The DOI matches its Crossref record; 238 of the 240 references it cites were found in a registry or an index.
Lactoferrin in Aseptic and Septic Inflammation
Open accessAbstract
Lactoferrin (Lf), a cationic glycoprotein able to chelate two ferric irons per molecule, is synthesized by exocrine glands and neutrophils. Since the first anti-microbial function attributed to Lf, several activities have been discovered, including the relevant anti-inflammatory one, especially associated to the down-regulation of pro-inflammatory cytokines, as IL-6. As high levels of IL-6 are involved in iron homeostasis disorders, Lf is emerging as a potent regulator of iron and inflammatory homeostasis. Here, the role of Lf against aseptic and septic inflammation has been reviewed. In particular, in the context of aseptic inflammation, as anemia of inflammation, preterm delivery, Alzheimer’s disease and type 2 diabetes, Lf administration reduces local and/or systemic inflammation. Moreover, Lf oral administration, by decreasing serum IL-6, reverts iron homeostasis disorders. Regarding septic inflammation occurring in Chlamydia trachomatis infection, cystic fibrosis and inflammatory bowel disease, Lf, besides the anti-inflammatory activity, exerts a significant activity against bacterial adhesion, invasion and colonization. Lastly, a critical analysis of literature in vitro data reporting contradictory results on the Lf role in inflammatory processes, ranging from pro- to anti-inflammatory activity, highlighted that they depend on cell models, cell metabolic status, stimulatory or infecting agents as well as on Lf iron saturation degree, integrity and purity.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Claims other papers make about this one
Each is checked against this paper’s own text: does it say what the citing paper says it does?
In the citing paper
“In addition to its role in scavenging iron, lactoferrin, through binding to its cognate receptor, promotes the maturation, migration and cell proliferation of many immune cells including macrophages and monocytes which impact on the efficacy of host responses in the course of infections (Actor et al., 2009; Legrand, 2012; Lepanto et al., 2019).”
From The Role of Iron Regulation in Immunometabolism and Immune-Related Disease (2019) · cites this paper as Lepanto et al., 2019
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Mizgerd, J. P., Kubo, H., Kutkoski, G. J., Bhagwan, S. D., Scharffetter-Kochanek, K., Beaudet, A. L., & Doerschuk, C. M. (1997) · The Journal of Experimental Medicine · doi:10.1084/jem.186.8.1357 · Cited by 7,332
Tolerance, Danger, and the Extended Family
Matzinger, P. (1994) · Annual Review of Immunology · doi:10.1146/annurev.iy.12.040194.005015 · Cited by 4,848
Targeting Hypoxia-Inducible Factors for the Treatment of Anemia in Chronic Kidney Disease Patients
Locatelli, F., Fishbane, S. N., Block, G. A., & Macdougall, I. C. (2017) · American Journal of Nephrology · doi:10.1159/000455166 · Cited by 4,836
Ecological and Evolutionary Forces Shaping Microbial Diversity in the Human Intestine
Ley, R. E., Peterson, D. A., & Gordon, J. I. (2006) · Cell · doi:10.1016/j.cell.2006.02.017 · Cited by 3,358
The gut flora as a forgotten organ
O'Hara, A. M., & Shanahan, F. (2006) · The EMBO Reports · doi:10.1038/sj.embor.7400731 · Cited by 2,791
Hotamisligil, G. S., Peraldi, P., Budavari, A., Ellis, R., White, M. F., & Spiegelman, B. M. (1996) · Science · doi:10.1126/science.271.5249.665 · Cited by 2,630
Hepcidin, a urinary antimicrobial peptide synthesized in the liver
Park, C. H., Valore, E. V., Waring, A. J., & Ganz, T. (2001) · Journal of Biological Chemistry · doi:10.1074/jbc.m008922200 · Cited by 2,168
Andrews, N. C. (1999) · New England Journal of Medicine · doi:10.1056/nejm199912233412607 · Cited by 2,130
Ferric Carboxymaltose in Patients with Heart Failure and Iron Deficiency
Anker, S. D., Comin Colet, J., Filippatos, G., Willenheimer, R., Dickstein, K., Drexler, H., Lüscher, T. F., Bart, B., Banasiak, W., Niegowska, J., et al. (2009) · New England Journal of Medicine · doi:10.1056/nejmoa0908355 · Cited by 2,083 · cited 1×
“AI is common in patients suffering from chronic diseases with prolonged inflammation due to aseptic diseases as cancer and obesity [75,76].”
