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Cited by 589

The DOI matches its Crossref record; 9 of the 9 references it cites were found in a registry or an index.

Cancer Chemoprevention by Carotenoids

Open access
Tanaka, Takuji, Shnimizu, Masahito, Moriwaki, Hisataka·2012·Molecules
DOI 10.3390/molecules17033202
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Abstract

Carotenoids are natural fat-soluble pigments that provide bright coloration to plants and animals. Dietary intake of carotenoids is inversely associated with the risk of a variety of cancers in different tissues. Preclinical studies have shown that some carotenoids have potent antitumor effects both in vitro and in vivo, suggesting potential preventive and/or therapeutic roles for the compounds. Since chemoprevention is one of the most important strategies in the control of cancer development, molecular mechanism-based cancer chemoprevention using carotenoids seems to be an attractive approach. Various carotenoids, such as β-carotene, a-carotene, lycopene, lutein, zeaxanthin, β-cryptoxanthin, fucoxanthin, canthaxanthin and astaxanthin, have been proven to have anti-carcinogenic activity in several tissues, although high doses of β-carotene failed to exhibit chemopreventive activity in clinical trials. In this review, cancer prevention using carotenoids are reviewed and the possible mechanisms of action are described.

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Metadata

Authors
Tanaka, T., Shnimizu, M., & Moriwaki, H.
Venue
Molecules
Publisher
MDPI AG
Published
2012-03-14
Volume
17
Issue
3
Pages
3202-3242
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules17033202
OpenAlex
W2171237466
Cited by
589
References
9
FWCI
26.16
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Cancer Chemoprevention by Carotenoids. https://app.cochat.ai/papers/10.3390/molecules17033202
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Tanaka, T., Shnimizu, M., & Moriwaki, H. (2012). Cancer Chemoprevention by Carotenoids. Molecules. https://doi.org/10.3390/molecules17033202

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