The DOI matches its Crossref record; 58 of the 58 references it cites were found in a registry or an index.
Acetylcholinesterase Inhibitory, Antioxidant and Phytochemical Properties of Selected Medicinal Plants of the Lamiaceae Family
Open accessAbstract
The present study aimed to evaluate acetylcholinesterase (AChE) inhibitory and antioxidant activities of Lamiaceae medicinal plants growing wild in Croatia. Using Ellman’s colorimetric assay all tested ethanolic extracts and their hydroxycinnamic acid constituents demonstrated in vitro AChE inhibitory properties in a dose dependent manner. The extracts of Mentha x piperita, M. longifolia, Salvia officinalis, Satureja montana, Teucrium arduini, T. chamaedrys, T. montanum, T. polium and Thymus vulgaris at 1 mg/mL showed strong inhibitory activity against AChE. The antioxidant potential of the investigated Lamiaceae species was assessed by DPPH• scavenging activity and total antioxidant capacity assays, in comparison with hydroxycinnamic acids and trolox. The extracts differed greatly in their total hydroxycinnamic derivatives content, determined spectrophotometrically. Rosmarinic acid was found to be the predominant constituent in most of the investigated medicinal plants (by RP-HPLC) and had a substantial influence on their AChE inhibitory and antioxidant properties, with the exception of Teucrium species. These findings indicate that Lamiaceae species are a rich source of various natural AChE inhibitors and antioxidants that could be useful in the prevention and treatment of Alzheimer’s and other related diseases.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Figures
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
The check wasn’t confident either way, so it gives no verdict — never disputed.
In the citing paper
“The FRAP assay is a well-known, reliable approach that measures ferric reducing ability in a redox-linked colorimetric reaction that reduces Fe3+ to Fe2+ [78–81].”
From Comparative and Correlational Evaluation of the Phytochemical Constituents and Antioxidant Activity of Musa sinensis L. and Musa paradisiaca L. Fruit Compartments (Musaceae) (2020) · cites this paper as [79]
Experimental — accuracy not yet measured
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Pathways towards and Away from Alzheimer’s Disease
Mattson, M. P. (2004) · Nature · doi:10.1038/nature02621 · Cited by 3,052
Petersen, M. (2002) · Phytochemistry · doi:10.1016/s0031-9422(02)00513-7 · Cited by 1,265
In vitro and in vivo antioxidant properties of chlorogenic acid and caffeic acid
Sato, Y., Itagaki, S., Kurokawa, T., Ogura, J., Kobayashi, M., Hirano, T., Sugawara, M., & Iseki, K. (2010) · International Journal of Pharmaceutics · doi:10.1016/j.ijpharm.2010.09.035 · Cited by 967
Radical scavenging ability of polyphenolic compounds towards DPPH free radical
Villaño, D., Fernández‐Pachón, M., Moyá, M. L., Troncoso, A. M., & García-Parrilla, M. C. (2006) · Talanta · doi:10.1016/j.talanta.2006.03.050 · Cited by 939
Acetylcholinesterase inhibitors from plants
Mukherjee, P. K., Kumar, V., Mal, M., & Houghton, P. J. (2007) · Phytomedicine · doi:10.1016/j.phymed.2007.02.002 · Cited by 809
A review of the bioactivity and potential health benefits of peppermint tea ( Mentha piperita L.)
McKay, D. L., & Blumberg, J. B. (2006) · Phytotherapy Research · doi:10.1002/ptr.1936 · Cited by 670
Ferreira, A., Proença, C., Serralheiro, M. L. M., & Araújo, M. E. M. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2006.04.010 · Cited by 480
Major flavonoids with antioxidant activity from Teucrium polium L.
