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Cited by 30Bone Tissue Engineering MaterialsPolymer Surface Interaction StudiesSurface Treatment and Coatings

Improving Hydrophilicity and Inducing Bone-Like Apatite Formation on PPBES by Polydopamine Coating for Biomedical Application

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Liu, Chengde, Li, Yizheng, Wang, Jinyan, Liu, Cheng, Liu, Wentao, Jian, Xigao·2018·Molecules
DOI 10.3390/molecules23071643PMC PMC6100182
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Abstract

Copoly(phthalazinone biphenyl ether sulfone) (PPBES) as a commercially available polyarylether is a promising orthopaedic implant material because its mechanical properties are similar to bone. However, the bioinert surface of polyarylether causes some clinical problems after implantation, which limits its application as an implant material. In this study, the surface of PPBES was modified by a biomineralization method of polydopamine-assisted hydroxyapatite formation (pHAF) to enhance its cytocompatibility. Polydopamine (PDA) coating, inspired by the adhesion mechanism of mussels, can readily endow PPBES with high hydrophilicity and the ability to integrate via the bone-like apatite coating. PPBES and PDA-coated PPBES were evaluated by scanning electronic microscopy (SEM), X-ray photoelectron spectroscopy (XPS), and contact angle measurement. The water contact angles were reduced significantly after coating with PDA. PDA was successfully synthesized on PPBES and more PDA was obtained by increasing the temperature. Bone-like apatite on PPBES (apatite-coated PPBES) was confirmed by SEM and transmission electron microscopy (TEM). The cytotoxicity of pristine PPBES and apatite-coated PPBES were characterized by culturing of NIH-3T3 cells. Bone-like apatite synthesized by pHAF could further enhance cytocompatibility in vitro. This study provides a promising alternative for biofunctionalized PPBES with improved cytocompatibility for bone implant application.

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Cited by

Sorted by citations

Authors
Liu, C., Li, Y., Wang, J., Liu, C., Liu, W., & Jian, X.
Affiliations
  • Dalian University of Technology (CN)
  • State Key Laboratory of Fine Chemicals, Dalian University of Technology, Dalian 116024, China
  • Department of Polymer Science & Engineering, Dalian University of Technology, Dalian 116024, China
Corresponding author
Jian, Xigao
ORCID
Venue
Molecules
Publisher
MDPI AG
Published
2018-07-05
Volume
23
Issue
7
Pages
1643
ISSN
1420-3049 (ISSN-L)
DOI
10.3390/molecules23071643
PMC
PMC6100182
OpenAlex
W2810001027
Cited by
30
References
2
Citations by year
2026: 1 · 2025: 2 · 2024: 8 · 2023: 5 · 2022: 4 · 2021: 5 · 2020: 3 · 2019: 2
FWCI
1.00
Type
journal article
Language
en
Open access
Licence
Locations
  • Molecules (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
  • National Natural Science Foundation of China (No. 51503025)
  • China Postdoctoral Science Foundation (No. 2016M591426)
  • National Key R&D Program of China (No. 2017YFB0307600)
  • Liaoning Natural Science Foundation of China (No. 201501174 and 20170540175)
Topics
  • Physical Sciences › Engineering › Biomedical Engineering › Bone Tissue Engineering Materials
  • Physical Sciences › Materials Science › Surfaces, Coatings and Films › Polymer Surface Interaction Studies
  • Physical Sciences › Engineering › Mechanical Engineering › Surface Treatment and Coatings
Keywords
polydopamine coating, hydroxyapatite formation, biomineralization, hydrophilicity, orthopedic implants, bone-like apatite, cytocompatibility, NIH3T3 cells, surface modification, biofunctionalization
MeSH terms
Animals, Cell Survival, Hydroxyapatites, Indoles, Microscopy, Electron, Scanning, Osteogenesis, Polymers, Surface Properties, Durapatite, Coated Materials, Biocompatible, NIH 3T3 Cells, Mice, Photoelectron Spectroscopy, Hydrophobic and Hydrophilic Interactions

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