Potential health-promoting effects of astaxanthin: a high-value carotenoid mostly from microalgae

Astaxanthin: a review of its chemistry and applications

Higuera-Ciapara, I., Félix-Valenzuela, L., & Goycoolea, F. M. (2006) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408690590957188 · Cited by 1,287 · see citing works

Commercial potential for Haematococcus microalgae as a natural source of astaxanthin

Lorenz, R. T., & Cysewski, G. R. (2000) · Trends in biotechnology · doi:10.1016/s0167-7799(00)01433-5 · Cited by 1,190 · see citing works

Antioxidant Activities of Astaxanthin and Related Carotenoids

Naguib, Y. M. A. (2000) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf991106k · Cited by 975 · see citing works

Carotenoid Action on the Immune Response

Chew, B. P., & Park, J. S. (2004) · Journal of Nutrition · doi:10.1093/jn/134.1.257s · Cited by 795 · see citing works

Astaxanthin, a Carotenoid with Potential in Human Health and Nutrition

Hussein, G. M. E., Sankawa, U., Goto, H., Matsumoto, K., & Watanabe, H. (2005) · Journal of Natural Products · doi:10.1021/np050354+ · Cited by 653 · see citing works

Carotenogenesis in the green alga Haematococcus pluvialis : Cellular physiology and stress response

Boussiba, S. (2000) · Physiologia Plantarum · doi:10.1034/j.1399-3054.2000.108002111.x · Cited by 591 · see citing works

Astaxanthin decreased oxidative stress and inflammation and enhanced immune response in humans

Park, J. S., Chyun, J. H., Kim, Y. K., Line, L. L., & Chew, B. P. (2010) · Nutrition & Metabolism · doi:10.1186/1743-7075-7-18 · Cited by 569 · see citing works

Astaxanthin from Microbial Sources

Johnson, E. A., & An, G.-H. (1991) · Critical Reviews in Biotechnology · doi:10.3109/07388559109040622 · Cited by 519 · see citing works

Astaxanthin: A Novel Potential Treatment for Oxidative Stress and Inflammation in Cardiovascular Disease

Pashkow, F. J., Watumull, D. G., & Campbell, C. L. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.010 · Cited by 446 · see citing works

Efficient radical trapping at the surface and inside the phospholipid membrane is responsible for highly potent antiperoxidative activity of the carotenoid astaxanthin

Goto, S., Kogure, K., Abe, K., Kimata, Y., Kitahama, K., Yamashita, E., & Terada, H. (2001) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/s0005-2736(01)00326-1 · Cited by 357 · see citing works

Effects of Astaxanthin on Lipopolysaccharide-Induced Inflammation In Vitro and In Vivo

Ohgami, K., Shiratori, K., Kotake, S., Nishida, T., Mizuki, N., Yazawa, K., & Ohno, S. (2003) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.02-0822 · Cited by 307 · see citing works

Antioxidant intake is associated with semen quality in healthy men

Eskenazi, B., Kidd, S. A., Marks, A. R., Sloter, E. D., Block, G., & Wyrobek, A. J. (2005) · Human Reproduction · doi:10.1093/humrep/deh725 · Cited by 306 · see citing works

Inhibition of Low-Density Lipoprotein Oxidation by Astaxanthin

Iwamoto, T., Hosoda, K., Hirano, R., Kurata, H., Matsumoto, A., Miki, W., Kamiyama, M., Itakura, H., Yamamoto, S., & Kondo, K. N. (2000) · Journal of Atherosclerosis and Thrombosis · doi:10.5551/jat1994.7.216 · Cited by 305 · see citing works

Astaxanthin inhibits nitric oxide production and inflammatory gene expression by suppressing I(kappa)B kinase-dependent NF-kappaB activation.

Lee, S., Bai, S.-K., Lee, K.-S., Namkoong, S., Na, H. J., Ha, K., Han, J. A., Yim, S. V., Chang, K., Kwon, Y. G., et al. (2003) · PubMed · Cited by 279 · see citing works

Differential effects of carotenoids on lipid peroxidation due to membrane interactions: X-ray diffraction analysis

McNulty, H. P., Byun, J., Lockwood, S. F., Jacob, R. F., & Mason, R. P. (2006) · Biochimica et Biophysica Acta (BBA) - Biomembranes · doi:10.1016/j.bbamem.2006.09.010 · Cited by 270 · see citing works

A comparison of the anticancer activities of dietary beta-carotene, canthaxanthin and astaxanthin in mice in vivo.

Chew, B. P., Park, J. S., Wong, M. W., & Wong, T. S. (1999) · PubMed · Cited by 269 · see citing works

Administration of natural astaxanthin increases serum HDL-cholesterol and adiponectin in subjects with mild hyperlipidemia

Yoshida, H., Yanai, H., Ito, K., Tomono, Y., Koikeda, T., Tsukahara, H., & Tada, N. (2010) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2009.10.012 · Cited by 269 · see citing works

ACCUMULATION OF OLEIC ACID IN HAEMATOCOCCUS PLUVIALIS (CHLOROPHYCEAE) UNDER NITROGEN STARVATION OR HIGH LIGHT IS CORRELATED WITH THAT OF ASTAXANTHIN ESTERS 1

Zhekisheva, M., Boussiba, S., Khozin‐Goldberg, I., Zarka, A., & Cohen, Z. (2002) · Journal of Phycology · doi:10.1046/j.1529-8817.2002.01107.x · Cited by 267 · see citing works

Changes in pigments profile in the green alga Haeamtococcus pluvialis exposed to environmental stresses

Boussiba, S., Bing, W., Yuan, J.-P., Zarka, A., & Chen, F. (1999) · Biotechnology Letters · doi:10.1023/a:1005507514694 · Cited by 247 · see citing works

Cis astaxanthin and especially 9-cis astaxanthin exhibits a higher antioxidant activity in vitro compared to the all-trans isomer

Liu, X., & Osawa, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.03.120 · Cited by 242 · see citing works

Carotenoids in Cancer Chemoprevention

Nishino, H., Murakoshi, M., Ii, T., Takemura, M., Kuchide, M., Kanazawa, M., Mou, X., Wada, S., Masuda, M., Ohsaka, Y., et al. (2002) · Cancer and Metastasis Reviews · doi:10.1023/a:1021206826750 · Cited by 226 · see citing works

Antitumor Activity of Astaxanthin and Its Mode of Action

Jyonouchi, H., Sun, S., Iijima, K., & Gross, M. D. (2000) · Nutrition and Cancer · doi:10.1207/s15327914nc3601_9 · Cited by 226 · see citing works

Growth-inhibitory effects of the astaxanthin-rich alga Haematococcus pluvialis in human colon cancer cells

Palozza, P., Torelli, C., Boninsegna, A., Simone, R. E., Catalano, A., Mele, M. C., & Picci, N. (2009) · Cancer Letters · doi:10.1016/j.canlet.2009.03.031 · Cited by 223 · see citing works

Effects of astaxanthin in obese mice fed a high-fat diet

IKEUCHI, M., KOYAMA, T., TAKAHASHI, J., & YAZAWA, K. (2007) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.60521 · Cited by 222 · see citing works

Treatment of H. pylori infected mice with antioxidant astaxanthin reduces gastric inflammation, bacterial load and modulates cytokine release by splenocytes

Bennedsen, M., Wang, X., Wïllén, R., Wadström, T., & Andersen, L. P. (2000) · Immunology Letters · doi:10.1016/s0165-2478(99)00145-5 · Cited by 216 · see citing works

Characterization of Microalgal Carotenoids by Mass Spectrometry and Their Bioavailability and Antioxidant Properties Elucidated in Rat Model

Ranga Rao, A., Raghunath Reddy, R. L., Baskaran, V., Sarada, R., & Ravishankar, G. A. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101187k · Cited by 215 · see citing works

Astaxanthin protects β-cells against glucose toxicity in diabetic db/db mice

Uchiyama, K., Naito, Y., Hasegawa, G., Nakamura, N., Takahashi, J., & Yoshikawa, T. (2002) · Redox Report · doi:10.1179/135100002125000811 · Cited by 204 · see citing works

Prevention of diabetic nephropathy by treatment with astaxanthin in diabetic db/db mice

Naito, Y., Uchiyama, K., Aoi, W., Hasegawa, G., Nakamura, N., Yoshida, N., Maoka, T., Takahashi, J., & Yoshikawa, T. (2004) · BioFactors · doi:10.1002/biof.5520200105 · Cited by 200 · see citing works

Combined conventional/antioxidant "Astaxanthin" treatment for male infertility: a double blind, randomized trial

Comhaire, F., Garem, Y. F. E., Mahmoud, A., Eertmans, F., & Schoonjans, F. (2005) · Asian Journal of Andrology · doi:10.1111/j.1745-7262.2005.00047.x · Cited by 199 · see citing works

Chemoprevention of mouse urinary bladder carcinogenesis by the naturally occurring carotenoid astaxanthin

Tanaka, T., Morishita, Y., Suzui, M., Kojima, T., Okumura, A., & Mori, H. (1994) · Carcinogenesis · doi:10.1093/carcin/15.1.15 · Cited by 196 · see citing works

Astaxanthin Limits Exercise-Induced Skeletal and Cardiac Muscle Damage in Mice

Aoi, W., Naito, Y., Sakuma, K., Kuchide, M., Tokuda, H., Maoka, T., Toyokuni, S., Oka, S., Yasuhara, M., & Yoshikawa, T. (2003) · Antioxidants and Redox Signaling · doi:10.1089/152308603321223630 · Cited by 195 · see citing works

Antihypertensive and Neuroprotective Effects of Astaxanthin in Experimental Animals

Hussein, G. M. E., Nakamura, M., Zhao, Q., Iguchi, T., Goto, H., Sankawa, U., & Watanabe, H. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.47 · Cited by 191 · see citing works

Protective effects of astaxanthin on 6‐hydroxydopamine‐induced apoptosis in human neuroblastoma SH‐SY5Y cells

Ikeda, Y., Tsuji, S., Satoh, A., Ishikura, M., Shirasawa, T., & Shimizu, T. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05743.x · Cited by 190 · see citing works

Chemoprevention of rat oral carcinogenesis by naturally occurring xanthophylls, astaxanthin and canthaxanthin.

