Cited by 480Cholinesterase and Neurodegenerative DiseasesEssential Oils and Antimicrobial ActivityPhytochemistry and Biological Activities

The in vitro screening for acetylcholinesterase inhibition and antioxidant activity of medicinal plants from Portugal

Ferreira, A., Proença, C., Serralheiro, M.L.M., Araújo, M.E.M.·2006·Journal of Ethnopharmacology

Abstract

Essential oil, ethanolic extract and decoction of 10 plant species from interior Portugal were analyzed for their activity towards acetylcholinesterase (AChE) enzyme and their antioxidant activity. Of these, Melissa officinalis, Paronychia argentea, Sanguisorba minor, Hypericum undulatum and Malva silvestris are used in herbal medicine, Laurus nobilis and Mentha suaveolens as condiments, and Salvia officinalis, Lavandula angustifolia and Lavandula pedunculata also as aromatics. Melissa officinalis and Mentha suaveolens showed AChE inhibitory capacity higher then 50% in the essential oil fraction. Laurus nobilis, Hypericum undulatum, and Sanguisorba minor showed a high inhibition value of AChE in the ethanolic fraction, 64% (1 mg ml(-1)) 68% (0.5 mg ml(-1)), and 78% (1 mg ml(-1)), respectively. Higher values of AChE inhibitory activity were found using decoctions of Lavandula pedunculata, Mentha suaveolens and Hypericum undulatum, 68, 69 and 82% (at a concentration of 5mg dry plant ml(-1) of assay), respectively. The free radical scavenger activity was higher for the polar extracts. In the water extracts most of the plants showed values around 90%. When antioxidant activity was measured with the beta-carotene-linoleic acid assay high activity (65-95%) was also found in the water extracts. Hypericum undulatum, Melissa officinalis and Laurus nobilis showed both high AChE inhibitory capacity and antioxidant activity.

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Crossref · 10.1016/j.jep.2006.04.010

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Authors
Ferreira, A., Proença, C., Serralheiro, M. L. M., & Araújo, M. E. M.
Affiliations
University of Lisbon (PT)
Corresponding author
Araújo, M.E.M.
Venue
Journal of Ethnopharmacology
Publisher
Elsevier BV
Published
2006-11
Volume
108
Issue
1
Pages
31-37
ISSN
0378-8741 (ISSN-L)
OpenAlex
W2079977910
Cited by
480
References
33
Citations by year
2026: 7 · 2025: 11 · 2024: 23 · 2023: 28 · 2022: 30 · 2021: 31 · 2020: 38 · 2019: 33 · 2018: 35 · 2017: 19 · 2016: 31 · 2015: 29 · 2014: 29 · 2013: 31 · 2012: 26
FWCI
8.98
Type
journal article
Language
en
Open access
closed
Locations
  • Journal of Ethnopharmacology (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Health Sciences › Medicine › Pharmacology › Cholinesterase and Neurodegenerative Diseases
  • Life Sciences › Agricultural and Biological Sciences › Food Science › Essential Oils and Antimicrobial Activity
  • Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
Keywords
acetylcholinesterase inhibition, antioxidant activity, medicinal plants, Portuguese flora, essential oils, ethanol extract, decoction, lemon balm, Mentha suaveolens, Lavandula, Laurus nobilis, Sanguisorba minor, free radical scavenging, β-carotene/linoleic acid assay, herbal medicine
MeSH terms
Antioxidants, Cholinesterase Inhibitors, Drug Evaluation, Preclinical, Plant Oils, Plants, Medicinal, Portugal, Plant Preparations

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