BackgroundAn ecological and evolutionary perspective on human–microbe mutualism and disease
Dethlefsen, L., McFall-Ngai, M., & Relman, D. A. (2007) · Nature · doi:10.1038/nature06245 · Cited by 1,660
Flagged first, then by citations
2 of the 240 references couldn’t be matched to a known paper.
Research works printed but not linked: 1
- Hainer, 2011, Vaginitis: Diagnosis and Treatment, Am. Fam. Physician., 83, 807
Cited by
Sorted by citations
Kell, D. B., Heyden, E. L., & Pretorius, E. (2020) · Frontiers in Immunology · doi:10.3389/fimmu.2020.01221 · Cited by 460
The Role of Iron Regulation in Immunometabolism and Immune-Related Disease
Cronin, S. J. F., Woolf, C. J., Weiss, G., & Penninger, J. M. (2019) · Frontiers in Molecular Biosciences · doi:10.3389/fmolb.2019.00116 · Cited by 299
Habib, H. M., Ibrahim, S., Zaim, A., & Ibrahim, W. H. (2021) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2021.111228 · Cited by 259
Lactoferrin’s Anti-Cancer Properties: Safety, Selectivity, and Wide Range of Action
Cutone, A., Rosa, L., Ianiro, G., Lepanto, M. S., di Patti, M. C. B., Valenti, P., & Musci, G. (2020) · Biomolecules · doi:10.3390/biom10030456 · Cited by 212
Elzoghby, A. O., Abdelmoneem, M. A., Hassanin, I. A., Elwakil, M. M. A., Elnaggar, M. A., Mokhtar, S., Fang, J., & Elkhodairy, K. A. (2020) · Biomaterials · doi:10.1016/j.biomaterials.2020.120355 · Cited by 203
Gruden, Š., & Ulrih, N. P. (2021) · International Journal of Molecular Sciences · doi:10.3390/ijms222011264 · Cited by 187
Agrawal, M., Saraf, S., Saraf, S., Antimisiaris, S. G., Hamano, N., Li, S., Chougule, M. B., Shoyele, S., Gupta, U. D., Ajazuddin, M., et al. (2018) · Expert Opinion on Drug Delivery · doi:10.1080/17425247.2018.1471058 · Cited by 101
Lactoferrin Against SARS-CoV-2: In Vitro and In Silico Evidences
Campione, E., Lanna, C., Cosio, T., Rosa, L., Conte, M. P., Iacovelli, F., Romeo, A., Falconi, M., Vecchio, C. D., Franchin, E., et al. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.666600 · Cited by 100
A Review on Lactoferrin and Central Nervous System Diseases
Li, Y.-Q., & Guo, C. (2021) · Cells · doi:10.3390/cells10071810 · Cited by 92
Recent Insights Into the Prognostic and Therapeutic Applications of Lysozymes
Jiang, L., Li, Y., Wang, L., Guo, J., Liu, W., Meng, G., Zhang, L., Li, M., Cong, L., & Sun, M. (2021) · Frontiers in Pharmacology · doi:10.3389/fphar.2021.767642 · Cited by 87
Lactoferrin as Antiviral Treatment in COVID-19 Management: Preliminary Evidence
Campione, E., Lanna, C., Cosio, T., Rosa, L., Conte, M. P., Iacovelli, F., Romeo, A., Falconi, M., Vecchio, C. D., Franchin, E., et al. (2021) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph182010985 · Cited by 79
Hong, L., Chen, G., Cai, Z., Liu, H., Zhang, C., Wang, F., Xiao, Z., Zhong, J., Wang, L., Wang, Z., et al. (2022) · Advanced Science · doi:10.1002/advs.202200281 · Cited by 75
Cutone, A., Lepanto, M. S., Rosa, L., Scotti, M. J., Rossi, A., Ranucci, S., Fino, I. D., Bragonzi, A., Valenti, P., Musci, G., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20092128 · Cited by 69
Mann, J. K., & Ndung’u, T. (2020) · Future Virology · doi:10.2217/fvl-2020-0170 · Cited by 65
The Functional Role of Lactoferrin in Intestine Mucosal Immune System and Inflammatory Bowel Disease