Sharififar, F., Dehghn-Nudeh, G., & Mirtajaldini, M. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.06.064 · Cited by 417
Antioxidant and antiacetylcholinesterase activities of five plants used as Portuguese food spices
Mata, A. T., Proença, C. S., Ferreira, A. R., Serralheiro, M. L., Nogueira, J. M. F., & Araújo, M. E. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.09.017 · Cited by 403
Antioxidant and prooxidant nature of hydroxycinnamic acid derivatives ferulic and caffeic acids
Maurya, D. K., & Devasagayam, T. P. A. (2010) · Food and Chemical Toxicology · doi:10.1016/j.fct.2010.09.006 · Cited by 357
Teixeira, B., Marques, A., Ramos, C., Serrano, C., Matos, O., Neng, N. R., Nogueira, J. M. F., Saraiva, J. A., & Nunes, M. L. (2013) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.6089 · Cited by 315
Thompson, J. D., Chalchat, J., Michet, A., Linhart, Y. B., & Ehlers, B. (2003) · Journal of Chemical Ecology · doi:10.1023/a:1022927615442 · Cited by 292
Flavonoid and phenolic glycosides from Salvia officinalis
Lu, Y., & Foo, L. Y. (2000) · Phytochemistry · doi:10.1016/s0031-9422(00)00309-5 · Cited by 268
Russo, A., Formisano, C., Rigano, D., Senatore, F., Delfine, S., Cardile, V., Rosselli, S., & Bruno, M. (2013) · Food and Chemical Toxicology · doi:10.1016/j.fct.2012.12.036 · Cited by 235
Petersen, M. (2013) · Phytochemistry Reviews · doi:10.1007/s11101-013-9282-8 · Cited by 222
Kivilompolo, M., & Hyötyläinen, T. (2007) · Journal of Chromatography A · doi:10.1016/j.chroma.2007.01.090 · Cited by 209
(2002) · CRC Press eBooks · doi:10.1201/9780203216521 · Cited by 207
Adsersen, A., Gauguin, B., Gudiksen, L., & Jäger, A. K. (2006) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2005.09.032 · Cited by 205
Variation of free phenolic acids in medicinal plants belonging to the Lamiaceae family
Zgórka, G., & Głowniak, K. (2001) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/s0731-7085(01)00354-5 · Cited by 203
Orhan, İ. E., Aslan, S., Kartal, M., Şener, B., & Başer, K. H. C. (2007) · Food Chemistry · doi:10.1016/j.foodchem.2007.11.023 · Cited by 182
Beyond the Cholinergic Hypothesis: Do Current Drugs Work in Alzheimer's Disease?
Martorana, A., Esposito, Z., & Koch, G. (2010) · CNS Neuroscience & Therapeutics · doi:10.1111/j.1755-5949.2010.00175.x · Cited by 174
Flavonoids and Phenolic Compounds from Rosmarinus officinalis
Bai, N., He, K., Roller, M., Lai, C., Shao, X., Pan, M., & Ho, C. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100332w · Cited by 173
The ecological aspect of ethnobotany and ethnopharmacology of population in Bosnia and Herzegovina.
Redžić, S. (2007) · PubMed · Cited by 173
Rosmarinic acid and its derivatives: biotechnology and applications
Bulgakov, V. P., Inyushkina, Y. V., & Fedoreyev, S. A. (2011) · Critical Reviews in Biotechnology · doi:10.3109/07388551.2011.596804 · Cited by 171
Antioxidant Activities and Polyphenolic Contents of Three Selected Micromeria Species from Croatia
Vladimir-Knežević, S., Blažeković, B., Bival Štefan, M., Alegro, A., Kőszegi, T., & Petrik, J. (2011) · Molecules · doi:10.3390/molecules16021454 · Cited by 161
Self-citationFecka, I., & Turek, S. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf072284d · Cited by 152 · cited 2×
“HPLC Analysis The hydroxycinnamic acids composition of the selected Lamiaceae species was studied using a slightly modified method of Fecka and Turek [59].”
MethodTerpenoids as Potential Anti-Alzheimer’s Disease Therapeutics
Yoo, K.-Y., & Park, S. (2012) · Molecules · doi:10.3390/molecules17033524 · Cited by 151
Screening of traditionally used Lebanese herbs for neurological activities
Salah, S. M., & Jäger, A. K. (2004) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2004.10.023 · Cited by 144
Conforti, F., Statti, G. A., Tundis, R., Loizzo, M. R., & Menichini, F. (2007) · Phytotherapy Research · doi:10.1002/ptr.2077 · Cited by 122
Fale, P. L. V., Borges, C., Madeira, P. J. A., Ascensão, L., Araújo, M. E., Florêncio, M. H., & Serralheiro, M. L. (2008) · Food Chemistry · doi:10.1016/j.foodchem.2008.10.015 · Cited by 113
Orhan, İ. E., & Aslan, M. (2008) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2008.12.026 · Cited by 107
Phytochemicals as Nutraceuticals - Global Approaches to Their Role in Nutrition and Health
Rao, V. (2012) · InTech eBooks · doi:10.5772/2375 · Cited by 106
Antioxidant approaches for the treatment of Alzheimer’s disease
Lee, H. P., Zhu, X., Casadesús, G., Castellani, R. J., Nunomura, A., Smith, M. A., Lee, H., & Perry, G. L. (2010) · Expert Review of Neurotherapeutics · doi:10.1586/ern.10.74 · Cited by 104
Blažeković, B., Vladimir-Knežević, S., Brantner, A., & Štefan, M. B. (2010) · Molecules · doi:10.3390/molecules15095971 · Cited by 95
Self-citationAcetylcholinesterase inhibitory guided fractionation of Melissa officinalis L.
