1-Deoxynojirimycin: Occurrence, Extraction, Chemistry, Oral Pharmacokinetics, Biological Activities and In Silico Target Fishing

Mechanisms of nutritional and hormonal regulation of lipogenesis

Kersten, S. (2001) · The EMBO Reports · doi:10.1093/embo-reports/kve071 · Cited by 700 · see citing works

Glycosidase mechanisms: anatomy of a finely tuned catalyst.

Zechel, D. L., & Withers, S. G. (2000) · Accounts of Chemical Research · doi:10.1021/ar970172+ · Cited by 698 · see citing works

Polyphenols and prevention of cardiovascular diseases

Manach, C., Mazur, A., & Scalbert, A. (2005) · Current Opinion in Lipidology · doi:10.1097/00041433-200502000-00013 · Cited by 680 · see citing works

Chemical composition of white (Morus alba), red (Morus rubra) and black (Morus nigra) mulberry fruits

Erċışlı, S., & Orhan, E. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.10.054 · Cited by 662 · see citing works

Dietary polyphenols: Good, bad, or indifferent for your health?

Halliwell, B. B. (2006) · Cardiovascular Research · doi:10.1016/j.cardiores.2006.10.004 · Cited by 558 · see citing works

Determination of amino acids with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography

Einarsson, S., Josefsson, B., & Lagerkvist, S. (1983) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)91638-8 · Cited by 557 · see citing works

Antioxidant properties of various solvent extracts of mulberry (Morus indica L.) leaves

Arabshahi-Delouee, S., & Urooj, A. (2006) · Food Chemistry · doi:10.1016/j.foodchem.2006.07.013 · Cited by 523 · see citing works

Therapeutic target database update 2012: a resource for facilitating target-oriented drug discovery

Zhu, F., Shi, Z., Qin, C., Tao, L., Liu, X., Xu, F., Zhang, L., Song, Y., Liu, X., Zhang, J., et al. (2011) · Nucleic Acids Research · doi:10.1093/nar/gkr797 · Cited by 479 · see citing works

Analysis of Highly Polar Compounds of Plant Origin: Combination of Hydrophilic Interaction Chromatography and Electrospray Ion Trap Mass Spectrometry

Tolstikov, V., & Fiehn, O. (2002) · Analytical Biochemistry · doi:10.1006/abio.2001.5513 · Cited by 472 · see citing works

?-Glucosidase inhibitors

Schmidt, D. D., Frommer, W., Junge, B., M�ller, L., Wingender, W., Truscheit, E., & Sch�fer, D. (1977) · Die Naturwissenschaften · doi:10.1007/bf00483561 · Cited by 467 · see citing works

A short review of the fruit germplasm resources of Turkey

Erċışlı, S. (2004) · Genetic Resources and Crop Evolution · doi:10.1023/b:gres.0000023458.60138.79 · Cited by 393 · see citing works

Polyhydroxylated Alkaloids Isolated from Mulberry Trees (Morus alba L.) and Silkworms (Bombyx mori L.)

Asano, N., Yamashita, T., Yasuda, K., Ikeda, K., Kizu, H., Kameda, Y., Kato, A., Nash, R. J., Lee, H.-S., & Ryu, K. (2001) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf010567e · Cited by 391 · see citing works

Structure and synthesis of nojirimycin

Inouye, S., Tsuruoka, T., Itô, T., & NIIDA, T. (1968) · Tetrahedron · doi:10.1016/0040-4020(68)88115-3 · Cited by 379 · see citing works

Food-Grade Mulberry Powder Enriched with 1-Deoxynojirimycin Suppresses the Elevation of Postprandial Blood Glucose in Humans

Kimura, T., Nakagawa, K., Kubota, H., Kojima, Y., Goto, Y., Yamagishi, K., Oita, S., Oikawa, S., & Miyazawa, T. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf062680g · Cited by 342 · see citing works

From in silico target prediction to multi-target drug design: Current databases, methods and applications

Koutsoukas, A., Simms, B., Kirchmair, J., Bond, P. J., Whitmore, A. V., Zimmer, S., Young, M. P., Jenkins, J. L., Glick, M., Glen, R. C., et al. (2011) · Journal of Proteomics · doi:10.1016/j.jprot.2011.05.011 · Cited by 287 · see citing works

Intestinal sugar transport

Drozdowski, L. A. (2006) · World Journal of Gastroenterology · doi:10.3748/wjg.v12.i11.1657 · Cited by 275 · see citing works

Morus alba L. nature's functional tonic

Butt, M. S., Nazir, A., Sultan, M. T., & Schroën, K. G. P. H. (2008) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2008.06.002 · Cited by 264 · see citing works

The mechanism of alpha-glucosidase inhibition in the management of diabetes.

Bischoff, H. (1995) · PubMed · Cited by 234 · see citing works

Recent Advances in the Total Synthesis of Piperidine Azasugars

Pearson-Long, M. S. M., Mathé‐Allainmat, M., Fargeas, V., & Lebreton, J. (2005) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200400823 · Cited by 217 · see citing works

Phytochemical Profiles of Different Mulberry ( Morus sp.) Species from China

Song, W., Wang, H.-J., Bucheli, P., Zhang, P., Wei, D., & Lü, Y. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf9022228 · Cited by 194 · see citing works

Mulberroside F Isolated from the Leaves of Morus alba Inhibits Melanin Biosynthesis.

Lee, S. E., Choi, S. Y., Kim, H., Hwang, J. S., Lee, B. G., Gao, J., & Kim, S. Y. (2002) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.25.1045 · Cited by 193 · see citing works

In silico target fishing: Predicting biological targets from chemical structure

Jenkins, J. L., Bender, A., & Davies, J. W. (2006) · Drug Discovery Today Technologies · doi:10.1016/j.ddtec.2006.12.008 · Cited by 190 · see citing works

Evaluation of Different Teas against Starch Digestibility by Mammalian Glycosidases

Koh, L. W., Wong, L. L., Loo, Y. Y., Kasapis, S., & Huang, D. (2009) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf903011g · Cited by 189 · see citing works

Starch Digestion and Absorption in Nonruminants , ,

Gray, G. M. (1992) · Journal of Nutrition · doi:10.1093/jn/122.1.172 · Cited by 183 · see citing works

Determination of 1-deoxynojirimycin in Morus alba L. leaves by derivatization with 9-fluorenylmethyl chloroformate followed by reversed-phase high-performance liquid chromatography

Kim, J., Kim, S.-U., Lee, H. S., Kim, I., Ahn, M. Y., & Ryu, K. (2003) · Journal of Chromatography A · doi:10.1016/s0021-9673(03)00728-3 · Cited by 169 · see citing works

Therapeutic Applications of Imino Sugars in Lysosomal Storage Disorders

Butters, T. D., Dwek, R. A., & Platt, F. M. (2003) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026033452483 · Cited by 156 · see citing works

The alpha-glucosidase inhibitor N-butyldeoxynojirimycin inhibits human immunodeficiency virus entry at the level of post-CD4 binding

Fischer, P. B., Collin, M., Karlsson, G. B., James, W., Butters, T. D., Davis, S. J., Gordon, S., Dwek, R. A., & Platt, F. M. (1995) · Journal of Virology · doi:10.1128/jvi.69.9.5791-5797.1995 · Cited by 155 · see citing works

Study of the Mechanism of Antiviral Action of Iminosugar Derivatives against Bovine Viral Diarrhea Virus

Durantel, D., Branza‐Nichita, N., Carrouée‐Durantel, S., Butters, T. D., Dwek, R. A., & Zitzmann, N. (2001) · Journal of Virology · doi:10.1128/jvi.75.19.8987-8998.2001 · Cited by 155 · see citing works

Hypoglycemic Activity and Mechanisms of Extracts from Mulberry Leaves (Folium Mori) and Cortex Mori Radicis in Streptozotocin-Induced Diabetic Mice

Fujun, C. H. E. N., Nakashima, N., Kimura, I., & KIMURA, M. (1995) · YAKUGAKU ZASSHI · doi:10.1248/yakushi1947.115.6_476 · Cited by 130 · see citing works