Tanaka, T., Makita, H., Ohnishi, M., Mori, H., Satoh, K., & Hara, A. (1995) · PubMed · Cited by 182 · see citing works

Contribution of the antioxidative property of astaxanthin to its protective effect on the promotion of cancer metastasis in mice treated with restraint stress

Kurihara, H., Kôda, H., Asami, S., Kiso, Y., & Tanaka, T. (2002) · Life Sciences · doi:10.1016/s0024-3205(02)01522-9 · Cited by 180 · see citing works

Astaxanthin improves muscle lipid metabolism in exercise via inhibitory effect of oxidative CPT I modification

Aoi, W., Naito, Y., Takanami, Y., Ishii, T., Kawai, Y., Akagiri, S., Kato, Y., Osawa, T., & Yoshikawa, T. (2007) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2007.12.019 · Cited by 179 · see citing works

Astaxanthin intervention ameliorates cyclophosphamide-induced oxidative stress, DNA damage and early hepatocarcinogenesis in rat: Role of Nrf2, p53, p38 and phase-II enzymes

Tripathi, D. N., & Jena, G. (2009) · Mutation Research/Genetic Toxicology and Environmental Mutagenesis · doi:10.1016/j.mrgentox.2009.12.014 · Cited by 171 · see citing works

Astaxanthin, canthaxanthin and β‐carotene differently affect UVA‐induced oxidative damage and expression of oxidative stress‐responsive enzymes

Camera, E., Mastrofrancesco, A., Fabbri, C., Daubrawa, F., Picardo, M., Sies, H., & Stahl, W. (2008) · Experimental Dermatology · doi:10.1111/j.1600-0625.2008.00790.x · Cited by 170 · see citing works

Ulcer preventive and antioxidative properties of astaxanthin from Haematococcus pluvialis

Kamath, B. S., Srikanta, B. M., Dharmesh, S. M., Sarada, R., & Ravishankar, G. A. (2008) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2008.06.042 · Cited by 162 · see citing works

Suppressive effects of astaxanthin against rat endotoxin-induced uveitis by inhibiting the NF-κB signaling pathway

Suzuki, Y., Ohgami, K., Shiratori, K., Jin, X.-H., Ilieva, I. B., Koyama, Y., Yazawa, K., Yoshida, K., Kase, S., & Ohno, S. (2005) · Experimental Eye Research · doi:10.1016/j.exer.2005.06.023 · Cited by 158 · see citing works

Astaxanthin inhibits reactive oxygen species-mediated cellular toxicity in dopaminergic SH-SY5Y cells via mitochondria-targeted protective mechanism

Liu, X., Shibata, T., Hisaka, S., & Osawa, T. (2008) · Brain Research · doi:10.1016/j.brainres.2008.11.076 · Cited by 158 · see citing works

Characterization of astaxanthin esters in Haematococcus pluvialis by liquid chromatography–atmospheric pressure chemical ionization mass spectrometry

Miao, F., Lu, D., Li, Y., & Zeng, M. (2006) · Analytical Biochemistry · doi:10.1016/j.ab.2006.03.006 · Cited by 154 · see citing works

Astaxanthin attenuates the UVA-induced up-regulation of matrix-metalloproteinase-1 and skin fibroblast elastase in human dermal fibroblasts

Suganuma, K., Nakajima, H., Ohtsuki, M., & Imokawa, G. (2010) · Journal of Dermatological Science · doi:10.1016/j.jdermsci.2010.02.009 · Cited by 154 · see citing works

Biologic Activity of Carotenoids Related to Distinct Membrane Physicochemical Interactions

McNulty, H. P., Jacob, R. F., & Mason, R. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2008.02.004 · Cited by 151 · see citing works

Astaxanthin ameliorates features of metabolic syndrome in SHR/NDmcr-cp

Hussein, G. M. E., Nakagawa, T., Goto, H., Shimada, Y., Matsumoto, K., Sankawa, U., & Watanabe, H. (2006) · Life Sciences · doi:10.1016/j.lfs.2006.09.041 · Cited by 150 · see citing works

Astaxanthin-Rich Algal Meal and Vitamin C Inhibit Helicobacter pylori Infection in BALB/cA Mice

Wang, X., Wïllén, R., & Wadström, T. (2000) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.44.9.2452-2457.2000 · Cited by 149 · see citing works

Antiadult T‐cell leukemia effects of brown algae fucoxanthin and its deacetylated product, fucoxanthinol

Ishikawa, C., Tafuku, S., Kadekaru, T., Sawada, S., Tomita, M., Okudaira, T., Nakazato, T., Toda, T., Uchihara, J., Taira, N., et al. (2008) · International Journal of Cancer · doi:10.1002/ijc.23860 · Cited by 145 · see citing works

Effects of Astaxanthin Supplementation on Exercise-Induced Fatigue in Mice

Ikeuchi, M., Koyama, T., Takahashi, J., & Yazawa, K. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.2106 · Cited by 145 · see citing works

Astaxanthin inhibits cytotoxic and genotoxic effects of cyclophosphamide in mice germ cells

Tripathi, D. N., & Jena, G. (2008) · Toxicology · doi:10.1016/j.tox.2008.03.015 · Cited by 145 · see citing works

Astaxanthin reduces ischemic brain injury in adult rats

Shen, H., Kuo, C.-C., Chou, J., Delvolve, A. M., Jackson, S. N., Post, J. D., Woods, A. S., Hoffer, B. J., Wang, Y., & Harvey, B. K. (2009) · The FASEB Journal · doi:10.1096/fj.08-123281 · Cited by 144 · see citing works

Carotenoid composition in the green microalga Chlorococcum

Yuan, J., Chen, F., Liu, X., & Li, X. (2002) · Food Chemistry · doi:10.1016/s0308-8146(01)00279-5 · Cited by 142 · see citing works

Bioavailability of Non-Provitamin A Carotenoids

Bohn, T. (2008) · Current Nutrition & Food Science · doi:10.2174/157340108786263685 · Cited by 139 · see citing works

Purification of trans-astaxanthin from a high-yielding astaxanthin ester-producing strain of the microalga Haematococcus pluvialis

Yuan, J., & Chen, F. (2000) · Food Chemistry · doi:10.1016/s0308-8146(99)00219-8 · Cited by 137 · see citing works

Modulatory effects of an algal extract containing astaxanthin on UVA-irradiated cells in culture

Lyons, N. M., & O'Brien, N. M. (2002) · Journal of Dermatological Science · doi:10.1016/s0923-1811(02)00063-4 · Cited by 134 · see citing works

Dietary carotenoids inhibit aflatoxin B1-induced liver preneoplastic foci and DNA damage in the rat: role of the modulation of aflatoxin B1 metabolism

Gradelet, S. (1998) · Carcinogenesis · doi:10.1093/carcin/19.3.403 · Cited by 133 · see citing works

Astaxanthin protects mesangial cells from hyperglycemia‐induced oxidative signaling

Manabe, E., Handa, O., Naito, Y., Mizushima, K., Akagiri, S., Adachi, S., Takagi, T., Kokura, S., Maoka, T., & Yoshikawa, T. (2008) · Journal of Cellular Biochemistry · doi:10.1002/jcb.21583 · Cited by 132 · see citing works

Plasma and dietary carotenoid, retinol and tocopherol levels and the risk of gastric adenocarcinomas in the European prospective investigation into cancer and nutrition

Jenab, M., Ríboli, E., Ferrari, P., Friesen, M. D., Sabaté, J., Norat, T., Slimani, N., Tjønneland, A. M., Olsen, A., Overvad, K., et al. (2006) · British Journal of Cancer · doi:10.1038/sj.bjc.6603266 · Cited by 132 · see citing works

Astaxanthin, a dietary carotenoid, protects retinal cells against oxidative stress in-vitro and in mice in-vivo

Nakajima, Y., Inokuchi, Y., Shimazawa, M., Otsubo, K., Ishibashi, T., & Hara, H. (2008) · Journal of Pharmacy and Pharmacology · doi:10.1211/jpp.60.10.0013 · Cited by 127 · see citing works

Effects of astaxanthin on the production of NO and the expression of COX-2 and iNOS in LPS-stimulated BV2 microglial cells.