Dastmalchi, K., Ollilainen, V., Lackman, P., af Gennäs, G. B., Dorman, H. J. D., Järvinen, P. P., Yli‐Kauhaluoma, J. T., & Hiltunen, R. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.11.034 · Cited by 91
Viapiana, A., & Wesołowski, M. (2013) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2013.05.020 · Cited by 89
Investigating the Antioxidant and Acetylcholinesterase Inhibition Activities of Gossypium herbaceam
Zhao, Y., Dou, J., Wu, T., & Aisa, H. A. (2013) · Molecules · doi:10.3390/molecules18010951 · Cited by 81
Plant Polyphenols as Antioxidants Influencing the Human Health
Vladimir-Kneevic, S., Blaekovi, B., Bival, M., & Babac, M. (2012) · InTech eBooks · doi:10.5772/27843 · Cited by 74
Self-citationSilva, F., Martins, A., Salta, J., Neng, N. R., Nogueira, J. M. F., Mira, D., Gaspar, N., Justino, J., Grosso, C., Urieta, J. S., et al. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf901786p · Cited by 64
Acacetin glycosides as taxonomic markers in Calamintha and Micromeria
Marin, P. D., Grayer, R. J., Veitch, N. C., Kite, G. C., & Harborne, J. B. (2001) · Phytochemistry · doi:10.1016/s0031-9422(01)00352-1 · Cited by 64
Screening the methanol extracts of some Iranian plants for acetylcholinesterase inhibitory activity.
Gholamhoseinian, A., Moradi, M.-N., & Sharififar, F. (2009) · PubMed Central · Cited by 59
Pharmacotherapeutic targets in Alzheimer's disease
Biran, Y., Masters, C. L., Barnham, K. J., Bush, A. I., & Adlard, P. A. (2008) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2008.00595.x · Cited by 59
Alzheimer’s Disease and Antioxidant Therapy: How Long How Far?
Teixeira, J., Silva, T., Andrade, P. B., & Borges, F. (2013) · Current Medicinal Chemistry · doi:10.2174/1871523011320240001 · Cited by 59
PROOXIDANT AND ANTIOXIDANT ACTIVITIES OF ROSMARINIC ACID
Muñoz-Muñoz, J., Garcı́a-Molina, F., ROS, E., Tudela, J., Garcı́a-Cánovas, F., & Rodríguez‐López, J. N. (2012) · Journal of Food Biochemistry · doi:10.1111/j.1745-4514.2011.00639.x · Cited by 52
Screening for acetylcholinesterase inhibitory activity in plant extracts from Argentina
Carpinella, M. C., Andrione, D. G., Ruiz, G., & Palacios, S. M. (2009) · Phytotherapy Research · doi:10.1002/ptr.2923 · Cited by 47
Kovatcheva-Apostolova, E. G., Georgiev, M. I., Ilieva, M. P., Skibsted, L. H., Rødtjer, A., & Andersen, M. L. (2008) · European Food Research and Technology · doi:10.1007/s00217-008-0842-x · Cited by 44
Total Hydroxycinnamic Acids Assay: Prevalidation and Application on Lamiaceae Species
Štefan, M. B., Rodríguez, J. V., Blažeković, B., Kindl, M., & Vladimir‐Knežević, S. (2013) · Food Analytical Methods · doi:10.1007/s12161-013-9630-8 · Cited by 39
Self-citationFernández, L. F., Palomino, O. M., & Frutos, G. (2013) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2013.11.006 · Cited by 38
Composition of the Essential Oils of ThreeTeucriumSpecies from Turkey
Başer, K. H. C., Demirçakmak, B., & Duman, H. (1997) · Journal of Essential Oil Research · doi:10.1080/10412905.1997.9700774 · Cited by 36
Phytochemistry of the genus Lavandula
Harborne, J. B., & Williams, C. A. (2002) · CRC Press eBooks · doi:10.1201/9780203216521-14 · Cited by 35
ISOLATION AND IDENTIFICATION OF ANTIOXIDATIVE FLAVONOID GLYCOSIDES FROM THYME (THYMUS VULGARIS L.)