Effect of mulberry leaf extract with enriched 1-deoxynojirimycin content on postprandial glycemic control in subjects with impaired glucose metabolism

Asai, A., Nakagawa, K., Higuchi, O., Kimura, T., Kojima, Y., Kariya, J., Miyazawa, T., & Oikawa, S. (2011) · Journal of Diabetes Investigation · doi:10.1111/j.2040-1124.2011.00101.x · Cited by 116 · see citing works

Molecular characterisation of carbohydrate digestion and absorption in equine small intestine

Dyer, J., MEREDIZ, E. F., Salmon, K. S. H., PROUDMAN, C. J., Edwards, G. B., & Shirazi‐Beechey, S. P. (2002) · Equine Veterinary Journal · doi:10.2746/042516402776249209 · Cited by 108 · see citing works

Intake of mulberry 1-deoxynojirimycin prevents diet-induced obesity through increases in adiponectin in mice

Tsuduki, T., Kikuchi, I., Kimura, T., Nakagawa, K., & Miyazawa, T. (2013) · Food Chemistry · doi:10.1016/j.foodchem.2013.02.025 · Cited by 105 · see citing works

1-deoxynojirimycin inhibits glucose absorption and accelerates glucose metabolism in streptozotocin-induced diabetic mice

Li, Y., Ji, D.-F., Zhong, S. S., Tian-bao, L. I. N., Lv, Z.-Q., Hu, G.-Y., & Wang, X. (2013) · Scientific Reports · doi:10.1038/srep01377 · Cited by 105 · see citing works

Effects of Mulberry Leaf Extract Rich in 1-Deoxynojirimycin on Blood Lipid Profiles in Humans

Kojima, Y., Kimura, T., Nakagawa, K., Asai, A., Hasumi, K., Oikawa, S., & Miyazawa, T. (2010) · Journal of Clinical Biochemistry and Nutrition · doi:10.3164/jcbn.10-53 · Cited by 104 · see citing works

Miglitol, a new α-glucosidase inhibitor

Sels, J.-P. J. E., Huijberts, M. S., & Wolffenbuttel, B. H. R. (1999) · Expert Opinion on Pharmacotherapy · doi:10.1517/14656566.1.1.149 · Cited by 103 · see citing works

Determination of 1-Deoxynojirimycin in Mulberry Leaves Using Hydrophilic Interaction Chromatography with Evaporative Light Scattering Detection

Kimura, T., Nakagawa, K., Saito, Y., Yamagishi, K., Suzuki, M., Yamaki, K., Shinmoto, H., & Miyazawa, T. (2004) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf0306901 · Cited by 98 · see citing works

Antiobesity Effects and Improvement of Insulin Sensitivity by 1-Deoxynojirimycin in Animal Models

Kong, W.-H., Oh, S.-H., Ahn, Y.-R., Kim, K., Kim, J.-H., & Seo, S.-W. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf073223i · Cited by 98 · see citing works

Sensitive fluorimetric determination of gentamicin sulfate in biological matrices using solid-phase extraction, pre-column derivatization with 9-fluorenylmethyl chloroformate and reversed-phase high-performance liquid chromatography

Stead, D., & Richards, R. M. E. (1996) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(95)00355-x · Cited by 89 · see citing works

Quantitative determination of 1-deoxynojirimycin in mulberry leaves using liquid chromatography–tandem mass spectrometry

Nuengchamnong, N., Ingkaninan, K., Kaewruang, W., Wongareonwanakij, S., & Hongthongdaeng, B. (2007) · Journal of Pharmaceutical and Biomedical Analysis · doi:10.1016/j.jpba.2007.03.031 · Cited by 88 · see citing works

Novel Imino Sugar Derivatives Demonstrate Potent Antiviral Activity against Flaviviruses

Chang, J., Wang, L., Ma, D., Qu, X., Guo, H., Xu, X., Mason, P. M., Bourne, N., Moriarty, R. M., Gu, B., et al. (2009) · Antimicrobial Agents and Chemotherapy · doi:10.1128/aac.01457-08 · Cited by 86 · see citing works

Quantitative determination of 1-deoxynojirimycin in mulberry leaves from 132 varieties

Hu, X., Jiang, L., Zhang, J.-G., Deng, W., Wang, H.-L., & Wei, Z. (2013) · Industrial Crops and Products · doi:10.1016/j.indcrop.2013.06.030 · Cited by 85 · see citing works

Production of the α-glycosidase inhibitor 1-deoxynojirimycin from Bacillus species

Onose, S., Ikeda, R., Nakagawa, K., Kimura, T., Yamagishi, K., Higuchi, O., & Miyazawa, T. (2012) · Food Chemistry · doi:10.1016/j.foodchem.2012.11.012 · Cited by 84 · see citing works

The α-Glucosidase Inhibitor 1-Deoxynojirimycin Blocks Human Immunodeficiency Virus Envelope Glycoprotein-Mediated Membrane Fusion at the CXCR4 Binding Step

Papandréou, M., Barbouche, R., Guieu, R., Kiény, M. P., & Fenouillet, E. (2002) · Molecular Pharmacology · doi:10.1124/mol.61.1.186 · Cited by 83 · see citing works

Mulberry leaf extract prevents amyloid beta-peptide fibril formation and neurotoxicity

Niidome, T., Takahashi, K., Goto, Y., Goh, S., Tanaka, N., Kamei, K., Ichida, M., Hara, S., Akaike, A., Kihara, T., et al. (2007) · Neuroreport · doi:10.1097/wnr.0b013e3280dce5af · Cited by 83 · see citing works

1-Deoxynojirimycin Alleviates Insulin Resistance via Activation of Insulin Signaling PI3K/AKT Pathway in Skeletal Muscle of db/db Mice

Liu, Q., Li, X., Li, C., Zheng, Y., & Peng, G. (2015) · Molecules · doi:10.3390/molecules201219794 · Cited by 80 · see citing works

The relationship between 1-deoxynojirimycin content and α-glucosidase inhibitory activity in leaves of 276 mulberry cultivars (Morus spp.) in Kyoto, Japan

Yatsunami, K., Ichida, M., & Onodera, S. (2007) · Journal of Natural Medicines · doi:10.1007/s11418-007-0185-0 · Cited by 78 · see citing works

Development of high 1-deoxynojirimycin (DNJ) content mulberry tea and use of response surface methodology to optimize tea-making conditions for highest DNJ extraction

Vichasilp, C., Nakagawa, K., Sookwong, P., Higuchi, O., Luemunkong, S., & Miyazawa, T. (2011) · LWT · doi:10.1016/j.lwt.2011.09.008 · Cited by 76 · see citing works

Using historical data for bioprocess optimization: Modeling wine characteristics using artificial neural networks and archived process information

Vlassides, S., Ferrier, J. G., & Block, D. E. (2001) · Biotechnology and Bioengineering · doi:10.1002/1097-0290(20010405)73:1 · Cited by 75 · see citing works

Occurrence of Orally Administered Mulberry 1-Deoxynojirimycin in Rat Plasma

Nakagawa, K., Kubota, H., Kimura, T., Yamashita, S., Tsuzuki, T., Oikawa, S., & Miyazawa, T. (2007) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf071559m · Cited by 73 · see citing works

Treatment of hepatitis B virus-infected cells with α-glucosidase inhibitors results in production of virions with altered molecular composition and infectivity

Lazar, C., Durantel, D., Macovei, A., Zitzmann, N., Zoulim, F., Dwek, R. A., & Branza‐Nichita, N. (2007) · Antiviral Research · doi:10.1016/j.antiviral.2007.04.004 · Cited by 73 · see citing works

The structure of moranoline, a piperidine alkaloid from Morus species.

