Application of Dendrimers for the Treatment of Infectious Diseases
Open accessAbstract
Dendrimers are drug delivery systems that are characterized by a three-dimensional, star-shaped, branched macromolecular network. They possess ideal properties such as low polydispersity index, biocompatibility and good water solubility. They are made up of the interior and the exterior layers. The exterior layer consists of functional groups that are useful for conjugation of drugs and targeting moieties. The interior layer exhibits improved drug encapsulation efficiency, reduced drug toxicity, and controlled release mechanisms. These unique properties make them useful for drug delivery. Dendrimers have attracted considerable attention as drug delivery system for the treatment of infectious diseases. The treatment of infectious diseases is hampered severely by drug resistance. Several properties of dendrimers such as their ability to overcome drug resistance, toxicity and control the release mechanism of the encapsulated drugs make them ideal systems for the treatment of infectious disease. The aim of this review is to discuss the potentials of dendrimers for the treatment of viral and parasitic infections.
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Dendrimers consist of an inner layer and an outer layer; functional groups for drug conjugation and targeting make up the outer layer; drug encapsulation efficiency, drug toxicity, and controlled release mechanisms are improved in the inner layer.
“They consist of an inner layer and an outer layer. Functional groups that are used for drug conjugation and targeting make up the outer layer. The drug encapsulation efficiency, drug toxicity, and controlled release mechanisms are all improved in the inner layer.26”
From Smart nanoparticles for cancer therapy (2023) · cites this paper as [26]
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- Authors
- Mhlwatika, Z., & Aderibigbe, B. A.
- Affiliations
- University of Fort Hare (ZA)
- Corresponding author
- Aderibigbe, Blessing Atim
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2018-08-31
- Volume
- 23
- Issue
- 9
- Pages
- 2205
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6225509
- OpenAlex
- W2889191478
- Cited by
- 97
- References
- 188
- Citations by year
- 2026: 4 · 2025: 10 · 2024: 11 · 2023: 12 · 2022: 16 · 2021: 12 · 2020: 25 · 2019: 6 · 2016: 1
- FWCI
- 0.84
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- Europe PMC (PubMed Central) (publishedVersion, other-oa)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion)
- Funders
- National Research Foundation
- South African Medical Research Council
- University of Fort Hare
- Medical Research Council
- Topics
- Physical Sciences › Materials Science › Polymers and Plastics › Dendrimers and Hyperbranched Polymers
- Physical Sciences › Materials Science › Biomaterials › Nanoparticle-Based Drug Delivery
- Life Sciences › Pharmacology, Toxicology and Pharmaceutics › Pharmaceutical Science › Advanced Drug Delivery Systems
- Keywords
- dendrimers, drug delivery systems, infectious diseases, drug resistance, viral infection, parasitic infection, controlled drug release, drug encapsulation, biocompatibility, targeting moieties
- MeSH terms
- Communicable Diseases, Pharmaceutical Preparations, Humans, Dendrimers
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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