The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
New Advances in General Biomedical Applications of PAMAM Dendrimers
Open accessAbstract
Dendrimers are nanoscopic compounds, which are monodispersed, and they are generally considered as homogeneous. PAMAM (polyamidoamine) was introduced in 1985, by Donald A. Tomalia, as a new class of polymers, named ‘starburst polymers’. This important contribution of Professor Tomalia opened a new research field involving nanotechnological approaches. From then on, many groups have been using PAMAM for diverse applications in many areas, including biomedical applications. The possibility of either linking drugs and bioactive compounds, or entrapping them into the dendrimer frame can improve many relevant biological properties, such as bioavailability, solubility, and selectivity. Directing groups to reach selective delivery in a specific organ is one of the advanced applications of PAMAM. In this review, structural and safety aspects of PAMAM and its derivatives are discussed, and some relevant applications are briefly presented. Emphasis has been given to gene delivery and targeting drugs, as advanced delivery systems using PAMAM and an incentive for its use on neglected diseases are briefly mentioned.
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Preparation and application of pH-responsive drug delivery systems
Ding, H., Tan, P., Fu, S., Tian, X., Zhang, H., Ma, X., Gu, Z., & Luo, K. (2022) · Journal of Controlled Release · doi:10.1016/j.jconrel.2022.05.056 · Cited by 645
Dendrimer-based drug delivery systems: history, challenges, and latest developments
Wang, J., Li, B., Qiu, L., Qiao, X., & Yang, H. (2022) · Journal of Biological Engineering · doi:10.1186/s13036-022-00298-5 · Cited by 406
Polymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Santa Chalarca, C. F., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 365
Dendrimers as Pharmaceutical Excipients: Synthesis, Properties, Toxicity and Biomedical Applications
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Metadata
- Authors
- Araújo, R. V. D., Santos, S. D. S., Igne Ferreira, E., & Giarolla, J.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2018-11-02
- Volume
- 23
- Issue
- 11
- Pages
- 2849
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W2899134141
- Cited by
- 265
- References
- 131
- FWCI
- 13.01
- Type
- journal article
- Language
- en
- Open access
- gold
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