Choi, S. K., Park, Y. S., Choi, D., & Chang, H. I. (2008) · PubMed · Cited by 127 · see citing works

Antioxidative and anti-inflammatory neuroprotective effects of astaxanthin and canthaxanthin in nerve growth factor differentiated PC12 cells

Chan, K., Mong, M., & Yin, M. (2009) · Journal of Food Science · doi:10.1111/j.1750-3841.2009.01274.x · Cited by 119 · see citing works

Astaxanthin suppresses scavenger receptor expression and matrix metalloproteinase activity in macrophages

Kishimoto, Y., Tani, M., Uto‐Kondo, H., Iizuka, M., Saita, E., Sone, H., Kurata, H., & Kondo, K. (2009) · European Journal of Nutrition · doi:10.1007/s00394-009-0056-4 · Cited by 113 · see citing works

Inhibitory effects of carotenoids on the invasion of rat ascites hepatoma cells in culture

Kozuki, Y., Miura, Y., & Yagasaki, K. (2000) · Cancer Letters · doi:10.1016/s0304-3835(99)00418-8 · Cited by 113 · see citing works

Chromatographic Separation and Purification of trans-Astaxanthin from the Extracts of Haematococcus pluvialis

Yuan, J., & Chen, F. (1998) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf980039b · Cited by 108 · see citing works

Antihypertensive Potential and Mechanism of Action of Astaxanthin: III. Antioxidant and Histopathological Effects in Spontaneously Hypertensive Rats

Hussein, G. M. E., Goto, H., Oda, S., Sankawa, U., Matsumoto, K., & Watanabe, H. (2006) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.29.684 · Cited by 107 · see citing works

Astaxanthin restricts weight gain, promotes insulin sensitivity and curtails fatty liver disease in mice fed a obesity-promoting diet

Bhuvaneswari, S., Elumalai, A., Viswanathan, P., & Anuradha, C. V. (2010) · Process Biochemistry · doi:10.1016/j.procbio.2010.05.016 · Cited by 107 · see citing works

Protection against Oxidative Stress, Inflammation, and Apoptosis of High-Glucose-Exposed Proximal Tubular Epithelial Cells by Astaxanthin

Kim, Y. J., Kim, Y. A., & Yokozawa, T. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9019745 · Cited by 105 · see citing works

Isomerization of trans -Astaxanthin to cis -Isomers in Organic Solvents

Yuan, J., & Chen, F. (1999) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf981319u · Cited by 103 · see citing works

Inhibitory Effect of Carotenoids on the Degranulation of Mast Cells via Suppression of Antigen-induced Aggregation of High Affinity IgE Receptors

Sakai, S., Sugawara, T., Matsubara, K., & Hirata, T. (2009) · Journal of Biological Chemistry · doi:10.1074/jbc.m109.001099 · Cited by 100 · see citing works

Cancer prevention by retinoids and carotenoids: Independent action on a common target

Bertram, J. S., & Vine, A. L. (2005) · Biochimica et Biophysica Acta (BBA) - Molecular Basis of Disease · doi:10.1016/j.bbadis.2005.01.003 · Cited by 99 · see citing works

Inhibition of Choroidal Neovascularization with an Anti-Inflammatory Carotenoid Astaxanthin

Izumi‐Nagai, K., Nagai, N., Ohgami, K., Satofuka, S., Ozawa, Y., Tsubota, K., Ohno, S., Oike, Y., & Ishida, S. (2008) · Investigative Ophthalmology & Visual Science · doi:10.1167/iovs.07-1426 · Cited by 99 · see citing works

Effect of astaxanthin on hepatocellular injury following ischemia/reperfusion

Curek, G. D., Çört, A., Yücel, G., Demır, N., Öztürk, S., Elpek, G. Ö., Savaş, B., & Aslan, M. (2009) · Toxicology · doi:10.1016/j.tox.2009.11.003 · Cited by 94 · see citing works

Astaxanthin addition improves human neutrophils function: in vitro study

Macedo, R. C., Bolin, A. P., Marin, D. P., & Otton, R. (2010) · European Journal of Nutrition · doi:10.1007/s00394-010-0103-1 · Cited by 93 · see citing works

Protective effect of astaxanthin on naproxen-induced gastric antral ulceration in rats

Kim, J., Kim, Y., Song, G. G., Park, J., & Chang, H.-I. (2005) · European Journal of Pharmacology · doi:10.1016/j.ejphar.2005.03.034 · Cited by 93 · see citing works

Effect of astaxanthin on the hepatotoxicity, lipid peroxidation and antioxidative enzymes in the liver of CCl4-treated rats

Kang, J.-O., Kim, S.-J., & Kim, H. (2001) · Methods and Findings in Experimental and Clinical Pharmacology · doi:10.1358/mf.2001.23.2.627931 · Cited by 92 · see citing works

Accumulation of Secondary Carotenoids in Chlorella zofingiensis

Rise, M., Cohen, E., Vishkautsan, M., Cojocaru, M., Gottlieb, H. E., & Arad, S. M. (1994) · Journal of Plant Physiology · doi:10.1016/s0176-1617(11)81189-2 · Cited by 92 · see citing works

Anti- and Prooxidant Properties of Carotenoids

Martin, H., Jager, C. L. D., Ruck, C., Schmidt, M., Walsh, R., & Paust, J. (1999) · Journal für praktische Chemie · doi:10.1002/(sici)1521-3897(199904)341:3 · Cited by 89 · see citing works

Astaxanthin ameliorates the redox imbalance in lymphocytes of experimental diabetic rats

Otton, R., Marin, D. P., Bolin, A. P., dos Santos, R. D. C. M., Polotow, T. G., Sampaio, S. C., & Barros, M. P. (2010) · Chemico-Biological Interactions · doi:10.1016/j.cbi.2010.05.011 · Cited by 88 · see citing works

Efficacy of the natural antioxidant astaxanthin in the treatment of functional dyspepsia in patients with or without Helicobacter pylori infection: A prospective, randomized, double blind, and placebo-controlled study

Kupčinskas, L., Lafolie, P., Lignell, Å., Kiudelis, G., Jonaitis, L. V., Adamonis, K., Andersen, L. P., & Wadström, T. (2008) · Phytomedicine · doi:10.1016/j.phymed.2008.04.004 · Cited by 87 · see citing works

Effects of Astaxanthin on Human Blood Rheology

Miyawaki, H., Takahashi, J., Tsukahara, H., & Takehara, I. (2008) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.2008048 · Cited by 83 · see citing works

Effect of astaxanthin on kidney function impairment and oxidative stress induced by mercuric chloride in rats

Augusti, P. R., Conterato, G. M. M., Somacal, S., Sobieski, R., Spohr, P. R., Torres, J. V., Charão, M. F., Moro, A. M., da Rocha, M. P., García, S. C., et al. (2007) · Food and Chemical Toxicology · doi:10.1016/j.fct.2007.08.001 · Cited by 79 · see citing works

Astaxanthine Secured Apoptotic Death of PC12 Cells Induced by β-Amyloid Peptide 25–35: Its Molecular Action Targets

Chang, C.-H., Chen, C.-Y., Chiou, J.-Y., Peng, R. Y., & Peng, C. (2010) · Journal of Medicinal Food · doi:10.1089/jmf.2009.1291 · Cited by 77 · see citing works

Alpha-tocopherol and astaxanthin decrease macrophage infiltration, apoptosis and vulnerability in atheroma of hyperlipidaemic rabbits

Li, W., Hellsten, A., Jacobsson, L., Blomqvist, H., OLSSON, A. G., & Yuan, X. (2004) · Journal of Molecular and Cellular Cardiology · doi:10.1016/j.yjmcc.2004.07.009 · Cited by 77 · see citing works

Disodium Disuccinate Astaxanthin (Cardax) Attenuates Complement Activation and Reduces Myocardial Injury following Ischemia/Reperfusion

Lauver, A. A., Lockwood, S. F., & Lucchesi, B. R. (2005) · Journal of Pharmacology and Experimental Therapeutics · doi:10.1124/jpet.105.087114 · Cited by 73 · see citing works

Astaxanthin Inhibits H2O2-Mediated Apoptotic Cell Death in Mouse Neural Progenitor Cells via Modulation of P38 and MEK Signaling Pathways

Kim, J. (2009) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.0906.06003 · Cited by 66 · see citing works

Antioxidative and antiproliferative effects of astaxanthin during the initiation stages of 1,2‐dimethyl hydrazine‐induced experimental colon carcinogenesis

Prabhu, P. N., Pandurangan, A. K., & Sudhandiran, G. (2009) · Fundamental and Clinical Pharmacology · doi:10.1111/j.1472-8206.2009.00669.x · Cited by 66 · see citing works

An antioxidant resveratrol significantly enhanced replication of hepatitis C virus

Nakamura, M. (2010) · World Journal of Gastroenterology · doi:10.3748/wjg.v16.i2.184 · Cited by 66 · see citing works

Effect of astaxanthin supplementation on inflammation and cardiac function in BALB/c mice.

