The DOI matches its Crossref record; 86 of the 86 references it cites were found in a registry or an index.
Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs
Open accessAbstract
Diabetes Mellitus (DM) is a multi-factorial chronic health condition that affects a large part of population and according to the World Health Organization (WHO) the number of adults living with diabetes is expected to increase. Since type 2 diabetes mellitus (T2DM) is suffered by the majority of diabetic patients (around 90–95%) and often the mono-target therapy fails in managing blood glucose levels and the other comorbidities, this review focuses on the potential drugs acting on multi-targets involved in the treatment of this type of diabetes. In particular, the review considers the main systems directly involved in T2DM or involved in diabetes comorbidities. Agonists acting on incretin, glucagon systems, as well as on peroxisome proliferation activated receptors are considered. Inhibitors which target either aldose reductase and tyrosine phosphatase 1B or sodium glucose transporters 1 and 2 are taken into account. Moreover, with a view at the multi-target approaches for T2DM some phytocomplexes are also discussed.
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Cites
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“These findings have supported the relative contributions between insulin resistance and β-cell dysfunction to the pathophysiology of T2DM [22].”
BackgroundPrevalence of impaired glucose tolerance among children and adolescents with marked obesity
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Cited by
Computer especially AI-assisted drug virtual screening and design in traditional Chinese medicine
Lin, Y., Zhang, Y., Wang, D., Yang, B., & Shen, Y.-Q. (2022) · Phytomedicine · doi:10.1016/j.phymed.2022.154481 · Cited by 107
Yale, J.-F., Bodholdt, U., Catarig, A.-M., Catrina, S., Clark, A., Ekberg, N. R., Erhan, U., Holmes, P., Knudsen, S. T., Liutkus, J., et al. (2022) · BMJ Open Diabetes Research & Care · doi:10.1136/bmjdrc-2021-002619 · Cited by 50
Metadata
- Authors
- Artasensi, A., Pedretti, A., Vistoli, G., & Fumagalli, L.
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2020-04-23
- Volume
- 25
- Issue
- 8
- Pages
- 1987
- ISSN
- 1420-3049 (ISSN-L)
- OpenAlex
- W3019636814
- Cited by
- 494
- References
- 86
- FWCI
- 37.10
- Type
- journal article
- Language
- en
- Open access
- gold
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- Artasensi, A., Pedretti, A., Vistoli, G., & Fumagalli, L. (2020). Type 2 Diabetes Mellitus: A Review of Multi-Target Drugs. Molecules. https://doi.org/10.3390/molecules25081987
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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