Masaaki, Y. A. G. I., Kouno, T., AOYAGI, Y., & Murai, H. (1976) · Cited by 71 · see citing works

ChemInform Abstract: Glycosidase Mechanisms: Anatomy of a Finely Tuned Catalyst

Zechel, D. L., & Withers, S. G. (2000) · ChemInform · doi:10.1002/chin.200015237 · Cited by 71 · see citing works

Moranoline (1-Deoxynojirimycin) Fermentation and Its Improvement

Ezure, Y., Maruo, S., Miyazaki, K., & Kawamata, M. (1985) · Agricultural and Biological Chemistry · doi:10.1080/00021369.1985.10866866 · Cited by 70 · see citing works

In vitro inhibition of glycogen-degrading enzymes and glycosidases by six-membered sugar mimics and their evaluation in cell cultures

Kuriyama, C., Kamiyama, O., Ikeda, K., Sanae, F., Kato, A., Adachi, I., Imahori, T., Takahata, H., Okamoto, T., & Asano, N. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.06.026 · Cited by 69 · see citing works

Glucosidase Inhibitors for Treatment of HIV-1 Infection

Ratner, L. (1992) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1992.8.165 · Cited by 68 · see citing works

Determination of iminosugars in mulberry leaves and silkworms using hydrophilic interaction chromatography–tandem mass spectrometry

Nakagawa, K., Ogawa, K., Higuchi, O., Kimura, T., Miyazawa, T., & Hori, M. (2010) · Analytical Biochemistry · doi:10.1016/j.ab.2010.05.007 · Cited by 63 · see citing works

Pharmacokinetics of acarbose. Part I: Absorption, concentration in plasma, metabolism and excretion after single administration of [14C]acarbose to rats, dogs and man.

Ahr, H. J., Boberg, M., Krause, H., Maul, W., Müller, F. O., Ploschke, H. J., Weber, H., & Wünsche, C. (1989) · PubMed · Cited by 62 · see citing works

Natural iminosugar derivatives of 1-deoxynojirimycin inhibit glycosylation of hepatitis viral envelope proteins.

Jacob, J. R., Mansfield, K. G., You, J. E., Tennant, B. C., & Kim, Y. H. (2007) · PubMed · Cited by 57 · see citing works

1-Deoxynojirimycin isolated from Bacillus subtilis improves hepatic lipid metabolism and mitochondrial function in high-fat–fed mice

Ju, H., Chung, J. H., Hwang, J. W., Kim, O. Y., Lee, J.-Y., & Shin, M. (2014) · Food and Chemical Toxicology · doi:10.1016/j.fct.2014.11.001 · Cited by 57 · see citing works

Mulberry 1-Deoxynojirimycin Inhibits Adipogenesis by Repression of the ERK/PPARγ Signaling Pathway in Porcine Intramuscular Adipocytes

Wang, G., Zhu, L., Ma, M., Chen, X., Gao, Y., Yu, T., Yang, G.-S., & Pang, W.-J. (2015) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.5b01680 · Cited by 54 · see citing works

Potentiating Effects on Pilocarpine-Induced Saliva Secretion, by Extracts and N-Containing Sugars Derived from Mulberry Leaves, in Streptozocin-Diabetic Mice.

Chen, F. J., Nakashima, N., Kimura, I., KIMURA, M., Asano, N., & Koya, S. (1995) · Biological and Pharmaceutical Bulletin · doi:10.1248/bpb.18.1676 · Cited by 53 · see citing works

Calystegine distribution in potato (Solanum tuberosum) tubers and plants

Keiner, R., & Dräger, B. (2000) · Plant Science · doi:10.1016/s0168-9452(99)00184-3 · Cited by 53 · see citing works

New cyclitols, degradation of validamycin a by Flavobacterium saccharophilum.

KANIEDA, Y., Asano, N., Teranishi, M., & Matsui, K. (1980) · The Journal of Antibiotics · doi:10.7164/antibiotics.33.1573 · Cited by 52 · see citing works

Improved 1-Deoxynojirimycin (DNJ) production in mulberry leaves fermented by microorganism

Jiang, Y.-G., Wang, C., Jin, C., Jia, J., Guo, X., Zhang, G.-Z., & Gui, Z. (2014) · Brazilian Journal of Microbiology · doi:10.1590/s1517-83822014000200048 · Cited by 46 · see citing works

Optimization of 1-Deoxynojirimycin Extraction from Mulberry Leaves by Using Response Surface Methodology

Vichasilp, C., Nakagawa, K., Sookwong, P., Suzuki, Y., Kimura, F., Higuchi, O., & Miyazawa, T. (2009) · Bioscience Biotechnology and Biochemistry · doi:10.1271/bbb.90543 · Cited by 44 · see citing works

Pharmacokinetic and pharmacodynamic interactions of morin and cyclosporin

Fang, S., Hou, Y., & Chao, P.-D. L. (2004) · Toxicology and Applied Pharmacology · doi:10.1016/j.taap.2004.09.006 · Cited by 42 · see citing works

Derivatization and Fluorescence Detection of Amino Acids and Peptides with 9-Fluorenylmethyl Chloroformate on the Surface of a Solid Adsorbent

Shangguan, D., Zhao, Y., Han, H., Zhao, R., & Liu, G. (2001) · Analytical Chemistry · doi:10.1021/ac001243c · Cited by 41 · see citing works

Trees for drylands

HOCKING, D. (1993) · Cited by 40 · see citing works

Attenuation of HIV-1 Infectivity by an Inhibitor of Oligosaccharide Processing

Dedera, D. A., Heyden, N. V., & Ratner, L. (1990) · AIDS Research and Human Retroviruses · doi:10.1089/aid.1990.6.785 · Cited by 40 · see citing works

Comparison of Absorption of 1-Deoxynojirimycin from Mulberry Water Extract in Rats

Kim, J. Y., Kwon, H. J., Jung, J. Y., Kwon, H. Y., Baek, J. G., Kim, Y.-S., & Kwon, O. (2010) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf100322y · Cited by 39 · see citing works

Inhibition by acarbose, nojirimycin and 1-deoxynojirimycin of glucosyltransferase produced by oral Streptococci

Newbrun, E., Hoover, C. I., & Walker, G. J. (1983) · Archives of Oral Biology · doi:10.1016/0003-9969(83)90186-3 · Cited by 38 · see citing works

Antiviral effects of glycosylation and glucose trimming inhibitors on human parainfluenza virus type 3

Tanaka, Y., Kato, J., Kohara, M., & Galinski, M. S. (2006) · Antiviral Research · doi:10.1016/j.antiviral.2006.03.016 · Cited by 36 · see citing works

Anti-adipogenic effect of mulberry leaf ethanol extract in 3T3-L1 adipocytes

Yang, S. J., Park, N.-Y., & Lim, Y. (2014) · Nutrition Research and Practice · doi:10.4162/nrp.2014.8.6.613 · Cited by 36 · see citing works

Effect of a Glucosidase Inhibitor On The Bioactivity And Immunoreactivity of hUman Immunodeficiency Virus Type 1 Envelope Glycoprotein

Fenouillet, E., & Jc, G. (1991) · Journal of General Virology · doi:10.1099/0022-1317-72-8-1919 · Cited by 34 · see citing works

Response Surface Optimized Extraction of 1-Deoxynojirimycin from Mulberry Leaves (Morus alba L.) and Preparative Separation with Resins

Wang, T., Li, C.-Q., Zhang, H., & Li, J.-W. (2014) · Molecules · doi:10.3390/molecules19067040 · Cited by 33 · see citing works

Adipose tissue: new therapeutic targets from molecular and genetic studies – IASO Stock Conference 2003 report

Farmer, S. R., & Auwerx, J. H. (2004) · Obesity Reviews · doi:10.1111/j.1467-789x.2004.00157.x · Cited by 32 · see citing works

Anti-HIV drug mechanism

Jones, I. M., & Jacob, G. S. (1991) · Nature · doi:10.1038/352198b0 · Cited by 31 · see citing works

Enhancement of 1-deoxynojirimycin content and α-glucosidase inhibitory activity in mulberry leaf using various fermenting microorganisms isolated from Korean traditional fermented food

Jeong, J. H., Lee, N. K., Cho, S. H., Jeong, D., & Jeong, Y. (2014) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-014-0277-0 · Cited by 31 · see citing works