Nakao, R., Nelson, O. L., Park, J. S., Mathison, B. D., Thompson, P. A., & Chew, B. P. (2010) · PubMed · Cited by 65 · see citing works

Effect of Astaxanthin in Combination with .ALPHA.-Tocopherol or Ascorbic Acid against Oxidative Damage in Diabetic ODS Rats

Nakano, M. H., ONODERA, A., Saito, E., Tanabe, M., YAJIMA, K., Takahashi, J., & Chuyên, N. V. (2008) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.54.329 · Cited by 64 · see citing works

Astaxanthin prevents in vitro auto-oxidative injury in human lymphocytes

Bolin, A. P., Macedo, R. C., Marin, D. P., Barros, M. P., & Otton, R. (2010) · Cell Biology and Toxicology · doi:10.1007/s10565-010-9156-4 · Cited by 62 · see citing works

Identification of astaxanthin isomers in Haematococcus lacustrisby HPLC-photodiode array detection

Yuan, J., & Chen, F. (1997) · Biotechnology Techniques · doi:10.1023/a:1018441411746 · Cited by 61 · see citing works

Effect of antioxidants on the immune response of Helicobacter pylori

Akyön, Y. (2002) · Clinical Microbiology and Infection · doi:10.1046/j.1469-0691.2002.00426.x · Cited by 59 · see citing works

Chemoprevention by naturally occurring and synthetic agents in oral, liver, and large bowel carcinogenesis

Mori, H., Tanaka, T., Sugie, S., Yoshimi, N., Kawamori, T., Hirose, Y., & Ohnishi, M. (1997) · Journal of Cellular Biochemistry · doi:10.1002/(sici)1097-4644(1997)27+ · Cited by 58 · see citing works

The protective role of carotenoids against 7-keto-cholesterol formation in solution

Palozza, P., Barone, E., Mancuso, C., & Picci, N. (2007) · Molecular and Cellular Biochemistry · doi:10.1007/s11010-007-9643-y · Cited by 56 · see citing works

Cytoprotective role of astaxanthin against glycated protein/iron chelate‐induced toxicity in human umbilical vein endothelial cells

Nishigaki, I., Rajendran, P., Venugopal, R., Ekambaram, G., Sakthisekaran, D., & Nishigaki, Y. (2009) · Phytotherapy Research · doi:10.1002/ptr.2867 · Cited by 54 · see citing works

Suppressive effect of astaxanthin on retinal injury induced by elevated intraocular pressure

Çört, A., Öztürk, N., Akpınar, D., Ünal, M., Yücel, G., Çiftçioğlu, A., Yargıçoğlu, P., & Aslan, M. (2010) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2010.05.001 · Cited by 51 · see citing works

Kinetics for the reversible isomerization reaction of trans-astaxanthin

Yuan, J., & Chen, F. (2001) · Food Chemistry · doi:10.1016/s0308-8146(01)00107-8 · Cited by 50 · see citing works

Esterification of xanthophylls by human intestinal Caco-2 cells

Sugawara, T., Yamashita, K., Asai, A., Nagao, A., Shiraishi, T., Imai, I., & Hirata, T. (2008) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2008.10.007 · Cited by 50 · see citing works

Astaxanthin improves the proliferative capacity as well as the osteogenic and adipogenic differentiation potential in neural stem cells

Kim, J. H., Nam, S., Kim, B. W., Kim, W., & Choi, Y. H. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.04.002 · Cited by 50 · see citing works

Uptake and distribution of astaxanthin in several tissues and plasma lipoproteins in male broiler chickens fed a yeast (Phaffia rhodozyma) with a high concentration of astaxanthin

Takahashi, K., Watanabe, M., Takimoto, T., & Akiba, Y. (2004) · British Poultry Science · doi:10.1080/00071660410001668950a · Cited by 50 · see citing works

Effect of dietary astaxanthin at different stages of mammary tumor initiation in BALB/c mice.

Nakao, R., Nelson, O. L., Park, J. S., Mathison, B. D., Thompson, P. A., & Chew, B. P. (2010) · PubMed · Cited by 50 · see citing works

Erratum to “Amelioration of Streptozotocin-Induced Diabetes by Agrocybe chaxingu Polysaccharide” [Mol. Cells, 29, 349-354, (2010)]

Lee, B. R., Lee, Y. P., Kim, D. W., Song, H. Y., Yoo, K., Won, M. H., Kang, T., Lee, K. J., Kim, K., Joo, J. H., et al. (2013) · Molecules and Cells · doi:10.1007/s10059-013-1044-3 · Cited by 49 · see citing works

Effect of total secondary carotenoids extracts from Chlorococcum sp. on Helicobacter pylori-infected BALB/c mice

Liu, B. H., & Lee, Y. K. (2003) · International Immunopharmacology · doi:10.1016/s1567-5769(03)00096-1 · Cited by 48 · see citing works

Suppressive Effect of Astaxanthin Isolated from theXanthophyllomyces dendrorhousMutant on Ethanol-Induced Gastric Mucosal Injury in Rats

Kim, J., Choi, S.-K., Choi, S.-Y., Kim, H. K., & Chang, H.-I. (2005) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.69.1300 · Cited by 47 · see citing works

Summative interaction between astaxanthin,Ginkgo bilobaextract (EGb761) and vitamin C in Suppression of respiratory inflammation: a comparison with ibuprofen

Haines, D. D., Varga, B., Bak, I., Juhász, B., Mahmoud, F. F., Kalantari‬, H., Gesztelyi, R., Lekli, I., Czompa, A., & Tósaki, Á. (2010) · Phytotherapy Research · doi:10.1002/ptr.3160 · Cited by 47 · see citing works

Antihypertensive Potential and Mechanism of Action of Astaxanthin: II. Vascular Reactivity and Hemorheology in Spontaneously Hypertensive Rats

Hussein, G. M. E., Goto, H., Oda, S., Iguchi, T., Sankawa, U., Matsumoto, K., & Watanabe, H. (2005) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.28.967 · Cited by 47 · see citing works

Astaxanthin Protects against Oxidative Stress and Calcium-Induced Porcine Lens Protein Degradation

Wu, T., Liao, J., Hou, W., Huang, F.-Y., Maher, T. J., & Hu, C.-C. (2006) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf052651q · Cited by 46 · see citing works

In vivo astaxanthin treatment partially prevents antioxidant alterations in dental pulp from alloxan‐induced diabetic rats

Leite, M. F., de Lima, A., Massuyama, M. M., & Otton, R. (2010) · International Endodontic Journal · doi:10.1111/j.1365-2591.2010.01707.x · Cited by 45 · see citing works

Comparative analysis of astaxanthin and its esters in the mutant E1 of Haematococcus pluvialis and other green algae by HPLC with a C30 column

Peng, J., Xiang, W., Tang, Q., Sun, N., Chen, F., & Yuan, J. (2008) · Science in China Series C Life Sciences · doi:10.1007/s11427-008-0146-1 · Cited by 44 · see citing works

Astaxanthin Diminishes Gap Junctional Intercellular Communication in Primary Human Fibroblasts

Daubrawa, F., Sies, H., & Stahl, W. (2005) · Journal of Nutrition · doi:10.1093/jn/135.11.2507 · Cited by 40 · see citing works

Effects of Astaxanthin and Vitamin C on the Prevention of Gastric Ulcerations in Stressed Rats

NISHIKAWA, Y., MINENAKA, Y., ICHIMURA, M., Tatsumi, K., Nadamoto, T., & Urabe, K. (2005) · Journal of Nutritional Science and Vitaminology · doi:10.3177/jnsv.51.135 · Cited by 37 · see citing works

Astaxanthin Inhibits Glutamate Release in Rat Cerebral Cortex Nerve Terminals via Suppression of Voltage-Dependent Ca2+Entry and Mitogen-Activated Protein Kinase Signaling Pathway

Lin, T., Lü, C.-W., & Wang, S. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf101689t · Cited by 36 · see citing works

Dose‐Dependent Effects of Astaxanthin on Cortical Spreading Depression in Chronically Ethanol‐Treated Adult Rats

Abadie‐Guedes, R., Santos, S. D., Cahú, T. B., Guedes, R. C. A., & Bezerra, R. D. S. (2008) · Alcoholism Clinical and Experimental Research · doi:10.1111/j.1530-0277.2008.00710.x · Cited by 36 · see citing works

Astaxanthin lowers blood pressure and lessens the activity of the renin-angiotensin system in Zucker Fatty Rats

Preuss, H. G., Echard, B. W., Bagchi, D., Perricone, N. V., & Yamashita, E. (2008) · Journal of Functional Foods · doi:10.1016/j.jff.2008.09.001 · Cited by 34 · see citing works

In Vitro Effects of Astaxanthin Combined With Ginkgolide B on T Lymphocyte Activation in Peripheral Blood Mononuclear Cells From Asthmatic Subjects

Mahmoud, F. F., Haines, D. D., Abul, H. T., Abal, A. T., Onadeko, B. O., & Wise, J. A. (2004) · Journal of Pharmacological Sciences · doi:10.1254/jphs.94.129 · Cited by 27 · see citing works

Sports Performance Benefits from Taking Natural Astaxanthin Characterized by Visual Acuity and Muscle Fatigue Improvement in Humans.

