential Oils and Antimicrobial ActivityEdible Oils Quality and AnalysisMedicinal Plant Research

Essential oil of Myrtus communis L. as a potential antioxidant and antimutagenic agents

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Mimica-Dukić, Neda, Bugarin, Dušan, Grbović, Slavenko, Mitić-Ćulafić, Dragana, Vuković-Gačić, Branka, Orčić, Dejan, Jovin, Emilija, Couladis, Maria·2010·Molecules

Abstract

The present study describes DPPH (2,2-diphenyl-1-picrylhydrazyl) radical scavenging activity and antimutagenic properties of the essential oil of myrtle (Myrtus communis L.). Plant samples were collected from the two distant localities (southernmost and northern point) of the Montenegro coastline. Chemical profiles of the two samples were evaluated by GC-MS. In both of the samples monoterpenes were found to be the predominant compounds. Among them alpha-pinene, linalool, 1,8-cineole, and myrtenyl acetate were the major compounds. Significant differences between the samples were found in the ranges of alpha-pinene (14.7%-35.9%) and myrtenyl acetate (5.4%-21.6%). Both oils exhibited moderate DPPH scavenging activity, with IC50 values of 6.24 mg/mL and 5.99 mg/mL. The antimutagenic properties were assayed against spontaneous and t-BOOH-induced mutagenesis in Escherichia coli oxyR mutant IC202, a bacterial strain deficient in removing ROS. Reduction of the spontaneous mutagenesis in presence of myrtle EO was only slight, up to 13% at the highest concentration tested. When the oxidative mutagen was used, EO expressed higher reduction of mutagenesis, in a concentration dependent manner, with statistical significance for effect at the highest concentration tested (28%). Suppression of t-BOOH induced mutagenesis was correlated with the observed scavenging activity.

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  • 1,8-cineole and methyl eugenol were identified as the components responsible for the moderate antioxidant activity of Myrtus communis essential oils.

    “The authors identified 1,8-cineole and methyl eugenol as the components responsible for the moderate antioxidant activity of the essential oils of Myrtus communis L..”

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  1. [38]McLafferty F.W. Wiley Registry™ of Mass Spectral Data 7th ed. John Wiley & Sons, Ltd. New York, NY, USA 2005

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Authors
Mimica-Dukić, N., Bugarin, D., Grbović, S., Mitić-Ćulafić, D., Vuković-Gačić, B., Orčić, D., Jovin, E., & Couladis, M.
Affiliations
  • Department of Chemistry, Biochemistry and Environmental Protection, University of Novi Sad Faculty of Sciences. Trg Dositeja Obradovica 3. 21 000 Novi Sad, Serbia
  • University of Novi Sad (RS)
  • University of Belgrade (RS)
  • Chair of Microbiology, Faculty of Biology, University of Belgrade. Studentski Trg 3/II, 11 000 Belgrade, Serbia
  • National and Kapodistrian University of Athens (GR)
Venue
Molecules
Publisher
MDPI AG
Published
2010-04-15
Volume
15
Issue
4
Pages
2759-2770
ISSN
1420-3049 (ISSN-L)
OpenAlex
W2084316454
Cited by
195
References
41
Citations by year
2026: 5 · 2025: 5 · 2024: 14 · 2023: 14 · 2022: 13 · 2021: 11 · 2020: 10 · 2019: 14 · 2018: 14 · 2017: 17 · 2016: 15 · 2015: 13 · 2014: 20 · 2013: 15 · 2012: 6
FWCI
1.14
Type
journal article
Language
en
Open access
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, other-oa)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
Funders
Science and Engineering Research Board
Topics
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Physical Sciences › Chemistry › Organic Chemistry › Edible Oils Quality and Analysis
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Medicinal Plant Research
Keywords
Myrtus communis, myrtle essential oil, antioxidant activity, antimutagenic activity, DPPH radical scavenging, monoterpenes, α-pinene, myrtenyl acetate, linalool, 1,8-cineole, chemical composition, Montenegro coast
MeSH terms
Biphenyl Compounds, Escherichia coli, Free Radicals, Oils, Volatile, Picrates, Repressor Proteins, Free Radical Scavengers, Mutagenesis, Antimutagenic Agents, Escherichia coli Proteins, Myrtus

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