Distribution and Elimination of the Glycosidase Inhibitors 1-Deoxymannojirimycin and N-Methyl-1-Deoxynojirimycin in the Rat in Vivo

Faber, E. D., Oosting, R., Neefjes, J., Ploegh, H. L., & Meijer, D. K. F. (1992) · Pharmaceutical Research · doi:10.1023/a:1015810913257 · Cited by 29 · see citing works

1-Deoxynojirimycin Isolated from a Bacillus subtilis Stimulates Adiponectin and GLUT4 Expressions in 3T3-L1 Adipocytes

Lee, S. M. (2013) · Journal of Microbiology and Biotechnology · doi:10.4014/jmb.1209.09043 · Cited by 29 · see citing works

Determination of vitamins in food-matrix Standard Reference Materials

Sharpless, K. E., Margolis, S. A., & Thomas, J. B. (2000) · Journal of Chromatography A · doi:10.1016/s0021-9673(00)00260-0 · Cited by 28 · see citing works

Les Iminosucres : applications thérapeutiques actuelles et futures

Martin, O. R. (2007) · Annales Pharmaceutiques Françaises · doi:10.1016/s0003-4509(07)90013-9 · Cited by 27 · see citing works

Simple, Selective, and Rapid Quantification of 1‐Deoxynojirimycin in Mulberry Leaf Products by High‐Performance Anion‐Exchange Chromatography with Pulsed Amperometric Detection

Yoshihashi, T., Do, H. T. T., Tungtrakul, P., Boonbumrung, S., & Yamaki, K. (2010) · Journal of Food Science · doi:10.1111/j.1750-3841.2010.01528.x · Cited by 25 · see citing works

Comparative safety of newer oral antidiabetic drugs

Krentz, A. J. (2006) · Expert Opinion on Drug Safety · doi:10.1517/14740338.5.6.827 · Cited by 24 · see citing works

Liquid Chromatographic Tandem Mass Spectrometry Method for the Quantification of Miglitol in Human Plasma

Nirogi, R. V. S., Kandikere, V. N., Shukla, M., Mudigonda, K., Maurya, S., Boosi, R., & Anjaneyulu, Y. (2011) · Arzneimittelforschung · doi:10.1055/s-0031-1296730 · Cited by 23 · see citing works

Glycosidase inhibition by novel guanidinium and urea iminosugar derivatives

Kooij, R., Branderhorst, H. M., Bonte, S., Wieclawska, S. M., Martin, N. I., & Pieters, R. J. (2012) · MedChemComm · doi:10.1039/c2md20343j · Cited by 22 · see citing works

Derivatization of tertiary amphetamines with 9-fluorenylmethyl chloroformate for liquid chromatography: determination of N-methylephedrine

Herráez-Hernández, R., & Campíns-Falcó, P. (2000) · The Analyst · doi:10.1039/b002138p · Cited by 15 · see citing works

Analysis of human β-endorphin 28–31 (melanotropin potentiating factor) and analogues by high-performance liquid chromatography of their 9-fluorenylmethoxy-carbonyl derivatives

Lewis, J. R., Morley, J. S., & Venn, R. F. (1993) · Journal of Chromatography B Biomedical Sciences and Applications · doi:10.1016/0378-4347(93)80288-f · Cited by 12 · see citing works

Analysis of 1-deoxynojirimycin component correlation between medicinal parasitic loranthus from loranthaceae and their mulberry host trees

Hu, K., Li‐Beisson, Y., Yukai, D., Su, B., & Dong, L. (2011) · Journal of Medicinal Plants Research · doi:10.5897/jmpr.9000077 · Cited by 11 · see citing works

Carboxymethylcellulose sodium improves the pharmacodynamics of 1-deoxynojirimycin by changing its absorption characteristics and pharmacokinetics in rats

Wang, L., Peng, J., Wang, X., Zhu, X., Cheng, B., Gao, J., Jiang, M., Bai, G., & Hou, Y. (2012) · Die Pharmazie · doi:10.31083/ph.2012.1106 · Cited by 8 · see citing works

Quantitative determination of 1-Deoxynojirimycin in different Mulberry Varieties of India

Bajpai, S., & Rao, A. V. B. (2014) · Journal of Pharmacognosy and Phytochemistry · Cited by 8 · see citing works

Effect of silkworm powder (SP) lowering blood-glucose levels in mice and its mechanism

Gui, Z., Dahuan, Z., Chen, J., & Chen, W. (2001) · Canye kexue · Cited by 7 · see citing works

Glucose Supply and Insulin Demand Dynamics of Antidiabetic Agents

Monte, S. V., Schentag, J. J., Adelman, M. H., & Paladino, J. A. (2010) · Journal of Diabetes Science and Technology · doi:10.1177/193229681000400219 · Cited by 5 · see citing works

Gaucher disease: improving management

Bembi, B., & Deegan, P. B. (2008) · Acta Paediatrica · doi:10.1111/j.1651-2227.2008.00643.x · Cited by 4 · see citing works

Effect of 1-deoxynojirimycin on the Replication of Baculoviruses, Bombyx Mori Nucleopolyhedrovirus and Autographa Californica Multiple Nucleopolyhedrovirus

Kang, K., Park, J.-S., Cho, Y., Park, Y. S., Lee, J., Hwang, K.-Y., Yuk, W.-J., Kamita, S. G., Suzuki, K., & Seong, S. (2011) · International Journal of Industrial Entomology · doi:10.7852/ijie.2011.23.1.123 · Cited by 3 · see citing works

Recent Advances in the Total Synthesis of Piperidine Azasugars

Pearson-Long, M. S. M., Mathé‐Allainmat, M., Fargeas, V., & Lebreton, J. (2005) · ChemInform · doi:10.1002/chin.200536239 · Cited by 2 · see citing works

Natural product-derived compounds in clinical trials and drug approvals

Butler, M. S., Capon, R. J., Blaskovich, M. A. T., & Henderson, I. R. (2025) · Natural Product Reports · doi:10.1039/d5np00031a · Cited by 77 · see citing works

Efficacy and Safety of Mulberry Twig Alkaloids Tablet for the Treatment of Type 2 Diabetes: A Multicenter, Randomized, Double-Blind, Double-Dummy, and Parallel Controlled Clinical Trial

Qu, L., Liang, X., Tian, G., Zhang, G., Wu, Q., Huang, X., Cui, Y., Liu, Y., Shen, Z., Xiao, C., et al. (2021) · Diabetes Care · doi:10.2337/dc20-2109 · Cited by 72 · see citing works

A randomized controlled study of dose-finding, efficacy, and safety of mulberry leaves on glycemic profiles in obese persons with borderline diabetes

Thaipitakwong, T., Supasyndh, O., Rasmi, Y., & Aramwit, P. (2019) · Complementary Therapies in Medicine · doi:10.1016/j.ctim.2019.102292 · Cited by 67 · see citing works

An overview of the biological production of 1-deoxynojirimycin: current status and future perspective

Zhang, W., Mu, W., Wu, H., & Liang, Z. (2019) · Applied Microbiology and Biotechnology · doi:10.1007/s00253-019-10191-9 · Cited by 61 · see citing works

Safety evaluation of mulberry leaf extract: Acute, subacute toxicity and genotoxicity studies

Li, Y., Zhang, X., Liang, C., Hu, J., & Yu, Z. (2018) · Regulatory Toxicology and Pharmacology · doi:10.1016/j.yrtph.2018.03.007 · Cited by 60 · see citing works

1-Deoxynojirimycin, its potential for management of non-communicable metabolic diseases

Thakur, K., Zhang, Y., Mocan, A., Zhang, F., Zhang, J., & Wei, Z. (2019) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2019.05.010 · Cited by 48 · see citing works

A comprehensive review on the production, pharmacokinetics and health benefits of mulberry leaf iminosugars: Main focus on 1-deoxynojirimycin, d-fagomine, and 2-O-ɑ-d-galactopyranosyl-DNJ

Parida, I. S., Takasu, S., & Nakagawa, K. (2021) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2021.1989660 · Cited by 42 · see citing works