Sawaki, K., Yoshigi, H., Kazuhiro, A., Koikawa, N., Akito, A., Kesatoki, K., & Masahiro, Y. (2002) · 臨床医薬 · Cited by 26 · see citing works

Microarray profiling of gene expression patterns in glomerular cells of astaxanthin-treated diabetic mice: A nutrigenomic approach

Naito, Y., Uchiyama, K., Mizushima, K., Kuroda, M., Akagiri, S., Takagi, T., Handa, O., Kokura, S., Yoshida, N., Ichikawa, H., et al. (2006) · International Journal of Molecular Medicine · doi:10.3892/ijmm.18.4.685 · Cited by 24 · see citing works

Astaxanthin restores the enzymatic antioxidant profile in salivary gland of alloxan-induced diabetic rats

Leite, M. F., de Lima, A. M., Massuyama, M. M., & Otton, R. (2010) · Archives of Oral Biology · doi:10.1016/j.archoralbio.2010.04.006 · Cited by 23 · see citing works

The Effect of Astaxanthin on Retinal Capillary Blood Flow in Normal Volunteers

Nagaki, Y., Mihara, M., Jiro, T., Kitamura, A., Horita, Y., Yuri, S., & Tsukahara, H. (2005) · 臨床医薬 · Cited by 23 · see citing works

Astaxanthin Reduces Oxidative Stress, but not Aortic Damage in Atherosclerotic Rabbits

Augusti, P. R., Conterato, G. M. M., Somacal, S., Sobieski, R., Quatrin, A., Maurer, L. H., da Rocha, M. P., Denardin, I. T., & Emanuelli, T. (2009) · Journal of Cardiovascular Pharmacology and Therapeutics · doi:10.1177/1074248409350136 · Cited by 22 · see citing works

The supplementation effect of Astaxanthin on Accommodation and Asthenopia

Nagaki, Y., Mihara, M., Tsukahara, H., & Ono, S. (2006) · 臨床医薬 · Cited by 22 · see citing works

Induction of connexin 43 by carotenoids: functional consequences

Bertram, J. S. (2004) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2004.02.037 · Cited by 20 · see citing works

Effect of carotenoids on in vitro proliferation and differentiation of oval cells during neoplastic and non-neoplastic liver injuries in rats.

Wójcik, M., BOBOWIEC, R., & Martelli, F. (2008) · PubMed · Cited by 17 · see citing works

Weight Gain Limitation and Liver Protection by Long-Term Feeding of Astaxanthin in Murines

Kim, H. B. (2009) · Journal of the Korean Society for Applied Biological Chemistry · doi:10.3839/jksabc.2009.033 · Cited by 17 · see citing works

Visualization of astaxanthin localization in HT29 human colon adenocarcinoma cells by combined confocal resonance Raman and fluorescence microspectroscopy

Briviba, K., Bornemann, R., & Lemmer, U. (2006) · Molecular Nutrition & Food Research · doi:10.1002/mnfr.200600056 · Cited by 17 · see citing works

Astaxanthin Interacts with Selenite and Attenuates Selenite-Induced Cataractogenesis

Liao, J., Chen, C., Maher, T. J., Liu, C.-Y., Lin, M.-H., Wu, T., & Wu, S. (2009) · Chemical Research in Toxicology · doi:10.1021/tx800378z · Cited by 16 · see citing works

Reduction of oxidized guanosine by dietary carotenoids: A pulse radiolysis study

Edge, R., Gaikwad, P., Navaratnam, S., Rao, B. S. M., & Truscott, T. G. (2010) · Archives of Biochemistry and Biophysics · doi:10.1016/j.abb.2010.07.026 · Cited by 14 · see citing works

Protective effect of astaxanthin produced by Xanthophyllomyces dendrorhous mutant on indomethacin-induced gastric mucosal injury in rats

Kim, J. H., Choi, S. K., Lim, W. J., & Chang, H. I. (2004) · Journal of Microbiology and Biotechnology · Cited by 12 · see citing works

Fiber Type-Specific Responses to Perceptions of Delayed Onset Muscle Soreness with Astaxanthin Supplementation

Fry, A. C., Schilling, B. K., Chiu, L. Z. F., Hori, N., & Weiss, L. W. (2004) · Medicine & Science in Sports & Exercise · doi:10.1097/00005768-200405001-00839 · Cited by 5 · see citing works

Fiber Type-Specific Responses to Perceptions of Delayed Onset Muscle Soreness with Astaxanthin Supplementation

Fry, A. C., Schilling, B. K., Chiu, L. Z. F., et al. (2004) · Medicine & Science in Sports & Exercise · doi:10.1249/00005768-200405001-00839 · Cited by 5 · see citing works

Astaxanthin: Sources, Extraction, Stability, Biological Activities and Its Commercial Applications—A Review

Ambati, R., Phang, S. M., Ravi, S., & Ravishankar, G. A. (2014) · Marine Drugs · doi:10.3390/md12010128 · Cited by 1,993 · see citing works

Astaxanthin-Producing Green Microalga Haematococcus pluvialis: From Single Cell to High Value Commercial Products

Shah, M. M. R., Liang, Y., Cheng, J. J., & Daroch, M. (2016) · Frontiers in Plant Science · doi:10.3389/fpls.2016.00531 · Cited by 940 · see citing works

Microalgae Metabolites: A Rich Source for Food and Medicine

Sathasivam, R., Radhakrishnan, R., Hashem, A., & Abd_Allah, E. F. (2019) · Saudi Journal of Biological Sciences · doi:10.1016/j.sjbs.2017.11.003 · Cited by 872 · see citing works

Microalgae for High-Value Compounds and Biofuels Production: A Review with Focus on Cultivation under Stress Conditions

Markou, G., & Nerantzis, E. (2013) · Biotechnology Advances · doi:10.1016/j.biotechadv.2013.07.011 · Cited by 815 · see citing works

Carotenoids from fruits and vegetables: Chemistry, analysis, occurrence, bioavailability and biological activities

Saini, R. K., Nile, S. H., & Park, S. W. (2015) · Food Research International · doi:10.1016/j.foodres.2015.07.047 · Cited by 758 · see citing works

Marine Bioactives as Functional Food Ingredients: Potential to Reduce the Incidence of Chronic Diseases

Lordan, S., Ross, R. P., & Stanton, C. (2011) · Marine Drugs · doi:10.3390/md9061056 · Cited by 754 · see citing works

New horizons in the extraction of bioactive compounds using deep eutectic solvents: A review

Zainal-Abidin, M. H., Hayyan, M., Hayyan, A., & Jayakumar, N. S. (2017) · Analytica Chimica Acta · doi:10.1016/j.aca.2017.05.012 · Cited by 643 · see citing works

Cancer Chemoprevention by Carotenoids

Tanaka, T., Shnimizu, M., & Moriwaki, H. (2012) · Molecules · doi:10.3390/molecules17033202 · Cited by 590 · see citing works

Extraction and purification of high‐value metabolites from microalgae: essential lipids, astaxanthin and phycobiliproteins

Cuellar‐Bermudez, S. P., Aguilar‐Hernandez, I., Cardenas‐Chavez, D. L., Ornelas‐Soto, N., Romero‐Ogawa, M. A., & Parra‐Saldivar, R. (2015) · Microbial Biotechnology · doi:10.1111/1751-7915.12167 · Cited by 486 · see citing works

Astaxanthin in Skin Health, Repair, and Disease: A Comprehensive Review

Davinelli, S., Nielsen, M. E., & Scapagnini, G. (2018) · Nutrients · doi:10.3390/nu10040522 · Cited by 473 · see citing works

Microalgae for the production of lipid and carotenoids: a review with focus on stress regulation and adaptation

Sun, X.-M., Ren, L.-J., Zhao, Q.-Y., Ji, X.-J., & Huang, H. (2018) · Biotechnology for Biofuels · doi:10.1186/s13068-018-1275-9 · Cited by 470 · see citing works

Astaxanthin: A mechanistic review on its biological activities and health benefits

Fakhri, S., Abbaszadeh, F., Dargahi, L., & Jorjani, M. (2018) · Pharmacological Research · doi:10.1016/j.phrs.2018.08.012 · Cited by 465 · see citing works

An overview: biomolecules from microalgae for animal feed and aquaculture

Yaakob, Z., Ali, E., Zainal, A., Mohamad, M., & Takriff, M. S. (2014) · Journal of Biological Research - Thessaloniki · doi:10.1186/2241-5793-21-6 · Cited by 464 · see citing works

A Review on the Assessment of Stress Conditions for Simultaneous Production of Microalgal Lipids and Carotenoids

Minhas, A. K., Hodgson, P., Barrow, C. J., & Adholeya, A. (2016) · Frontiers in Microbiology · doi:10.3389/fmicb.2016.00546 · Cited by 451 · see citing works

Astaxanthin as feed supplement in aquatic animals

Lim, K. C., Yusoff, F. M., Shariff, M., & Kamarudin, M. S. (2017) · Reviews in Aquaculture · doi:10.1111/raq.12200 · Cited by 449 · see citing works

Mediterranean diet: The role of long-chain ω-3 fatty acids in fish; polyphenols in fruits, vegetables, cereals, coffee, tea, cacao and wine; probiotics and vitamins in prevention of stroke, age-related cognitive decline, and Alzheimer disease

Román, G. C., Jackson, R. E., Gadhia, R. R., Roman, A., & Reis, J. J. (2019) · Revue Neurologique · doi:10.1016/j.neurol.2019.08.005 · Cited by 422 · see citing works

Microalgae as Healthy Ingredients for Functional Food: A Review

Matos, J., Cardoso, C., Bandarra, N. M., & Afonso, C. (2017) · Food & Function · doi:10.1039/c7fo00409e · Cited by 394 · see citing works

Carotenoids: potential allies of cardiovascular health?