Liu, N., Feng, G., Zhang, X., Hu, Q., Sun, S., Sun, J., Sun, Y., Wang, R., Zhang, Y., Wang, P., et al. (2021) · Frontiers in Nutrition · doi:10.3389/fnut.2021.759507 · Cited by 68
Ohradanova‐Repic, A., Praženicová, R., Gebetsberger, L., Moskalets, T., Škrabana, R., Cehlár, O., Tajti, G., Stockinger, H. S. J., & Leksa, V. (2023) · Pharmaceutics · doi:10.3390/pharmaceutics15041056 · Cited by 67
Artym, J., Zimecki, M., & Kruzel, M. L. (2021) · Biomedicines · doi:10.3390/biomedicines9080898 · Cited by 58
Viral Hepatitis and Iron Dysregulation: Molecular Pathways and the Role of Lactoferrin
Mancinelli, R., Rosa, L., Cutone, A., Lepanto, M. S., Franchitto, A., Onori, P., Gaudio, E., & Valenti, P. (2020) · Molecules · doi:10.3390/molecules25081997 · Cited by 56
Rosa, L., Tripepi, G. L., Naldi, E., Aimati, M., Santangeli, S., Venditto, F., Caldarelli, M., & Valenti, P. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10184276 · Cited by 51
Artym, J., & Zimecki, M. (2021) · Biomedicines · doi:10.3390/biomedicines9121940 · Cited by 51
Protective Effects of Antioxidants on Cyclophosphamide-Induced Ovarian Toxicity
Barberino, R. D. S., Silva, R. L. D. S., Palheta, R. C., Smitz, J. E. J., & Matos, M. H. T. (2022) · Biopreservation and Biobanking · doi:10.1089/bio.2021.0159 · Cited by 46
Lactoferrin for COVID-19 prevention, treatment, and recovery
Bolat, E., Eker, F., Kaplan, M., Duman, H., Arslan, A., Sarıtaş, S., Şahutoğlu, A. S., & Karav, S. (2022) · Frontiers in Nutrition · doi:10.3389/fnut.2022.992733 · Cited by 50
Cutone, A., Colella, B., Pagliaro, A., Rosa, L., Lepanto, M. S., di Patti, M. C. B., Valenti, P., Bartolomeo, S. D., & Musci, G. (2019) · Cellular Signalling · doi:10.1016/j.cellsig.2019.109461 · Cited by 45
COVID-19 Infection in Children and Infants: Current Status on Therapies and Vaccines
Malcangi, G., Inchingolo, A. D., Inchingolo, A. M., Piras, F., Settanni, V., Garofoli, G., Palmieri, G., Ceci, S., Patano, A., Mancini, A., et al. (2022) · Children · doi:10.3390/children9020249 · Cited by 49
The 15-Months Clinical Experience of SARS-CoV-2: A Literature Review of Therapies and Adjuvants
Inchingolo, A. D., Dipalma, G., Inchingolo, A. M., Malcangi, G., Santacroce, L., D’Oria, M. T., Isacco, C. G., Bordea, I. R., Candrea, S., Scarano, A., et al. (2021) · Antioxidants · doi:10.3390/antiox10060881 · Cited by 54
Lactoferrin: from the structure to the functional orchestration of iron homeostasis
Ianiro, G., Rosa, L., di Patti, M. C. B., Valenti, P., Musci, G., & Cutone, A. (2022) · BioMetals · doi:10.1007/s10534-022-00453-x · Cited by 44
Cutone, A., Ianiro, G., Lepanto, M. S., Rosa, L., Valenti, P., di Patti, M. C. B., & Musci, G. (2020) · Cancers · doi:10.3390/cancers12123806 · Cited by 40
Sinopoli, A., Isonne, C., Santoro, M., & Baccolini, V. (2021) · Reviews in Medical Virology · doi:10.1002/rmv.2261 · Cited by 35
Vickram, A. S., Anbarasu, K., Palanivelu, J., Gulothungan, G., Nanmaran, R., Sundaram, T., Sridharan, T. B., & Karunakaran, R. (2021) · Frontiers in Medicine · doi:10.3389/fmed.2021.723019 · Cited by 35
The Multifaceted Functions of Lactoferrin in Antimicrobial Defense and Inflammation
Kim, J. W., Lee, J. S., Choi, Y. J., & Kim, C. (2025) · Biomolecules · doi:10.3390/biom15081174 · Cited by 42