1-Deoxynojirimycin attenuates septic cardiomyopathy by regulating oxidative stress, apoptosis, and inflammation via the JAK2/STAT6 signaling pathway

Jiang, L., Zhang, L., Yang, J., Shi, H., Zhu, H., Zhai, M., Lu, L., Wang, X., Li, X. Y., Yu, S., et al. (2022) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2022.113648 · Cited by 40 · see citing works

Mulberry leaf extract reduces the glycemic indexes of four common dietary carbohydrates

Wang, R., Li, Y., Mu, W., Li, Z., Sun, J., Wang, B., Zhong, Z., Luo, X., Xie, C., & Huang, Y. (2018) · Medicine · doi:10.1097/md.0000000000011996 · Cited by 40 · see citing works

1-Deoxynojirimycin improves high fat diet-induced nonalcoholic steatohepatitis by restoring gut dysbiosis

Zheng, J., Zhu, L., Hu, B., Zou, X., Hu, H., Zhang, Z., Jiang, N., Ma, J., Yang, H., & Liu, H. (2019) · The Journal of Nutritional Biochemistry · doi:10.1016/j.jnutbio.2019.05.013 · Cited by 40 · see citing works

Effect of a dietary inclusion of full-fat or defatted silkworm pupa meal on the nutrient digestibility and faecal microbiome of fattening quails

Zotte, A. D., Singh, Y., Squartini, A., Stevanato, P., Cappellozza, S., Kovitvadhi, A., Subaneg, S., Bertelli, D., & Cullere, M. (2021) · animal · doi:10.1016/j.animal.2020.100112 · Cited by 39 · see citing works

Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities, Molecular Docking, and Antioxidant Capacities of Plectranthus ecklonii Constituents

Etsassala, N. G. E. R., Badmus, J. A., Marnewick, J. L., Egieyeh, S. A., Iwuoha, E. I., Nchu, F., & Hussein, A. A. (2022) · Antioxidants · doi:10.3390/antiox11020378 · Cited by 36 · see citing works

1-Deoxynojirimycin from Bacillus subtilis improves antioxidant and antibacterial activities of juvenile Yoshitomi tilapia

Tang, L., Huang, K., Xie, J., Yu, D., Sun, L., Huang, Q. Y., & Bi, Y. (2017) · Electronic Journal of Biotechnology · doi:10.1016/j.ejbt.2017.08.006 · Cited by 35 · see citing works

Synthesis and Therapeutic Applications of Iminosugars in Cystic Fibrosis

Esposito, A., D’Alonzo, D., Fenza, M. D., Gregorio, E. D., Tamanini, A., Lippi, G., Dechecchi, M. C., & Guaragna, A. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21093353 · Cited by 33 · see citing works

Iminosugars: Effects of Stereochemistry, Ring Size, and N-Substituents on Glucosidase Activities

Zamoner, L. O. B., Aragão-Leoneti, V., & Carvalho, I. (2019) · Pharmaceuticals · doi:10.3390/ph12030108 · Cited by 32 · see citing works

Effects of dietary mulberry leaf extract on the growth, gastrointestinal, hepatic functions of Chinese giant salamander ( Andrias davidianus )

Li, Z., Chen, X., Chen, Y., Li, W., Feng, Q., Zhang, H., Huang, X., & Luo, L. (2020) · Aquaculture Research · doi:10.1111/are.14639 · Cited by 29 · see citing works

Enhanced Production of 1-Deoxynojirimycin in Bacillus subtilis subsp. inaquosorum by Random Mutagenesis and Culture Optimization

Nguyen, K. N., Kim, Y., Maibunkaew, S., Park, J., Nguyen, M. T., Oh, D., & Kwon, O. (2021) · Biotechnology and Bioprocess Engineering · doi:10.1007/s12257-020-0231-2 · Cited by 29 · see citing works

Nitro-substituted tetrahydroindolizines and homologs: Design, kinetics, and mechanism of α-glucosidase inhibition

Tavani, C., Bianchi, L., Palma, A. D., Passeri, G. I., Punzi, G., Pierri, C. L., Lovece, A., Cavalluzzi, M. M., Franchini, C., Lentini, G., et al. (2017) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2017.07.068 · Cited by 27 · see citing works

Purification, identification and in silico models of alkaloids from Nardostachys jatamansi — bioactive compounds for neurodegenerative diseases

Krishnan, N., Vairamani, M., Dhanabalan, A. K., Velmurugan, D., Gopinath, S. C. B., & Pachaiappan, R. (2022) · Biomass Conversion and Biorefinery · doi:10.1007/s13399-022-03237-y · Cited by 27 · see citing works

Morus Alba leaf extract affects metabolic profiles, biomarkers inflammation and oxidative stress in patients with type 2 diabetes mellitus: A double-blind clinical trial

Taghizadeh, M., Zadeh, A. M., Asemi, Z., Farrokhnezhad, A. H., Memarzadeh, M. R., Banikazemi, Z., Shariat, M., & Shafabakhsh, R. (2022) · Clinical Nutrition ESPEN · doi:10.1016/j.clnesp.2022.03.027 · Cited by 25 · see citing works

In Vitro Alpha-Glucosidase and Alpha-Amylase Inhibitory Activities and Antioxidant Capacity of Helichrysum cymosum and Helichrysum pandurifolium Schrank Constituents

Jadalla, B. M. I. S., Moser, J., Sharma, R. K., Etsassala, N. G. E. R., Egieyeh, S. A., Badmus, J. A., Marnewick, J. L., Beukes, D. R., Cupido, C. N., & Hussein, A. A. (2022) · Separations · doi:10.3390/separations9080190 · Cited by 25 · see citing works

Dihydroquinazolin-4(1H)-one derivatives as novel and potential leads for diabetic management

Babatunde, O., Hameed, S., Salar, U., Chigurupati, S., Wadood, A., Rehman, A. U., Venugopal, V., Khan, K. M., Taha, M., & Perveen, S. (2021) · Molecular Diversity · doi:10.1007/s11030-021-10196-5 · Cited by 24 · see citing works

Mulberry-Derived 1-Deoxynojirimycin Prevents Type 2 Diabetes Mellitus Progression via Modulation of Retinol-Binding Protein 4 and Haptoglobin

Fongsodsri, K., Thaipitakwong, T., Rujimongkon, K., Kanjanapruthipong, T., Ampawong, S., Reamtong, O., & Aramwit, P. (2022) · Nutrients · doi:10.3390/nu14214538 · Cited by 25 · see citing works

Integrated in vitro, in silico, and in vivo approaches to elucidate the antidiabetic mechanisms of Cicer arietinum and Hordeum vulgare extract and secondary metabolites

Shahzad, A., Liu, W., Hussain, S., Ni, Y., Cui, K., Sun, Y., Liu, X., Duan, Q., Xia, J., Zhang, J., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-89642-5 · Cited by 22 · see citing works

Mulberry 1-deoxynojirimycin (DNJ): an exemplary compound for therapeutics

Venkatesh Kumar, R., Srivastava, D., Singh, P., Kumar, U., & Singh, V. (2020) · The Journal of Horticultural Science and Biotechnology · doi:10.1080/14620316.2020.1760738 · Cited by 22 · see citing works

Submerged fermentation improves bioactivity of mulberry fruits and leaves

Chuah, H. Q., Tang, P. L., Ang, N. J., & Tan, H. Y. (2021) · Chinese Herbal Medicines · doi:10.1016/j.chmed.2021.09.003 · Cited by 21 · see citing works

Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives

Lu, T.-T., Shimadate, Y., Cheng, B., Kanekiyo, U., Kato, A., Wang, J.-Z., Li, Y., Jia, Y., Fleet, G. W. J., & Yu, C. (2021) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2021.113716 · Cited by 20 · see citing works

GANAB and N-Glycans Substrates Are Relevant in Human Physiology, Polycystic Pathology and Multiple Sclerosis: A Review

De Masi, R., & Orlando, S. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms23137373 · Cited by 20 · see citing works