Gammone, M. A., Riccioni, G., & D’Orazio, N. (2015) · Food & Nutrition Research · doi:10.3402/fnr.v59.26762 · Cited by 326 · see citing works

Recent advances in biorefinery of astaxanthin from Haematococcus pluvialis

Khoo, K. S., Lee, S. Y., Ooi, C. W., Fu, X., Miao, X., Ling, T. C., & Show, P. L. (2019) · Bioresource Technology · doi:10.1016/j.biortech.2019.121606 · Cited by 318 · see citing works

Biological roles of fungal carotenoids

Ávalos, J., & Limón, M. C. (2014) · Current Genetics · doi:10.1007/s00294-014-0454-x · Cited by 308 · see citing works

Effect of microalgal biomass incorporation into foods: Nutritional and sensorial attributes of the end products

Lafarga, T. (2019) · Algal Research · doi:10.1016/j.algal.2019.101566 · Cited by 296 · see citing works

Dietary Intake of Carotenoids and Their Antioxidant and Anti-Inflammatory Effects in Cardiovascular Care

Ciccone, M. M., Cortese, F., Gesualdo, M., Carbonara, S., Zito, A., Ricci, G., Pascalis, F. D., Scicchitano, P., & Riccioni, G. (2013) · Mediators of Inflammation · doi:10.1155/2013/782137 · Cited by 292 · see citing works

Inhibitory Effect of Astaxanthin on Oxidative Stress-Induced Mitochondrial Dysfunction-A Mini-Review

Kim, S. H., & Kim, H. (2018) · Nutrients · doi:10.3390/nu10091137 · Cited by 291 · see citing works

The Evolution and Versatility of Microalgal Biotechnology: A Review

Hamed, I. (2016) · Comprehensive Reviews in Food Science and Food Safety · doi:10.1111/1541-4337.12227 · Cited by 289 · see citing works

The Potential of Microalgae for the Production of Bioactive Molecules of Pharmaceutical Interest

Mimouni, V., Ulmann, L., Pasquet, V., Mathieu, M., Picot, L., Bougaran, G., Cadoret, J., Morant-Manceau, A., & Schoefs, B. (2012) · Current Pharmaceutical Biotechnology · doi:10.2174/138920112804724828 · Cited by 274 · see citing works

Marine Carotenoids against Oxidative Stress: Effects on Human Health

Gammone, M. A., Riccioni, G., & D’Orazio, N. (2015) · Marine Drugs · doi:10.3390/md13106226 · Cited by 274 · see citing works

Astaxanthin and its Effects in Inflammatory Responses and Inflammation-Associated Diseases: Recent Advances and Future Directions

Chang, M. X., & Xiong, F. (2020) · Molecules · doi:10.3390/molecules25225342 · Cited by 273 · see citing works

Astaxanthin, cell membrane nutrient with diverse clinical benefits and anti-aging potential.

Kidd, P. M. (2011) · PubMed · Cited by 264 · see citing works

Health benefits of carotenoids and potential application in poultry industry: A review

Nabi, F., Arain, M. A., Rajput, N. A., Alagawany, M. M., Soomro, J., Umer, M., Soomro, F., Wang, Z., Ye, R., & Liu, J. (2020) · Journal of Animal Physiology and Animal Nutrition · doi:10.1111/jpn.13375 · Cited by 263 · see citing works

Bioactive Compounds Isolated from Microalgae in Chronic Inflammation and Cancer

Talero, E., García‐Mauriño, S., Ávila‐Román, J., Rodríguez-Luna, A., Alcaide, A. M., & Motilva, V. (2015) · Marine Drugs · doi:10.3390/md13106152 · Cited by 258 · see citing works

Cosmetic benefits of astaxanthin on humans subjects.

Tominaga, K., Hongo, N., Karato, M., & Yamashita, E. (2012) · Acta Biochimica Polonica · doi:10.18388/abp.2012_2168 · Cited by 248 · see citing works

Astaxanthin: A super antioxidant from microalgae and its therapeutic potential

Kumar, S., Kumar, R., Diksha, Kumari, A., & Panwar, A. (2021) · Journal of Basic Microbiology · doi:10.1002/jobm.202100391 · Cited by 247 · see citing works

Discovering the link between nutrition and skin aging

Schagen, S., Zampeli, V., Makrantonaki, E., & Zouboulis, C. C. (2012) · Dermato-Endocrinology · doi:10.4161/derm.22876 · Cited by 246 · see citing works

Functional ingredients from microalgae

Buono, S., Langellotti, A. L., Martello, A., Rinna, F., & Fogliano, V. (2014) · Food & Function · doi:10.1039/c4fo00125g · Cited by 241 · see citing works

Skin Carotenoids in Public Health and Nutricosmetics: The Emerging Roles and Applications of the UV Radiation-Absorbing Colourless Carotenoids Phytoene and Phytofluene

Meléndez‐Martínez, A. J., Stinco, C. M., & Mapelli‐Brahm, P. (2019) · Nutrients · doi:10.3390/nu11051093 · Cited by 234 · see citing works

Cheese Whey Processing: Integrated Biorefinery Concepts and Emerging Food Applications

Lappa, I. K., Papadaki, A., Kachrimanidou, V., Τέρπου, Α., Koulougliotis, D., Eriotou, E., & Kopsahelis, N. (2019) · Foods · doi:10.3390/foods8080347 · Cited by 230 · see citing works

On the Neuroprotective Role of Astaxanthin: New Perspectives?

Galasso, C., Orefice, I., Pellone, P., Cirino, P., Miele, R., Ianora, A., Brunet, C., & Sansone, C. (2018) · Marine Drugs · doi:10.3390/md16080247 · Cited by 228 · see citing works

Potential Anti-Atherosclerotic Properties of Astaxanthin

Kishimoto, Y., Yoshida, H., & Kondo, K. N. (2016) · Marine Drugs · doi:10.3390/md14020035 · Cited by 222 · see citing works

Biotechnological production of astaxanthin from the microalga Haematococcus pluvialis

Li, X., Wang, X., Duan, C., Yi, S., Gao, Z., Xiao, C., Agathos, S. N., Wang, G., & Li, J. (2020) · Biotechnology Advances · doi:10.1016/j.biotechadv.2020.107602 · Cited by 221 · see citing works

Astaxanthin: A Potential Mitochondrial-Targeted Antioxidant Treatment in Diseases and with Aging

Sztretye, M. T., Dienes, B., Gönczi, M., Czirják, T., Csernoch, L. J., László, A., Szentesi, P., & Keller-Pintér, A. (2019) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2019/3849692 · Cited by 218 · see citing works

Astaxanthin inhibits NF-κB and Wnt/β-catenin signaling pathways via inactivation of Erk/MAPK and PI3K/Akt to induce intrinsic apoptosis in a hamster model of oral cancer

Kavitha, K. J., Kowshik, J., Tanagala, K. K. K., Baba, A. B., & Nagini, S. (2013) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2013.05.032 · Cited by 212 · see citing works

Omega-3 biotechnology: Thraustochytrids as a novel source of omega-3 oils

Gupta, A., Barrow, C. J., & Puri, M. (2012) · Biotechnology Advances · doi:10.1016/j.biotechadv.2012.02.014 · Cited by 210 · see citing works

Microalgae Encapsulation Systems for Food, Pharmaceutical and Cosmetics Applications

Vieira, M. V., Pastrana, L. M., & Fuciños, P. (2020) · Marine Drugs · doi:10.3390/md18120644 · Cited by 205 · see citing works

Microalgal carotenoids: beneficial effects and potential in human health

Zhang, J., Sun, Z., Sun, P., Chen, T., & Chen, F. (2013) · Food & Function · doi:10.1039/c3fo60607d · Cited by 205 · see citing works

Docosahexaenoic acid (DHA), a fundamental fatty acid for the brain: New dietary sources

Echeverría, F., Valenzuela, R., Hernández‐Rodas, M. C., & Valenzuela, A. (2017) · Prostaglandins Leukotrienes and Essential Fatty Acids · doi:10.1016/j.plefa.2017.08.001 · Cited by 205 · see citing works