Wang, M., LI, J., Ho, G. S., Peng, X., & Ho, C. (1998) · Journal of Food Lipids · doi:10.1111/j.1745-4522.1998.tb00127.x · Cited by 27
Analysis of polyphenols, phytosterols, and bitter principles in Teucrium L. species
Grubešić, R. J., Kremer, D., Vladimir‐Knežević, S., & Rodríguez, J. V. (2012) · Open Life Sciences · doi:10.2478/s11535-012-0040-5 · Cited by 21
Self-citationOrhan, İ. E., Şenol, F. S., Demırcı, B., Öztürk, N., Başer, K. H. C., & Şener, B. (2012) · Food Analytical Methods · doi:10.1007/s12161-012-9386-6 · Cited by 19
Dinis, P. (2013) · European Journal of Medicinal Plants · doi:10.9734/ejmp/2013/3430 · Cited by 16
Essential‐Oil Diversity of Three Calamintha Species from Greece
Karousou, R., Hanlidou, E., & Lazari, D. M. (2012) · Chemistry & Biodiversity · doi:10.1002/cbdv.201100262 · Cited by 16
Öztürk, M., Kolak, U., Duru, M. E., & Harmandar, M. (2009) · Natural Product Communications · doi:10.1177/1934578x0900400923 · Cited by 14
Vladimir‐Knežević, S., Kalođera, Z., & Blažević, N. (2000) · PubMed · Cited by 8
Self-citationVladimir-Kneevic, S., Blaekovic, B., Tefan, M. B., & Alegro, A. (2010) · Planta Medica · doi:10.1055/s-0030-1264550 · Cited by 4
Research works printed but not linked: 2
- Dastmalchi, 2007, Plants as potential source for drug development against Alzheimer’s disease, Int. J. Biomed. Pharmaceut. Sci., 1, 83
- 2007, Plant uses in Croatia, Phytol. Balcan., 13, 229
Cited by
Sorted by citations
Herbal beverages: Bioactive compounds and their role in disease risk reduction - A review
Chandrasekara, A., & Shahidi, F. (2018) · Journal of Traditional and Complementary Medicine · doi:10.1016/j.jtcme.2017.08.006 · Cited by 306
Rosmarinic acid: modes of action, medicinal values and health benefits
Alagawany, M. M., El-Hack, M. E. A., Farag, M. R., Gopi, M., Karthik, K., Malik, Y. S., & Dhama, K. (2017) · Animal Health Research Reviews · doi:10.1017/s1466252317000081 · Cited by 224
Juszczyk, G., Mikulska, J., Kasperek, K., Pietrzak, D., Mrozek, W., & Herbet, M. (2021) · Antioxidants · doi:10.3390/antiox10091439 · Cited by 247
Production and applications of rosmarinic acid and structurally related compounds
Kim, G., Park, Y. S., Jin, Y., & Park, C. (2015) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-015-6395-6 · Cited by 156
An ethnomedicinal survey of a Tashelhit-speaking community in the High Atlas, Morocco
Teixidor‐Toneu, I., Martin, G. J., Ouhammou, A., Puri, R. K., & Hawkins, J. A. (2016) · Journal of Ethnopharmacology · doi:10.1016/j.jep.2016.05.009 · Cited by 155
Metadata
- Authors
- Vladimir-Knežević, S., Blažeković, B., Kindl, M., Vladić, J., Lower-Nedza, A., & Brantner, A.
- Affiliations
- Department of Pharmacognosy, Faculty of Pharmacy and Biochemistry, University of Zagreb, Marulićev trg 20, Zagreb 10000, Croatia
- University of Zagreb (HR)
- University of Novi Sad (RS)
- University of Graz (AT)
- Corresponding author
- Blažeković, Biljana
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-01-09
- Volume
- 19
- Issue
- 1
- Pages
- 767-782
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6271370
- OpenAlex
- W2001061645
- Semantic Scholar
- 21b840d6afb1cdea263f86ce901c1178f8819a54
- Cited by
- 238
- References
- 58
- Citations by year
- 2026: 16 · 2025: 20 · 2024: 17 · 2023: 19 · 2022: 27 · 2021: 28 · 2020: 23 · 2019: 18 · 2018: 22 · 2017: 16 · 2016: 15 · 2015: 10 · 2014: 7
- FWCI
- 10.91
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- CEEPUS
- Topics
- Health Sciences › Medicine › Pharmacology (medical) › Cholinesterase and Neurodegenerative Diseases
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Complementary and alternative medicine › Medicinal Plants and Neuroprotection
- Keywords
- acetylcholinesterase inhibition, antioxidant activity, Lamiaceae, medicinal plants, hydroxycinnamic acids, rosmarinic acid, Mentha, Salvia officinalis, Satureja, Teucrium, thyme, ethanolic plant extract, DPPH radical scavenging, Alzheimer's disease
- MeSH terms
- Rosmarinic Acid, Acetylcholinesterase, Alzheimer Disease, Animals, Biphenyl Compounds, Cholinesterase Inhibitors, Chromans, Chromatography, High Pressure Liquid, Cinnamates, Coumaric Acids, Eels, Free Radicals, Humans, Picrates, Plant Extracts, Plants, Medicinal, Free Radical Scavengers, Lamiaceae, Fish Proteins, Depsides, Drug Discovery, Chromatography, Reverse-Phase
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