The Role of Nutrients in Prevention, Treatment and Post-Coronavirus Disease-2019 (COVID-19)
Motti, M. L., Tafuri, D., Donini, L. M., Masucci, M. T., Falco, V. D., & Mazzeo, F. (2022) · Nutrients · doi:10.3390/nu14051000 · Cited by 35
Lactoferrin: Cytokine Modulation and Application in Clinical Practice
Presti, S., Manti, S., Parisi, G. F., Papale, M. R., Barbagallo, I. A., Volti, G. L., & Leonardi, S. (2021) · Journal of Clinical Medicine · doi:10.3390/jcm10235482 · Cited by 34
Biomedical and Nutritional Applications of Lactoferrin
Coccolini, C., Berselli, E., Blanco-Llamero, C., Fathi, F., Oliveira, M. B. P. P., Krambeck, K., & Souto, E. B. (2023) · International Journal of Peptide Research and Therapeutics · doi:10.1007/s10989-023-10541-2 · Cited by 31
The effect of lactoferrin in aging: role and potential
Li, B., Zhang, B., Liu, X., Zheng, Y., Han, K., Liu, H., Wu, C., Li, J., Fan, S., Peng, W., et al. (2021) · Food & Function · doi:10.1039/d1fo02750f · Cited by 32
Lactoferrin and oral pathologies: a therapeutic treatment
Rosa, L., Lepanto, M. S., Cutone, A., Ianiro, G., Pernarella, S., Sangermano, R., Musci, G., Ottolenghi, L., & Valenti, P. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0052 · Cited by 33
Alyasin, S. S., Nabavizadeh, S. H., Esmaeilzadeh, H., Heydari, S. T., Mosavat, S. H., Parvizi, M. M., Hashemi, S. M., & Hashempur, M. H. (2020) · Dermatologic Therapy · doi:10.1111/dth.14260 · Cited by 30
Rosa, L., Lepanto, M. S., Cutone, A., Siciliano, R. A., Paesano, R., Costi, R., Musci, G., & Valenti, P. (2020) · BioMetals · doi:10.1007/s10534-020-00236-2 · Cited by 30
Olsen, I., & Singhrao, S. K. (2020) · Medical Hypotheses · doi:10.1016/j.mehy.2020.110393 · Cited by 29
Wang, L., & Cao, Q. (2021) · The Kaohsiung Journal of Medical Sciences · doi:10.1002/kjm2.12442 · Cited by 28
Potential of Lactoferrin in the Treatment of Lung Diseases
Kaczyńska, K., Jampolska, M., Wojciechowski, P., Sulejczak, D., Andrzejewski, K., & Zając, D. (2023) · Pharmaceuticals · doi:10.3390/ph16020192 · Cited by 28
Lactoferrin: Current situation and future prospects
Hu, C., Shen, W., Xia, Y., Yang, H., & Chen, X. (2024) · Food Bioscience · doi:10.1016/j.fbio.2024.105183 · Cited by 23
Gori, A., Brindisi, G., Daglia, M., del Giudice, M. M., Dinardo, G., Minno, A. D., Drago, L., Indolfi, C., Naso, M., Trincianti, C., et al. (2024) · Nutrients · doi:10.3390/nu16121906 · Cited by 22
Khan, A. I., Liu, J., & Dutta, P. (2019) · Biochimica et Biophysica Acta (BBA) - General Subjects · doi:10.1016/j.bbagen.2019.129459 · Cited by 22
Role of Atypical Chemokines and Chemokine Receptors Pathways in the Pathogenesis of COPD
Nucera, F., Bello, F. L., Shen, S., Ruggeri, P., Coppolino, I., Stefano, A. D., Stellato, C., Casolaro, V., Hansbro, P. M., Adcock, I. M., et al. (2020) · Current Medicinal Chemistry · doi:10.2174/0929867327999200819145327 · Cited by 21
Lactoferrin-Conjugated Nanoparticles as New Antivirals
Krzyżowska, M., Janicka, M., Tomaszewska, E., Ranoszek‐Soliwoda, K., Celichowski, G., Grobelny, J., & Szymański, P. (2022) · Pharmaceutics · doi:10.3390/pharmaceutics14091862 · Cited by 20
Artym, J., & Zimecki, M. (2023) · Biomedicines · doi:10.3390/biomedicines11010114 · Cited by 20