Strategies for the Asymmetric Construction of Pelletierine and its Use in the Synthesis of Sedridine, Myrtine, and Lasubine

Zaidan, R. K., & Evans, P. (2019) · European Journal of Organic Chemistry · doi:10.1002/ejoc.201900477 · Cited by 19 · see citing works

Comparative genomic analysis of azasugar biosynthesis

Beal, H. E., & Horenstein, N. A. (2021) · AMB Express · doi:10.1186/s13568-021-01279-5 · Cited by 19 · see citing works

Analysis of White Mulberry Leaves and Dietary Supplements, ATR-FTIR Combined with Chemometrics for the Rapid Determination of 1-Deoxynojirimycin

Walkowiak, A., Piekuś-Słomka, N., Wnuk, K., & Kupcewicz, B. (2022) · Nutrients · doi:10.3390/nu14245276 · Cited by 18 · see citing works

Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review

Tricase, A. F., Cavalluzzi, M. M., Catalano, A. A., Bellis, M. D., Palma, A. D., Basile, G., Sinicropi, M. S., & Lentini, G. (2025) · Molecules · doi:10.3390/molecules30153213 · Cited by 15 · see citing works

Efficacy and Safety of Mulberry Twig Alkaloids Tablet for Treatment of Type 2 Diabetes: A Randomized, Double-Blind, Placebo-Controlled Multicenter Clinical Study

Qu, L., Liang, X., Tian, G., Zhang, G.-L., Wu, Q., Huang, X., Cui, Y., Liu, Y., Shen, Z., Ma, G., et al. (2022) · Chinese Journal of Integrative Medicine · doi:10.1007/s11655-021-2885-9 · Cited by 15 · see citing works

The use of Bagassa guianensis aubl. forestry waste as an alternative for obtaining bioproducts and bioactive compounds

Pinheiro, W. B. D. S., Neto, J. R. P., Botelho, A. S., dos Santos, K. I. P., da Silva, G. A., Muribeca, A. D. J. B., Pamplona, S. D. G. S. R., Fonseca, S. S. S., Silva, M. N., & Arruda, M. S. P. (2022) · Arabian Journal of Chemistry · doi:10.1016/j.arabjc.2022.103813 · Cited by 14 · see citing works

The Effects of 1-Deoxynojirimycin from Mulberry on Oxidative Stress and Inflammation in Laying Hens and the Direct Effects on Intestine Epithelium Cells In Vitro

Wang, M., Feng, Y., Li, T., Zhao, C., Barcenas, A. R., Serrano, B. R., Qu, L., Shen, M., & Zhao, W. (2023) · Animals · doi:10.3390/ani13182830 · Cited by 14 · see citing works

Quantitative determination of 1-deoxynojirimycin in 146 varieties of mulberry fruit

Wang, Z., Dai, F., Tang, C., Xiao, G., Li, Z., & Luo, G. (2021) · International Journal of Food Properties · doi:10.1080/10942912.2021.1955923 · Cited by 14 · see citing works

Orthoester functionalized N -guanidino derivatives of 1,5-dideoxy-1,5-imino- d -xylitol as pH-responsive inhibitors of β-glucocerebrosidase

Sevšek, A., Toraño, J. S., van Ufford, L. Q., Moret, E. E., Pieters, R. J., & Martin, N. I. (2017) · MedChemComm · doi:10.1039/c7md00480j · Cited by 12 · see citing works

Profiling of Secondary Metabolites of Optimized Ripe Ajwa Date Pulp (Phoenix dactylifera L.) Using Response Surface Methodology and Artificial Neural Network

Alshammari, F. H., Alam, M. B., Naznin, M., Javed, A., Kim, S., & Lee, S. (2023) · Pharmaceuticals · doi:10.3390/ph16020319 · Cited by 12 · see citing works

Tear and Saliva Metabolomics in Evaporative Dry Eye Disease in Females

Fineide, F. A., Tashbayev, B., Elgstøen, K. B. P., Sandås, E. M., Rootwelt, H., Hynne, H., Chen, X., Ræder, S., Vehof, J., Dartt, D. A., et al. (2023) · Metabolites · doi:10.3390/metabo13111125 · Cited by 11 · see citing works

Safety assessment of a standardized cucumber extract (Q-Actin™): Oral repeat-dose toxicity and mutagenicity studies

Kothari, S. C., Saravana, M., Muthusamy, S., Mozingo, A., & Soni, M. G. (2018) · Toxicology Reports · doi:10.1016/j.toxrep.2018.10.014 · Cited by 11 · see citing works

Mining and characterization of a novel cytochrome P450 MaCYP71BG22 involved in the C4-stereoselective hydroxylation of 1-deoxynojirimycin biosynthesis in mulberry leaves

Liao, Y., Wu, M. C., Fan, J., Wan, J., An, X., Li, X., Wei, Y., & Ouyang, Z. (2024) · International Journal of Biological Macromolecules · doi:10.1016/j.ijbiomac.2024.136941 · Cited by 10 · see citing works

Schiff Bases From 4‐Aminoantipyrine: Investigation of Their In Silico, Antimicrobial, and Anticancer Effects and Their Use in Glucose Biosensor Design

Erbaş, A., Dikim, S., Arslan, F., Bodur, O. C., Arslan, S., Özdemir, F., & Sarı, N. (2025) · Bioinorganic Chemistry and Applications · doi:10.1155/bca/2786064 · Cited by 10 · see citing works

Studies on 1-deoxynojirimycin biosynthesis in mulberry ( Morus alba L.) seeds through comparative transcriptomics

Xin, X., Jiang, X., Attaribo, T., Niu, B., Zhang, M., Xu, X., Zhang, R., Li, H., & Gui, Z. (2023) · Natural Product Research · doi:10.1080/14786419.2023.2190114 · Cited by 10 · see citing works

Dietary inclusion of defatted silkworm (Bombyx mori L.) pupa meal in broiler chickens: phase feeding effects on nutritional and sensory meat quality

Zotte, A. D., Singh, Y., Zsédely, E., Contiero, B., Palumbo, B., & Cullere, M. (2024) · Poultry Science · doi:10.1016/j.psj.2024.103812 · Cited by 9 · see citing works

Expanding horizons of iminosugars as broad-spectrum anti-virals: mechanism, efficacy and novel developments

Liu, Q., Liu, Y., Liu, T., Fan, J., Xia, Z., Zhou, Y., & Deng, X. (2024) · Natural Products and Bioprospecting · doi:10.1007/s13659-024-00477-5 · Cited by 9 · see citing works

Suppression of N-glycan processing enzymes by deoxynojirimycin in tomato (Solanum lycopersicum) fruit

Dorairaj, D., Puthusseri, B., & Shetty, N. P. (2020) · 3 Biotech · doi:10.1007/s13205-020-02196-3 · Cited by 9 · see citing works

Stereoselective Access to Iminosugar C , C ‑Glycosides from 6‑Azidoketopyranoses

Debbah, Z., Marrot, J., Auberger, N., Désiré, J., & Blériot, Y. (2022) · Organic Letters · doi:10.1021/acs.orglett.2c01560 · Cited by 9 · see citing works

α-Glucosidase inhibitors as broad-spectrum antivirals: Current knowledge and future prospects

Kang, J. W., Chan, K. W. K., Vasudevan, S. G., & Low, J. G. H. (2025) · Antiviral Research · doi:10.1016/j.antiviral.2025.106147 · Cited by 8 · see citing works

Evaluation of Nonnatural L-Iminosugar C,C-Glycosides, a New Class of C-Branched Iminosugars, as Glycosidase Inhibitors

Désiré, J., Debbah, Z., Gueyrard, D., Marrot, J., Blériot, Y., & Kato, A. (2023) · Carbohydrate Research · doi:10.1016/j.carres.2023.108903 · Cited by 8 · see citing works

Advances in the Extraction, Purification and Detection of the Natural Product 1-Deoxynojirimycin

Hong, K., Fu, X., Yin, H., Li, S.-T., Chen, T., & Wang, Z. (2020) · Critical Reviews in Analytical Chemistry · doi:10.1080/10408347.2019.1711012 · Cited by 8 · see citing works