Astaxanthin as a Potential Neuroprotective Agent for Neurological Diseases

Wu, H., Niu, H., Shao, A., Wu, C., Dixon, B. J., Zhang, J., Yang, S., & Wang, Y. (2015) · Marine Drugs · doi:10.3390/md13095750 · Cited by 204 · see citing works

Marine Microbial-Derived Molecules and Their Potential Use in Cosmeceutical and Cosmetic Products

Corinaldesi, C., Barone, G., Marcellini, F., Dell’Anno, A., & Danovaro, R. (2017) · Marine Drugs · doi:10.3390/md15040118 · Cited by 201 · see citing works

Neuroprotective mechanisms of astaxanthin: a potential therapeutic role in preserving cognitive function in age and neurodegeneration

Grimmig, B. A., Kim, S.-H., Nash, K. R., Bickford, P. C., & Shytle, R. D. (2017) · GeroScience · doi:10.1007/s11357-017-9958-x · Cited by 200 · see citing works

Biotechnology of non-Saccharomyces yeasts—the ascomycetes

Johnson, E. A. (2013) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-012-4497-y · Cited by 193 · see citing works

Metabolic engineering of Escherichia coli for high-level astaxanthin production with high productivity

Park, S. Y., Binkley, R. M., Kim, W. J., Lee, M. H., & Lee, S. Y. (2018) · Metabolic Engineering · doi:10.1016/j.ymben.2018.08.002 · Cited by 182 · see citing works

Turning a green alga red: engineering astaxanthin biosynthesis by intragenic pseudogene revival in Chlamydomonas reinhardtii

Perozeni, F., Cazzaniga, S., Baier, T., Zanoni, F., Zoccatelli, G., Lauersen, K. J., Wobbe, L., & Ballottari, M. (2020) · Plant Biotechnology Journal · doi:10.1111/pbi.13364 · Cited by 181 · see citing works

Chromosome-level genome assembly and transcriptome of the green alga Chromochloris zofingiensis illuminates astaxanthin production

Roth, M., Cokus, S. J., Gallaher, S. D., Walter, A., Lopez, D., Erickson, E., Endelman, B., Westcott, D. J., Larabell, C. A., Merchant, S., et al. (2017) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.1619928114 · Cited by 179 · see citing works

Absorption and Metabolism of Xanthophylls

Kotake‐Nara, E., & Nagao, A. (2011) · Marine Drugs · doi:10.3390/md9061024 · Cited by 175 · see citing works

Biotechnological Applications of Microalgae

Chu, W.-L. (2012) · International e-Journal of Science, Medicine & Education · doi:10.56026/imu.6.suppl1.s24 · Cited by 174 · see citing works

Astaxanthin extraction from Haematococcus pluvialis using CO2-expanded ethanol

Reyes, F. A., Mendiola, J. A., Ibáñez, E., & del Valle, J. M. (2014) · The Journal of Supercritical Fluids · doi:10.1016/j.supflu.2014.05.013 · Cited by 166 · see citing works

Industrial and Biotechnological Applications of Algae: A Review

Sharma, P., & Sharma, N. (2017) · Journal of Advances in Plant Biology · doi:10.14302/issn.2638-4469.japb-17-1534 · Cited by 166 · see citing works

Recent progress in practical applications of a potential carotenoid astaxanthin in aquaculture industry: a review

Elbahnaswy, S., & Elshopakey, G. E. (2023) · Fish Physiology and Biochemistry · doi:10.1007/s10695-022-01167-0 · Cited by 166 · see citing works

Heterotrophic cultivation of microalgae: production of metabolites of commercial interest

Morales‐Sánchez, D., Martinez-Rodriguez, O. A., & Martı́nez, A. (2016) · Journal of Chemical Technology & Biotechnology · doi:10.1002/jctb.5115 · Cited by 164 · see citing works

Metabolic engineering of tomato for high-yield production of astaxanthin

Huang, J., Zhong, Y., Liu, J., Sandmann, G., & Chen, F. (2013) · Metabolic Engineering · doi:10.1016/j.ymben.2013.02.005 · Cited by 162 · see citing works

Astaxanthin and omega-3 fatty acids individually and in combination protect against oxidative stress via the Nrf2–ARE pathway

Saw, C. L. L., Yang, Y., Guo, Y., & Kong, A. T. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2013.10.023 · Cited by 155 · see citing works

Marine Bioactives: Pharmacological Properties and Potential Applications against Inflammatory Diseases

D’Orazio, N., Gammone, M. A., Gemello, E., Girolamo, M. D., Cusenza, S., & Riccioni, G. (2012) · Marine Drugs · doi:10.3390/md10040812 · Cited by 154 · see citing works

Highly efficient biosynthesis of astaxanthin in Saccharomyces cerevisiae by integration and tuning of algal crtZ and bkt

Zhou, P., Ye, L., Xie, W., Lv, X., & Yu, H. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6791-y · Cited by 149 · see citing works

Recent breakthroughs in the biology of astaxanthin accumulation by microalgal cell

Solovchenko, A. E. (2015) · Photosynthesis Research · doi:10.1007/s11120-015-0156-3 · Cited by 147 · see citing works

Characterization and classification of highly productive microalgae strains discovered for biofuel and bioproduct generation

Neofotis, P. G., Huang, A., Sury, K., Chang, W., Joseph, F., Gabr, A., Twary, S. N., Qiu, W., Holguin, O., & Polle, J. E. W. (2016) · Algal Research · doi:10.1016/j.algal.2016.01.007 · Cited by 146 · see citing works

Functional foods and their role in cancer prevention and health promotion: a comprehensive review.

Aghajanpour, M., Nazer, M. R., Obeidavi, Z., Akbari, M., Ezati, P., & Kor, N. M. (2017) · PubMed Central · Cited by 145 · see citing works

Microalgae Derived Astaxanthin: Research and Consumer Trends and Industrial Use as Food

Villaró, S., Ciardi, M., Morillas‐España, A., Sánchez‐Zurano, A., Acién, F. G., & Lafarga, T. (2021) · Foods · doi:10.3390/foods10102303 · Cited by 144 · see citing works

Nutraceuticals From Algae and Cyanobacteria

Udayan, A., Arumugam, M., & Pandey, A. (2017) · Algal Green Chemistry · doi:10.1016/b978-0-444-63784-0.00004-7 · Cited by 143 · see citing works

Astaxanthin Treatment Reduced Oxidative Induced Pro-Inflammatory Cytokines Secretion in U937: SHP-1 as a Novel Biological Target

Speranza, L., Pesce, M., Patruno, A., Franceschelli, S., Lutiis, M. A. D., Grilli, A., & Felaco, M. (2012) · Marine Drugs · doi:10.3390/md10040890 · Cited by 143 · see citing works

Astaxanthin Prevents Alcoholic Fatty Liver Disease by Modulating Mouse Gut Microbiota

Liu, H., Liu, M., Fu, X., Zhang, Z., Zhu, L., Zheng, X., & Liu, J. (2018) · Nutrients · doi:10.3390/nu10091298 · Cited by 137 · see citing works

Biological and neurological activities of astaxanthin (Review)

Si, P., & Zhu, C. (2022) · Molecular Medicine Reports · doi:10.3892/mmr.2022.12816 · Cited by 137 · see citing works

Edible Microalgae and Their Bioactive Compounds in the Prevention and Treatment of Metabolic Alterations

Ramos-Romero, S., Torrella, J. R., Pagès, T., Viscor, G., & Torres, J. L. (2021) · Nutrients · doi:10.3390/nu13020563 · Cited by 134 · see citing works

Encapsulation of an astaxanthin-containing lipid extract from shrimp waste by complex coacervation using a novel gelatin–cashew gum complex

Gómez‐Estaca, J., Comunian, T. A., Montero, P., Furtado, R. F., & Fávaro-Trindade, C. S. (2016) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2016.05.005 · Cited by 134 · see citing works

Antioxidants in Sport Nutrition

Lamprecht, M. (2014) · CRC Press eBooks · doi:10.1201/b17442 · Cited by 133 · see citing works

Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome

Vollmer, D. L., West, V. A., & Lephart, E. D. (2018) · International Journal of Molecular Sciences · doi:10.3390/ijms19103059 · Cited by 132 · see citing works

Novel Insights into the Biotechnological Production of Haematococcus pluvialis-Derived Astaxanthin: Advances and Key Challenges to Allow Its Industrial Use as Novel Food Ingredient

Jannel, S., Caro, Y., Bermudes, M., & Petit, T. (2020) · Journal of Marine Science and Engineering · doi:10.3390/jmse8100789 · Cited by 132 · see citing works

Astaxanthin Attenuates the Apoptosis of Retinal Ganglion Cells in db/db Mice by Inhibition of Oxidative Stress

Dong, L.-Y., Jin, J., Gao, L., & Kang, X. (2013) · Marine Drugs · doi:10.3390/md11030960 · Cited by 131 · see citing works

Mitochondrial dysfunction and skeletal muscle atrophy: Causes, mechanisms, and treatment strategies

