Compounds from the Roots and Rhizomes of Valeriana amurensis Protect against Neurotoxicity in PC12 Cells
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Three new germacrane-type sesquiterpenoids, heishuixiecaoline A-C (compounds 1-3), were isolated along with ten known compounds 4-13 from fraction of Valeriana amurensis roots and rhizomes effective against Alzheimer's disease (AD). The structures of 1-3 were elucidated on the basis of their spectroscopic data. We also investigated the protective effect of compounds 1-13 on the neurotoxicity of PC12 cells induced by amyloid-beta (Aβ(25-25)), respectively. As a result, germacrane-type sesquiterpenoids 1-4 and lignans 5-7 were seen to afford protection against Aβ-induced toxicity in PC 12 cells. This study will contribute to revealing the chemical basis for the therapeutic effect of V. amurensis against AD.
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Increasing acetylcholine concentration at the synapse by inhibiting AChE is one approach to slow down the progression of AD.
“An increase of acetylcholine concentration (ACh) at the synapse by inhibiting the acetylcholinesterase (AChE) is one of the approaches to slow down the progression of AD [18,19,20,21,22,23,24,25,26].”
From Acetylcholinesterase Inhibitory Potential of Various Sesquiterpene Analogues for Alzheimer’s Disease Therapy (2021) · cites this paper as [21]
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NATURAL PRODUCT FOR THE PREVENTION AND TREATMENT OF ALZHEIMER'S DISEASEPreprint
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- Authors
- Wang, Q., Wang, C., Zuo, Y., Wang, Z., Yang, B., & Kuang, H.
- Affiliations
- Heilongjiang University of Chinese Medicine (CN)
- Jiangxi University of Traditional Chinese Medicine (CN)
- Key Laboratory of Chinese Materia Medica (Ministry of Education), Heilongjiang University of Chinese Medicine, No. 24 HePing Road, XiangFang District, Harbin 150040, China
- Corresponding author
- Kuang, Haixue
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2012-12-18
- Volume
- 17
- Issue
- 12
- Pages
- 15013-15021
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6268518
- OpenAlex
- W2070056318
- Cited by
- 38
- References
- 20
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 3 · 2022: 6 · 2021: 2 · 2020: 2 · 2019: 2 · 2018: 3 · 2017: 1 · 2016: 4 · 2015: 5 · 2014: 2 · 2013: 3
- FWCI
- 1.06
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Topics
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Cancer Research › Sesquiterpenes and Asteraceae Studies
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plant Extracts Effects
- Keywords
- lignans, Alzheimer's disease, amyloid-beta toxicity, PC12 cells, neuroprotection, roots and rhizomes, natural product isolation
- MeSH terms
- Alzheimer Disease, Animals, Sesquiterpenes, Valerian, Amyloid beta-Peptides, PC12 Cells, Apoptosis, Lignans, Plant Roots, Neuroprotective Agents, Rhizome, Rats
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