Sangguayin preparation prevents palmitate-induced apoptosis by suppressing endoplasmic reticulum stress and autophagy in db/db mice and MIN6 pancreatic β-cells

Xing, Q., Liu, X., Li, W., Chen, Y., & Chen, J. (2020) · Chinese Journal of Natural Medicines · doi:10.1016/s1875-5364(20)30054-6 · Cited by 8 · see citing works

Efficient One-Pot Synthesis of Arylated Pyrazole-Fused Pyran Analogs: As Leads to Treating Diabetes and Alzheimer's Disease

Hameed, S., Babatunde, O., Salar, U., Jabbar, A., Chigurupati, S., Solangi, M., Atta, L., Ul‐Haq, Z., Saleem, F., Bhatia, S., et al. (2022) · Future Medicinal Chemistry · doi:10.4155/fmc-2022-0103 · Cited by 8 · see citing works

Asymmetric syntheses of fagomine and its stereoisomers

Davies, S. G., Fletcher, A. M., Roberts, P. M., & Thomson, J. E. (2019) · Tetrahedron · doi:10.1016/j.tet.2019.130727 · Cited by 8 · see citing works

Synthesis and novel structural hybrid analogs of oxindole derivatives bearing piperidine ring, their antidiabetics II activity and molecular docking study

Mukhliss, L., Taha, M., Rahim, F., Adalat, B., Ajmal, A., Wadood, A., Uddin, N., Khan, K. M., & Shah, S. A. A. (2025) · Journal of Molecular Structure · doi:10.1016/j.molstruc.2025.141666 · Cited by 7 · see citing works

Identification of novel triazolopyrimidines as potent α-glucosidase inhibitor through design, synthesis, biological evaluations, and computational analysis

Peytam, F., Norouzbahari, M., Gülcan, H. O., Hosseini, F. S., Moghadam, M. S., Mojtabavi, S., Faramarzi, M. A., Ghasemi, F., Torabi, M., Sadat-Ebrahimi, S. E., et al. (2025) · Scientific Reports · doi:10.1038/s41598-025-23387-z · Cited by 7 · see citing works

Synthesis and Evaluation of Phenyltriazole-Deoxynojirimycin Hybrids as Potent α-Glucosidase Inhibitors

Wang, L., Luo, W. D., Zhao, Y., Guo, X., Bai, X., Guo, L., & Zhu, N. (2024) · Molecules · doi:10.3390/molecules29215062 · Cited by 7 · see citing works

Developments in Carbohydrate-Based Metzincin Inhibitors

Cuffaro, D., Nuti, E., D’Andrea, F., & Rossello, A. (2020) · Pharmaceuticals · doi:10.3390/ph13110376 · Cited by 7 · see citing works

N-(1-Phenylethyl)aziridine-2-carboxylate esters in the synthesis of biologically relevant compounds

Głowacka, I. E., Trocha, A., Wróblewski, A. E., & Piotrowska, D. G. (2019) · Beilstein Journal of Organic Chemistry · doi:10.3762/bjoc.15.168 · Cited by 7 · see citing works

Effect of mulberry fruit extract on post-prandial glycaemic and insulinemic responses to different rice types: a randomised trial in healthy adults

Mela, D. J., Boers, H. M., Kadam, T., Hiemstra, H., Kalathil, R., & ten Hoorn, J. W. M. S. (2023) · British Journal Of Nutrition · doi:10.1017/s0007114523001319 · Cited by 6 · see citing works

Traditional Herbal Products Used for the Management of Diabetes in Croatia: Linking Traditional Use With α-Glucosidase-Inhibitory Activity

Končić, M. Z., & Bljajić, K. (2019) · Elsevier eBooks · doi:10.1016/b978-0-12-813822-9.00042-4 · Cited by 6 · see citing works

The case for re-examining glycosylation inhibitors, mimetics, primers and glycosylation decoys as antivirals and anti-inflammatories in COVID19

Laine, R. A. (2020) · Glycobiology · doi:10.1093/glycob/cwaa083 · Cited by 6 · see citing works

Alginate-Based Carriers Loaded with Mulberry (Morus alba L.) Leaf Extract: A Promising Strategy for Prolonging 1-Deoxynojirimicyn (DNJ) Systemic Activity for the Nutraceutical Management of Hyperglycemic Conditions

Marchetti, L., Truzzi, E., Rossi, M. C., Benvenuti, S., Cappellozza, S., Saviane, A., Bogataj, L., Siligardi, C., & Bertelli, D. (2024) · Molecules · doi:10.3390/molecules29040797 · Cited by 5 · see citing works

Effect of Low-Dose Mulberry Fruit Extract on Postprandial Glucose and Insulin Responses: A Randomized Pilot Trial in Individuals with Type 2 Diabetes

Mela, D. J., Alssema, M., Hiemstra, H., Hoogenraad, A.-R., & Kadam, T. (2024) · Nutrients · doi:10.3390/nu16142177 · Cited by 5 · see citing works

Preparation of 1-deoxynojirimycin controlled release matrix pellets of capsules and evaluation in vitro-in vivo to enhance bioavailability

Sun, Z., Zhao, H., & Liu, Z. (2019) · Journal of Drug Delivery Science and Technology · doi:10.1016/j.jddst.2019.05.015 · Cited by 5 · see citing works

Enhancement of iminosugar production, 1-deoxynojirimycin and 1-deoxymannojirimycin, in recombinant Corynebacterium glutamicum

Siziya, I. N., Lim, H. J., Jung, D.-H., Baek, S., Lee, S. G., & Seo, M. (2025) · Food Science and Biotechnology · doi:10.1007/s10068-025-01834-x · Cited by 4 · see citing works

Pb contaminated soil influence on aboveground biomass and bioactive compounds in leaves of mulberry

Wang, L., Wang, N., & Ji, G. (2021) · International Journal of Phytoremediation · doi:10.1080/15226514.2021.2002808 · Cited by 4 · see citing works

Chemometric evaluation of functional components and anti‐quorum sensing activity of mulberry leaves from Indian cultivars: a potential contribution to the food industry

Shreelakshmi, S. V., Nazareth, M. S., Pradeep, M., Dorairaj, D., & Shetty, N. P. (2021) · Journal of the Science of Food and Agriculture · doi:10.1002/jsfa.11385 · Cited by 4 · see citing works

Disperse Solid-Phase Extraction Cleanup for the Determination of 1-Deoxynojirimycin in Mulberry Leaves with Ultraperformance Liquid Chromatography-Tandem Mass Spectrometry

Zhang, L., Zhou, Y., Meng, J., & Li, J. (2021) · Journal of Food Quality · doi:10.1155/2021/2274450 · Cited by 3 · see citing works

Evaluation and development of a novel pre-treatment method for mulberry leaves to enhance their bioactivity via enzymatic degradation of GAL-DNJ to DNJ

Takasu, S., Parida, I. S., Kojima, Y., Kimura, T., & Nakagawa, K. (2021) · Food & Function · doi:10.1039/d1fo02307a · Cited by 3 · see citing works

The influence of ambient temperature and polyphenols from plant leaves on growth and the response to oxidative and nitrosative stress in African nightcrawler earthworm, Eudrilus eugeniae (Kinberg, 1867)

Ponsen, S., Wongchantra, P., & Aengwanich, W. (2023) · International Journal of Biometeorology · doi:10.1007/s00484-023-02448-w · Cited by 3 · see citing works

Golgi α-mannosidases regulate cell surface N-glycan type and ectodomain shedding of the transmembrane protease corin

Wang, H., Liu, Y., Peng, Y., Chen, W., Dong, N., Wu, Q., Pan, B., Wang, B., & Guo, W. (2023) · Journal of Biological Chemistry · doi:10.1016/j.jbc.2023.105211 · Cited by 3 · see citing works

Synthesis of a di-O-acylated deoxynojirimycin (DNJ) derivative and evaluation of its antibacterial and antibiofilm activity against Staphylococcus aureus and Stenotrophomonas maltophilia

Esposito, A., D’Alonzo, D., Stabile, M. R., Firpo, V., Migliaccio, A., Artiano, R., D’Errico, S., Gregorio, E. D., & Guaragna, A. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109379 · Cited by 3 · see citing works

Glucosidase Inhibition to Study Calnexin-assisted Glycoprotein Folding in Cells

Wang, H., & Wu, Q. (2019) · BIO-PROTOCOL · doi:10.21769/bioprotoc.3248 · Cited by 3 · see citing works

Novel DNJ Derivative Ameliorates Cardiac Hypertrophy by Targeting OPA1 and Restoring Mitochondrial Health

Ding, X., Jiang, Y., Wang, X., Li, C., Kong, Z., Fu, L., Lei, Z., Cai, H., Dong, Y., Shi, C., et al. (2025) · Circulation Research · doi:10.1161/circresaha.125.327407 · Cited by 2 · see citing works

Polyphenolic Profiles and Cytotoxic Effect of Iraqi Morus alba leaves Ethyl Acetate Extract.