Kubat, G. B., Bouhamida, E., Ülger, Ö., Türkel, İ., Pedriali, G., Ramaccini, D., Ekinci, Ö., Özerkliğ, B., Atalay, Ö., Patergnani, S., et al. (2023) · Mitochondrion · doi:10.1016/j.mito.2023.07.003 · Cited by 128 · see citing works

Photosynthetic response to nitrogen starvation and high light in Haematococcus pluvialis

Scibilia, L., Girolomoni, L., Berteotti, S., Alboresi, A., & Ballottari, M. (2015) · Algal Research · doi:10.1016/j.algal.2015.08.024 · Cited by 127 · see citing works

In vivo bioavailability and antioxidant activity of carotenoids from microalgal biomass — A repeated dose study

Rao, A. R., Baskaran, V., Sarada, R., & Ravishankar, G. A. (2013) · Food Research International · doi:10.1016/j.foodres.2013.07.067 · Cited by 127 · see citing works

Astaxanthin as a King of Ketocarotenoids: Structure, Synthesis, Accumulation, Bioavailability and Antioxidant Properties

Nair, A., Ahirwar, A., Singh, S., Lodhi, R., Lodhi, A., Rai, A., Jadhav, D. A., Mangesh, H., Varjani, S., Singh, G., et al. (2023) · Marine Drugs · doi:10.3390/md21030176 · Cited by 127 · see citing works

Clinical Applications of Astaxanthin in the Treatment of Ocular Diseases: Emerging Insights

Giannaccare, G., Pellegrini, M., Senni, C., Bernabei, F., Scorcia, V., & Cicero, A. F. G. (2020) · Marine Drugs · doi:10.3390/md18050239 · Cited by 125 · see citing works

Microalgal carotenoids and phytosterols regulate biochemical mechanisms involved in human health and disease prevention

Le Goff, M., Le Ferrec, E., Mayer, C., Mimouni, V., Lagadic-Gossmann, D., Schoefs, B., & Ulmann, L. (2019) · Biochimie · doi:10.1016/j.biochi.2019.09.012 · Cited by 123 · see citing works

Marine natural pigments as potential sources for therapeutic applications

Manivasagan, P., Bharathiraja, S., Santhamoorthy, M., Mondal, S., Seo, H., Lee, K. D., & Oh, J. (2017) · Critical Reviews in Biotechnology · doi:10.1080/07388551.2017.1398713 · Cited by 122 · see citing works

Bioactivities of astaxanthin from natural sources, augmenting its biomedical potential: A review

Aneesh, P. A., Ajeeshkumar, K. K., Lekshmi, R. G. K., Anandan, R., Ravishankar, C. N., & Mathew, S. (2022) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2022.05.004 · Cited by 120 · see citing works

Plastids of Marine Phytoplankton Produce Bioactive Pigments and Lipids

Heydarizadeh, P., Poirier, I., Loizeau, D., Ulmann, L., Mimouni, V., Schoefs, B., & Bertrand, M. (2013) · Marine Drugs · doi:10.3390/md11093425 · Cited by 117 · see citing works

Anti-Inflammatory Effects of Different Astaxanthin Isomers and the Roles of Lipid Transporters in the Cellular Transport of Astaxanthin Isomers in Caco-2 Cell Monolayers

Yang, C., Hassan, Y. I., Liu, R., Zhang, H., Chen, Y., Zhang, L., & Tsao, R. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.9b02102 · Cited by 116 · see citing works

Carotenoid supplementation and retinoic acid in immunoglobulin A regulation of the gut microbiota dysbiosis

Lyu, Y., Wu, L., Wang, F., Shen, X., & Lin, D. (2018) · Experimental Biology and Medicine · doi:10.1177/1535370218763760 · Cited by 114 · see citing works

Characteristics and bioactive functions of chitosan/gelatin-based film incorporated with ε-polylysine and astaxanthin extracts derived from by-products of shrimp (Litopenaeus vannamei)

Xu, J., Wei, R., Jia, Z., & Song, R. (2019) · Food Hydrocolloids · doi:10.1016/j.foodhyd.2019.105436 · Cited by 112 · see citing works

Astaxanthin attenuates total body irradiation-induced hematopoietic system injury in mice via inhibition of oxidative stress and apoptosis

Xue, X.-L., Han, X., Li, Y., Chu, X., Miao, W., Zhang, J., & Fan, S. (2017) · Stem Cell Research & Therapy · doi:10.1186/s13287-016-0464-3 · Cited by 110 · see citing works

The importance of the cellular stress response in the pathogenesis and treatment of type 2 diabetes

Hooper, P. L., Balogh, G. E., Rivas, E., Kavanagh, K., & Vı́gh, L. (2014) · Cell Stress and Chaperones · doi:10.1007/s12192-014-0493-8 · Cited by 109 · see citing works

Therapeutic potential of astaxanthin and superoxide dismutase in Alzheimer's disease

Balendra, V., & Singh, S. K. (2021) · Open Biology · doi:10.1098/rsob.210013 · Cited by 108 · see citing works

Astaxanthin Attenuates Early Acute Kidney Injury Following Severe Burns in Rats by Ameliorating Oxidative Stress and Mitochondrial-Related Apoptosis

Guo, S., Zhou, H., Huang, C.-L., You, C., Fang, Q., Wu, P., Wang, X., & Han, C. (2015) · Marine Drugs · doi:10.3390/md13042105 · Cited by 107 · see citing works

Mitochondrion‐Permeable Antioxidants to Treat ROS‐Burst‐Mediated Acute Diseases

Zhang, Z., Xu, X., Liu, T., & Yuan, S. (2015) · Oxidative Medicine and Cellular Longevity · doi:10.1155/2016/6859523 · Cited by 106 · see citing works

Regulation of Oxygenic Photosynthesis during Trophic Transitions in the Green Alga Chromochloris zofingiensis

Roth, M., Gallaher, S. D., Westcott, D. J., Iwai, M., Louie, K., Mueller, M., Walter, A., Foflonker, F., Bowen, B. P., Ataii, N. N., et al. (2019) · The Plant Cell · doi:10.1105/tpc.18.00742 · Cited by 106 · see citing works

An updated review on use of tomato pomace and crustacean processing waste to recover commercially vital carotenoids

Saini, R. K., Moon, S. H., & Keum, Y. (2018) · Food Research International · doi:10.1016/j.foodres.2018.04.003 · Cited by 105 · see citing works

Xanthophyll: Health benefits and therapeutic insights

Aziz, E., Batool, R., Akhtar, W., Rehman, S., Shahzad, T., Malik, A. M., Shariati, M. A., Laishevtcev, A. I., Plygun, S., Heydari, M., et al. (2019) · Life Sciences · doi:10.1016/j.lfs.2019.117104 · Cited by 105 · see citing works

Simple and fast HPLC method for simultaneous determination of retinol, tocopherols, coenzyme Q10 and carotenoids in complex samples

Gleize, B., Steib, M., André, M., & Reboul, E. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.04.043 · Cited by 104 · see citing works

Potential of natural astaxanthin in alleviating the risk of cytokine storm in COVID-19

Talukdar, J., Bhadra, B., Dattaroy, T., Nagle, V. L., & Dasgupta, S. (2020) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2020.110886 · Cited by 104 · see citing works

Pharmacokinetics of Marine-Derived Drugs

Shikov, A. N., Флисюк, Е. В., Obluchinskaya, E. D., & Pozharitskaya, O. N. (2020) · Marine Drugs · doi:10.3390/md18110557 · Cited by 102 · see citing works

Microalgae—Sustainable Source for Alternative Proteins and Functional Ingredients Promoting Gut and Liver Health

Eilam, Y., Khattib, H., Pintel, N., & Avni, D. (2023) · Global Challenges · doi:10.1002/gch2.202200177 · Cited by 101 · see citing works

Astaxanthin: An algae-based natural compound with a potential role in human health-promoting effect: An updated comprehensive review

Jinu, M., & Chandra, K. M. (2021) · Journal of Applied Biology & Biotechnology · doi:10.7324/jabb.2021.9115 · Cited by 16 · see citing works

Bioactive Properties of the Pigment Astaxanthin from Haematococcus pluvialis in Human Health

Galarza, J. I., Pillacela, B., & Arredondo-Vega, B. O. (2023) · Physiology · doi:10.5772/intechopen.112085

Extensive Bioactivity of Astaxanthin from Haematococcus pluvialis in Human

Yamashita, E. (2021) · Advances in experimental medicine and biology · doi:10.1007/978-981-15-7360-6_23 · Cited by 21 · see citing works

Haematococcus astaxanthin: applications for human health and nutrition

Guerin, M., Huntley, M. E., & Olaizola, M. (2003) · Trends in Biotechnology · doi:10.1016/s0167-7799(03)00078-7 · Cited by 1,495 · see citing works

Factors Affecting the Production of Astaxanthin in the Microalgae Haematococcus pluvialis: A Review

Soni, M., Aligita, W., Tina, R., & Levita, J. (2022) · International Journal of Current Research and Review · doi:10.31782/ijcrr.2022.141104 · Cited by 1 · see citing works