Anand, N. (2024) · Frontiers in Parasitology · doi:10.3389/fpara.2023.1330398 · Cited by 20
Malcangi, G., Inchingolo, A. D., Inchingolo, A. M., Santacroce, L., Marinelli, G., Mancini, A., Vimercati, L., Maggiore, M. E., D’Oria, M. T., Hazballa, D., et al. (2021) · Microorganisms · doi:10.3390/microorganisms9091964 · Cited by 31
Ianiro, G., D’Ezio, V., Carpinelli, L., Casella, C., di Patti, M. C. B., Rosa, L., Valenti, P., Colasanti, M., Musci, G., Cutone, A., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24097947 · Cited by 19
Brink, L., Chichlowski, M., Pastor, N., Athmaram, T. N., & Shah, N. (2021) · Nutrients · doi:10.3390/nu13030870 · Cited by 18
Multi-omics analysis of five species of milk and specific composition links within each species
Li, Q., Wang, X., Zhang, Q., Wu, Y., Chen, R., Sun, Y., Pan, Y., Li, S., & Wang, Z. (2024) · Food Chemistry · doi:10.1016/j.foodchem.2024.140028 · Cited by 18
Xu, D., Fang, M., Wang, Q., Qiao, Y., Li, Y., & Wang, L. (2021) · ACS Applied Bio Materials · doi:10.1021/acsabm.1c00841 · Cited by 20
Lactoferrin: A Promising Therapeutic Molecule against Human Papillomavirus
Kaplan, M., Baktıroğlu, M., Kalkan, A. E., Canbolat, A. A., Lombardo, M., Raposo, A., Alves, J. L. D. B., Witkowska, A. M., & Karav, S. (2024) · Nutrients · doi:10.3390/nu16183073 · Cited by 17
Cryo-nanoimaging of Single Human Macrophage Cells: 3D Structural and Chemical Quantification
Gramaccioni, C., Yang, Y., Pacureanu, A., Viganò, N., Procopio, A., Valenti, P., Rosa, L., Berlutti, F., Bohic, S., & Cloetens, P. (2020) · Analytical Chemistry · doi:10.1021/acs.analchem.9b04096 · Cited by 17
Nemati, M., Akseh, S., Amiri, M., Nejabati, H. R., Jodati, A., Maroufi, N. F., Faridvand, Y., & Nouri, M. (2021) · Immunopharmacology and Immunotoxicology · doi:10.1080/08923973.2021.1872616 · Cited by 17
Can Lactoferrin, a Natural Mammalian Milk Protein, Assist in the Battle against COVID-19?
Einerhand, A. W. C., Bouwman, C. A., Weiss, G. A., Wang, C., Ba, G., Fan, Q., He, B., & Smit, G. (2022) · Nutrients · doi:10.3390/nu14245274 · Cited by 20
Av, S., Dubrovskaya, N. M., Kostevich, V. A., Vasilev, D. S., Voynova, I. V., Zakharova, E. T., Runova, O. L., Semak, I. V., Будевич, А. И., Nalivaeva, N. N., et al. (2022) · Nutrients · doi:10.3390/nu14071399 · Cited by 16
Brantl, V., Boysen, J. M., Yap, A., Golubtsov, E., Ruf, D., Heinekamp, T., Straßburger, M., Dichtl, K., Haas, H., Hillmann, F., et al. (2021) · mBio · doi:10.1128/mbio.00976-21 · Cited by 15
Campione, E., Lanna, C., Cosio, T., Rosa, L., Conte, M. P., Iacovelli, F., Romeo, A., Falconi, M., Vecchio, C. D., Franchin, E., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.08.11.244996 · Cited by 14
Lepanto, M. S., Rosa, L., Cutone, A., Scotti, M. J., Conte, A. L., Marazzato, M., Zagaglia, C., Longhi, C., Berlutti, F., Musci, G., et al. (2019) · International Journal of Molecular Sciences · doi:10.3390/ijms20225666 · Cited by 15
Artym, J., & Zimecki, M. (2023) · Biomedicines · doi:10.3390/biomedicines11041015 · Cited by 15
Av, S., Isakova–Sivak, I., Mezhenskaya, D. А., Kostevich, V. A., Gorbunov, N., Elizarova, A. Y., Matyushenko, V., Berson, Y. M., Грудинина, Н. А., Kolmakov, N. N., et al. (2022) · BioMetals · doi:10.1007/s10534-022-00458-6 · Cited by 15