Ibrahim, R. M., Nabaa, M. I., & Abdul-jalil, T. Z. (2023) · Biomedical & Pharmacology Journal · doi:10.13005/bpj/2624 · Cited by 2 · see citing works

TCM theory-inspired discovery of DNJ-flavonoid conjugates as broad-spectrum anti-SARS-CoV-2 agents by primarily targeting ER-associated glycoprotein folding process

Liu, Y., Li, Z., Zhou, Y.-Z., Wang, S., Chen, Z.-P., Liu, S.-X., Zhan, P., Zhou, Y., Xia, Z., & Deng, X. (2025) · European Journal of Medicinal Chemistry · doi:10.1016/j.ejmech.2025.117582 · Cited by 1 · see citing works

Effect of fibroin-based edible coatings enriched with mulberry leaf extract on postharvest quality and bioactive properties of table grapes

Demirel, F. T. K., Şahan, Y., & Dağdelen, A. F. (2026) · Journal of Food Measurement & Characterization · doi:10.1007/s11694-026-04527-z · Cited by 1 · see citing works

Integrative GC – MS , FT ‐ IR , and Molecular Docking Analysis of Drimycarpus racemosus (Roxb.) Hook.f ex Marchand: In Vivo Analgesic and Antidiabetic Potential

Ali, M. S., Islam, M. R., M.A.Rafi, Esha, S. H., Hasan, M. M., Hossain, P., Ripon, A., & Sultana, N. (2026) · Food Science & Nutrition · doi:10.1002/fsn3.72204 · Cited by 1 · see citing works

Exploring the Biodiversity and Anticancer Potential of Fungal Endophytes from Peronema canescens Jack

Triastuti, A., Amalia, S. P., Ilyas, M. H., Pramisandi, A., Wardana, A. W., Lubis, R. A., Julianto, T. S., Rachmawaty, F. J., & Sukmarini, L. (2025) · Chemistry & Biodiversity · doi:10.1002/cbdv.202403347 · Cited by 1 · see citing works

Caffeic Acid Phenethyl Ester Effects: In Silico Study of its Osteoimmunological Mechanisms

Zhao, Y., Pang, X., Nepal, A., Jiang, X., Xu, X., Zhao, D., Murtaza, G., & Ma, Y. (2018) · Letters in Drug Design & Discovery · doi:10.2174/1570180815666180803111902 · Cited by 1 · see citing works

Chemical synthesis and preliminary biological evaluation of C-6- O -methyl-1-deoxynojirimycin as a potent α-glucosidase inhibitor

Wang, L., Liang, T., & Fang, Z. (2019) · Journal of Carbohydrate Chemistry · doi:10.1080/07328303.2019.1700995 · Cited by 1 · see citing works

Iminosugar 1-Deoxynojirimycin (DNJ) sebagai Antiviral Infeksi Virus Dengue

Adnan, M. (2020) · KELUWIH Jurnal Kesehatan dan Kedokteran · doi:10.24123/kesdok.v2i1.2970 · Cited by 1 · see citing works

Simple Determination of 1-Deoxynojirimycin in a New Dietary Supplement by Liquid Chromatography

Themelis, T., Boschetti, S., Gelli, M., & Gatti, R. (2018) · Chromatographia · doi:10.1007/s10337-018-3609-y

α-GLUCOSIDASE INHIBITION OF LACTONE INTERMEDIATES OF THE IMINOSUGAR DEOXYNOJIRIMYCIN

Haan, Y. W., Al-Bajalan, H. M., Sage, E. E., Elangovan, D., Yajit, N. L. M., Sarizan, N. M., Zitzmann, N., Kiappes, J. L., Hasbullah, S. A., Ismail, N. H., et al. (2019) · Jurnal Teknologi · doi:10.11113/jt.v81.13079

Efficacy and safety of mulberry leaves on glycemic control in patients with obesity and patients with type 2 diabetes

Thaipitakwong, T. (2020) · doi:10.58837/chula.the.2020.367

ERI SILKWORM PUPAE MEAL AS A FISH MEAL REPLACEMENT IN JAPANESE QUAIL STARTER DIET

Gokulakrishnaa, R. K., Selvamuthukumaran, T., & Kothandaraman, S. (2025) · The Journal of Animal and Plant Sciences · doi:10.36899/japs.2025.1.0022

Petasis-mediated exo-iminoglycals synthesis from glyconolactams allows access to unprecedented 1-spirocyclopropyl deoxynojirimycin

Chopin, L., Beato, A., Yorga, D., Auberger, N., Behr, J., Désiré, J., & Blériot, Y. (2025) · Carbohydrate Research · doi:10.1016/j.carres.2025.109765

Additional file 1 of Comparative genomic analysis of azasugar biosynthesis

Beal, H. E., & Horenstein, N. A. (2021) · Figshare · doi:10.6084/m9.figshare.16417646

Advancements on the alleviation of sepsis through alkaloids derived from plants: From the past to the current

Wu, R., Liu, S., Ran, Y., Jin, Z., Qin, M., He, Y., & Liu, H. (2026) · Fitoterapia · doi:10.1016/j.fitote.2026.107401

Microbial fermentation of medicine-food homology plants for type 2 diabetes mellitus intervention: From molecular structural remodeling to gut-host metabolic crosstalk

Ma, X., Zhu, P., Yan, K., Fan, L., Luo, A., & Li, J. (2026) · Food Bioscience · doi:10.1016/j.fbio.2026.109847

BindingDB Entry 50014230: Synthesis and glycosidase inhibition of 5-C-alkyl-DNJ and 5-C-alkyl-l-ido-DNJ derivatives.

BindingDB (2022) · UC San Diego · doi:10.7270/q27w6h1p

BindingDB Entry 50023805: TCM theory-inspired discovery of DNJ-flavonoid conjugates as broad-spectrum anti-SARS-CoV-2 agents by primarily targeting ER-associated glycoprotein folding process.

BindingDB (2026) · UC San Diego · doi:10.7270/q2sn0fxs

1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature

Wang, H., Shen, Y., Zhao, L., & Ye, Y. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327666200114112728 · Cited by 64 · see citing works

Extraction and characteristics of 1-deoxynojirimycin from mulberry leaves.

TingTing, X., Qing-yuan, S., HuaXuan, W., & Zhang, H. (2018) · Dalian Qinggongye Xueyuan xuebao

Advances in DNJ Extraction,Purification and Determination in Mulberry Plants

Sun, G. (2011) · Research and Exploration in Laboratory

Insights into the Activities and Usefulness of Deoxynojirimycin and Morus alba: A Comprehensive Review

Tricase, A. F., Cavalluzzi, M. M., Catalano, A. A., Bellis, M. D., Palma, A. D., Basile, G., Sinicropi, M. S., & Lentini, G. (2025) · Molecules · doi:10.3390/molecules30153213 · Cited by 15 · see citing works

1-脱氧野尻霉素（DNJ）的研究进展

冉艳萍, 廖森泰, & 刘吉平 (2012) · 广东蚕业