Bioactive profiles, antioxidant activities, nitrite scavenging capacities and protective effects on H2O2-injured PC12 cells of Glycyrrhiza Glabra L. leaf and root extracts
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This study compared the total flavonoid content of Glycyrrhiza glabra L. leaf and root extracts. Results suggested that the total flavonoid content in the leaf extract was obviously higher than that in the root extract. Pinocembrin, the main compound in the leaf extract after purification by column chromatography, showed good antioxidant activity and nitrite scavenging capacity, but moderate inhibitory effect on mushroom tyrosinase. Liquiritin was the main compound in root extract and possessed strong inhibitory effect on mushroom tyrosinase. Both compounds exhibited significant protection effect on H2O2-injured PC12 cells at a low concentration. These results indicate that Glycyrrhiza glabra L. leaf is potential as an important raw material for functional food.
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Pinocembrin, the main compound in G. glabra leaves, has a moderate inhibitory effect on mushroom tyrosinase.
“Pinocembrin, the main compound in G. glabra leaves, is reported to have a moderate inhibitory effect on mushroom tyrosinase [43].”
From Licorice (Glycyrrhiza glabra, G. uralensis, and G. inflata) and Their Constituents as Active Cosmeceutical Ingredients (2022) · cites this paper as [43]
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- Authors
- Dong, Y., Zhao, M., Zhao, T., Feng, M., Chen, H., Zhuang, M., & Lin, L.
- Affiliations
- South China University of Technology (CN)
- State Key Laboratory of Pulp and Paper Engineering (CN)
- Corresponding author
- Lin, Lianzhu
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2014-06-30
- Volume
- 19
- Issue
- 7
- Pages
- 9101-9113
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6270937
- OpenAlex
- W1986635189
- Cited by
- 47
- References
- 27
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 5 · 2023: 3 · 2022: 7 · 2021: 5 · 2019: 5 · 2018: 2 · 2017: 6 · 2016: 7
- FWCI
- 4.98
- Type
- journal article
- Language
- en
- Open access
- gold
- doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Topics
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmacology › Pharmacological Effects of Natural Compounds
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Phytochemistry and Biological Activities
- Health Sciences › Medicine › Biochemistry › Phytochemicals and Antioxidant Activities
- Keywords
- licorice, licorice extract, total flavonoid content, pinocembrin, liquiritin, antioxidant activity, nitrite scavenging, hydrogen peroxide stress, PC12 cells, neuroprotection, functional food ingredients
- MeSH terms
- Animals, Glucosides, Glycyrrhiza, Hydrogen Peroxide, Nitrites, Plant Extracts, Monophenol Monooxygenase, Free Radical Scavengers, PC12 Cells, Plant Leaves, Plant Roots, Cytoprotection, Flavanones, Cell Shape, Rats
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