Chen, X., Song, W., Zhang, H., Xu, Y., Yi, B., & Zhou, Q. (2025) · Chemical Engineering Journal · doi:10.1016/j.cej.2025.159756 · Cited by 13
Tear nanoDSF Denaturation Profile Is Predictive of Glaucoma
Baksheeva, V. E., Tiulina, V. V., Иомдина, Е. Н., Petrov, S. Y., Filippova, O. M., Kushnarevich, N. Y., Suleiman, E. A., Eyraud, R., Devred, F., Serebryakova, M. V., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms24087132 · Cited by 13
Human Mesenchymal Stem Cell Response to Lactoferrin-based Composite Coatings
Icriverzi, M., Bonciu, A. F., Rusen, L., Sima, L. E., Brajnicov, S., Cîmpean, A., Evans, R. W., Dinca, V. C., & Roșeanu, A. (2019) · Materials · doi:10.3390/ma12203414 · Cited by 13
Ng, Z. J., Daud, M. F. A. B. M., Lian, K. O. B., Migeemanathan, S., Shin, G. K., Shunmugham, T. R., Hee, J. C. T., Wei, T. H., Ling, K. Y., Sa’aid, N., et al. (2025) · Trends in Food Science & Technology · doi:10.1016/j.tifs.2025.105024 · Cited by 12
Stealthy microbes: How Neisseria gonorrhoeae hijacks bulwarked iron during infection
Stoudenmire, J. L., Greenawalt, A. N., & Cornelissen, C. N. (2022) · Frontiers in Cellular and Infection Microbiology · doi:10.3389/fcimb.2022.1017348 · Cited by 12
Nbr1-regulated autophagy in Lactoferrin-induced osteoblastic differentiation
Zhang, Y., Zhang, Z.-N., Li, N., Zhao, L.-J., Xue, Y., Wu, H., & Hou, J. (2020) · Bioscience Biotechnology and Biochemistry · doi:10.1080/09168451.2020.1737505 · Cited by 12
The role of nutrition on the treatment of Covid 19
Younes, S. (2024) · Human Nutrition & Metabolism · doi:10.1016/j.hnm.2024.200255 · Cited by 10
Antequera, D., Buetas, E., García‐Esteban, S., Romualdi, D., Carrero, L., Municio, C., Mira, Á., & Carro, E. (2025) · Frontiers in Immunology · doi:10.3389/fimmu.2025.1681095 · Cited by 13
Lactoferrin Can Attenuate SARS-CoV-2: An Analysis of Evidential Relations
Shafqat, F., Rehman, S. U., & Niaz, K. (2022) · Biomedical Research and Therapy · doi:10.15419/bmrat.v9i2.727 · Cited by 10
Nguyen, T. K. T., Niaz, Z., d’Aigle, J., Hwang, S., Kruzel, M. L., & Actor, J. K. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0057 · Cited by 10
Modulation of TDM-induced granuloma pathology by human lactoferrin: a persistent effect in mice
Actor, J. K., Nguyen, T. K. T., Wasik-Smietana, A., & Kruzel, M. L. (2022) · BioMetals · doi:10.1007/s10534-022-00434-0 · Cited by 10
Wright, S. W., Lovelace-Macon, L., Ducken, D. R., Tandhavanant, S., Teparrukkul, P., Hantrakun, V., Limmathurotsakul, D., Chantratita, N., & West, T. E. (2020) · PLoS neglected tropical diseases · doi:10.1371/journal.pntd.0008495 · Cited by 9
Darmawan, K. K., Karagiannis, T. C., Hughes, J. G., Small, D. M., & Hung, A. (2022) · Critical Reviews in Food Science and Nutrition · doi:10.1080/10408398.2022.2067824 · Cited by 9
Design of Peptide Ligand for Lactoferrin and Study of Its Binding Specificity
Zimina, T. M., Sitkov, N. O., Karasev, V., Skorik, Y. А., Kolobov, A. A., Kolobov, A. A., Bunenkov, N. S., & Luchinin, V. V. (2023) · Chemosensors · doi:10.3390/chemosensors11030162 · Cited by 8
Omiya, K., Nakadate, Y., Sato, H., Oguchi, T., Matsuoka, T., Kawakami, A., Schricker, T., & Matsukawa, T. (2023) · Nutrition · doi:10.1016/j.nut.2023.112088 · Cited by 8
