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Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family
Open accessAbstract
The present study aimed to evaluate acetylcholinesterase (AChE) inhibitory and antioxidant activities of Lamiaceae medicinal plants growing wild in Croatia. Using Ellman’s colorimetric assay all tested ethanolic extracts and their hydroxycinnamic acid constituents demonstrated in vitro AChE inhibitory properties in a dose dependent manner. The extracts of Mentha x piperita, M. longifolia, Salvia officinalis, Satureja montana, Teucrium arduini, T. chamaedrys, T. montanum, T. polium and Thymus vulgaris at 1 mg/mL showed strong inhibitory activity against AChE. The antioxidant potential of the investigated Lamiaceae species was assessed by DPPH• scavenging activity and total antioxidant capacity assays, in comparison with hydroxycinnamic acids and trolox. The extracts differed greatly in their total hydroxycinnamic derivatives content, determined spectrophotometrically. Rosmarinic acid was found to be the predominant constituent in most of the investigated medicinal plants (by RP-HPLC) and had a substantial influence on their AChE inhibitory and antioxidant properties, with the exception of Teucrium species. These findings indicate that Lamiaceae species are a rich source of various natural AChE inhibitors and antioxidants that could be useful in the prevention and treatment of Alzheimer’s and other related diseases.
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“The FRAP assay is a well-known, reliable approach that measures ferric reducing ability in a redox-linked colorimetric reaction that reduces Fe3+ to Fe2+ [78–81].”
From Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae) (2020) · cites this paper as [79]
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Herbal beverages: Bioactive compounds and their role in disease risk reduction - A review
Chandrasekara, A., & Shahidi, F. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.08.006 · Cited by 306
Rosmarinic acid: modes of action, medicinal values and health benefits
Alagawany, M. M., El-Hack, M. E. A., Farag, M. R., Gopi, M., Karthik, K., Malik, Y. S., & Dhama, K. (2017) · Animal Health Research Reviews · doi:10.1017/s1466252317000081 · Cited by 224
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Metadata
- Authors
- Vladimir-Knežević, S., Blažeković, B., Kindl, M., Vladić, J., Lower-Nedza, A., & Brantner, A.
- Affiliations
- Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev trg 20, Zagreb 10000, Croatia
- University of Zagreb (HR)
- University of Novi Sad (RS)
- University of Graz (AT)
- Corresponding author
- Blažeković, Biljana
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-01-09
- Volume
- 19
- Issue
- 1
- Pages
- 767-782
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6271370
- OpenAlex
- W2001061645
- Semantic Scholar
- 21b840d6afb1cdea263f86ce901c1178f8819a54
- Cited by
- 238
- References
- 58
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 17 · 2023: 19 · 2022: 27 · 2021: 28 · 2020: 23 · 2019: 18 · 2018: 22 · 2017: 16 · 2016: 15 · 2015: 10 · 2014: 7
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- CEEPUS
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- acetylcholinesterase inhibition, antioxidant activity, Lamiaceae, medicinal plants, hydroxycinnamic acids, rosmarinic acid, Mentha, Salvia officinalis, Satureja, Teucrium, thyme, ethanolic plant extract, DPPH radical scavenging, Alzheimer's disease
- MeSH terms
- Rosmarinic Acid, Acetylcholinesterase, Alzheimer Disease, Animals, Biphenyl Compounds, Cholinesterase Inhibitors, Chromans, Chromatography, High Pressure Liquid, Cinnamates, Coumaric Acids, Eels, Free Radicals, Humans, Picrates, Plant Extracts, Plants, Medicinal, Free Radical Scavengers, Lamiaceae, Fish Proteins, Depsides, Drug Discovery, Chromatography, Reverse-Phase
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