Specific Changes of Erythroid Regulators and Hepcidin in Patients Infected by SARS-COV-2
Delaye, J.-B., Alarcan, H., Vallet, N., Veyrat‐Durebex, C., Bernard, L., Hérault, O., Ropert, M., Marlet, J., Gyan, E., Andres, C. R., et al. (2022) · Journal of Investigative Medicine · doi:10.1136/jim-2021-002270 · Cited by 8
Lactoferrin as Immune-Enhancement Strategy for SARS-CoV-2 Infection in Alzheimer’s Disease Patients
Bartolomé, F. B., Rosa, L., Valenti, P., Lopera, F. J., Hernández‐Gallego, J., Cantero, J. L., Orive, G., & Carro, E. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.878201 · Cited by 8
Iacovelli, F., Costanza, G., Romeo, A., Cosio, T., Lanna, C., Bagnulo, A., Maio, U. D., Sbardella, A., Gaziano, R., Grelli, S., et al. (2022) · International Journal of Environmental Research and Public Health · doi:10.3390/ijerph19095254 · Cited by 8
Effect of bovine lactoferrin on recurrent urinary tract infections: in vitro and in vivo evidences
Conte, A. L., Longhi, C., Conte, M. P., Costanzo, A. M., Paesano, R., Santangeli, S., Venditto, F., Tripepi, G. L., Naldi, E., Pollio, G., et al. (2022) · BioMetals · doi:10.1007/s10534-022-00409-1 · Cited by 9
The potential of lactoferrin: a call for future research in poultry nutrition
Saeed, M., Hussain, N., Ahmed, S., Khan, R. U., Andoh, V., Husain, S., & Huayou, C. (2023) · World s Poultry Science Journal · doi:10.1080/00439339.2023.2239764 · Cited by 9
Omiya, K., Nakadate, Y., Oguchi, T., Sato, T., Matsuoka, T., Abe, M., Kawakami, A., Matsukawa, T., & Sato, H. (2022) · BMC Pharmacology and Toxicology · doi:10.1186/s40360-022-00619-w · Cited by 7
Mann, J. K., Reddy, T., van der Stok, M., Ngubane, A., Mulaudzi, T., Mchunu, N. N., Nevhungoni, P., Manickchund, N., Manickchund, P., Cairns, C., et al. (2023) · Future Science OA · doi:10.2144/fsoa-2023-0024 · Cited by 7
Zharani, M. A., Almuqri, E. A., Mubarak, M., Aljarba, N. H., Rudayni, H. A., Yaseen, K. N., Alkahtani, S. H., Nasr, F. A., Al-Doaiss, A. A., & AlEissa, M. S. (2024) · Biomedical and Biotechnology Research Journal (BBRJ) · doi:10.4103/bbrj.bbrj_262_23 · Cited by 7
Massa, E., Pelusa, F., Celso, A. L., Madariaga, M. J., Filocco, L., Morente, C., & Ghersevich, S. A. (2020) · Biochemistry and Cell Biology · doi:10.1139/bcb-2020-0098 · Cited by 7
Urinary Reference Values and First Insight into the Urinary Proteome of Captive Giraffes
Fasoli, S., Andreani, G., Dondi, F., Ferlizza, E., Bellei, E., & Isani, G. (2020) · Animals · doi:10.3390/ani10091696 · Cited by 7
Biomaterial-Based Delivery Systems for Chemotherapeutics
Gugulothu, D. B., Dhawan, D., Sachdeva, A., Deepali, & Chauhan, M. K. (2023) · Biological and medical physics, biomedical engineering · doi:10.1007/978-981-19-9786-0_4 · Cited by 7
Li, H., Wang, X., Yang, Q., Cheng, L., & Zeng, H. (2023) · Open Life Sciences · doi:10.1515/biol-2022-0549 · Cited by 8
Li, Y., Li, J., Dong, Y., Wang, C., & Cai, Z. (2024) · Molecular Biology Reports · doi:10.1007/s11033-024-09436-2 · Cited by 7
Zhang, X., Wang, X., Li, W., Dang, C., & Diao, D. (2022) · PubMed Central · Cited by 6
Asbjornsdottir, B., Sigurðsson, S., Miranda-Ribera, A., Fiorentino, M. R., Konno, T., Lan, J., Gudmundsson, L. S., Gottfreðsson, M., Lauth, B., Birgisdóttir, B. E., et al. (2023) · International Journal of Molecular Sciences · doi:10.3390/ijms241914730 · Cited by 6
Sienkiewicz, M., Zielińska, M., Jacenik, D., Machelak, W., Owczarek, K., & Fichna, J. (2023) · Nutrition Research · doi:10.1016/j.nutres.2023.10.001 · Cited by 6
Yadav, R. K., Sangha, S. S., Yadav, S., Sharma, P., Shah, H., & Bhowmik, D. M. (2025) · Journal of the Association of Physicians of India · doi:10.59556/japi.73.0757 · Cited by 6
Pathogenic and Protective Roles of Neutrophils in Chlamydia trachomatis Infection
Wilton, Z. E. R., Jamus, A. N., Core, S. B., & Frietze, K. M. (2025) · Pathogens · doi:10.3390/pathogens14020112 · Cited by 6
An Overview on Immunity Booster Foods in Coronavirus Disease (COVID-19)
Sahiba, N., Sethiya, A., Agarwal, D. K., & Agarwal, S. (2022) · Combinatorial Chemistry & High Throughput Screening · doi:10.2174/1386207325666220629161828 · Cited by 6
Nakamura, A., Kimura, F., Tsuji, S., Hanada, T., Takebayashi, A., Takahashi, A., Kitazawa, J., Morimune, A., Amano, T., Kushima, R., et al. (2022) · Journal of Reproductive Immunology · doi:10.1016/j.jri.2022.103761 · Cited by 5
Tosca, M. A., Varricchio, A., Schiavetti, I., Naso, M., Damiani, V., & Ciprandi, G. (2024) · Allergologia et Immunopathologia · doi:10.15586/aei.v52i3.1040 · Cited by 5
Rzeszotek, S., Trybek, G., Tarnowski, M., Serwin, K., Jaroń, A., Schneider, G., Kolasa, A., & Wiszniewska, B. (2022) · Foods · doi:10.3390/foods11050685 · Cited by 5
Editorial to Special Issue—Anti-Inflammatory Activity of Natural Products
Miguel, M. G. (2020) · Molecules · doi:10.3390/molecules25081926 · Cited by 5
Metadata
- Authors
- Lepanto, M. S., Rosa, L., Paesano, R., Valenti, P., & Cutone, A.
- Affiliations
- Sapienza University of Rome (IT)
- Microbo S.R.L., 00153 Rome, Italy
- University of Molise (IT)
- Corresponding author
- Cutone, Antimo
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2019-04-03
- Volume
- 24
- Issue
- 7
- Pages
- 1323
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC6480387
- OpenAlex
- W2935579023
- Cited by
- 147
- References
- 240
- Citations by year
- 2026: 6 · 2025: 17 · 2024: 16 · 2023: 23 · 2022: 31 · 2021: 24 · 2020: 23 · 2019: 6
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- IRIS Research product catalog (Sapienza University of Rome) (submittedVersion, cc-by)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Archivio Istituzionale della Ricerca - Università degli Studi del Molise (submittedVersion)
- Funders
- Sapienza Università di Roma
- Topics
- Health Sciences › Medicine › Hematology › Iron Metabolism and Disorders
- Health Sciences › Nursing › Nutrition and Dietetics › Infant Nutrition and Health
- Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
- Keywords
- lactoferrin, sterile inflammation, septic inflammation, interleukin-6, iron homeostasis, anti-inflammatory activity, anemia of chronic disease, preterm birth, Alzheimer's disease, type 2 diabetes, Chlamydia trachomatis infection, cystic fibrosis, inflammatory bowel disease, bacterial adhesion, iron saturation
- MeSH terms
- Anemia, Animals, Anti-Infective Agents, Anti-Inflammatory Agents, Humans, Inflammation, Iron, Lactoferrin, Biomarkers, Sepsis
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
