Natural Compound-Derived Cytochrome bc1 Complex Inhibitors as Antifungal Agents

Plant essential oils for pest and disease management

Isman, M. B. (2000) · Crop Protection · doi:10.1016/s0261-2194(00)00079-x · Cited by 2,469 · see citing works

The strobilurin fungicides

Bartlett, D., Clough, J. M., Godwin, J., Hall, A. A., Hamer, M., & Parr‐Dobrzanski, B. (2002) · Pest Management Science · doi:10.1002/ps.520 · Cited by 1,709 · see citing works

The Future Challenges of Food and Agriculture: An Integrated Analysis of Trends and Solutions

Calicioglu, Ö., Flammini, A., Bracco, S., Bellù, L., & Sims, R. (2019) · Sustainability · doi:10.3390/su11010222 · Cited by 567 · see citing works

Review of strobilurin fungicide chemicals

Balba, H. M. (2007) · Journal of Environmental Science and Health Part B · doi:10.1080/03601230701316465 · Cited by 405 · see citing works

Synthetic plant defense elicitors

BEKTAŞ, Y., & Eulgem, T. (2015) · Frontiers in Plant Science · doi:10.3389/fpls.2014.00804 · Cited by 333 · see citing works

The strobilurins - New antifungal antibiotics from the basidiomycete Strobilurus tenacellus.

Anke, T., Oberwinkler, F., Steglich, W., et al. (1977) · The Journal of Antibiotics · doi:10.7164/antibiotics.30.806 · Cited by 286 · see citing works

Crystallographic studies of quinol oxidation site inhibitors: a modified classification of inhibitors for the cytochrome bc(1) complex

Esser, L., Quinn, B., Li, Y.-F., Zhang, M., Elberry, M., Yu, L., Yu, C.-A., & Xia, D. (2004) · Journal of Molecular Biology · doi:10.1016/j.jmb.2004.05.065 · Cited by 285 · see citing works

Bioactive Heterocyclic Compound Classes

(2012) · Wiley eBooks · doi:10.1002/9783527664412 · Cited by 240 · see citing works

Protonmotive pathways and mechanisms in the cytochrome <i>bc</i> ₁ complex

Hunte, C., Palsdottir, H., & Trumpower, B. L. (2003) · FEBS Letters · doi:10.1016/s0014-5793(03)00391-0 · Cited by 216 · see citing works

Neopeltolide, a Macrolide from a Lithistid Sponge of the Family Neopeltidae

Wright, A. E., Botelho, J. C., Guzmán, E. A., et al. (2007) · Journal of Natural Products · doi:10.1021/np060597h · Cited by 198 · see citing works

Myxothiazol, an antibiotic from myxococcus fulvus. (myxobacterales) I. cultivation, isolation, physico-chemical and biological properties.

Gerth, K., Irschik, H., Reichenbach, H., et al. (1980) · The Journal of Antibiotics · doi:10.7164/antibiotics.33.1474 · Cited by 188 · see citing works

Computational Discovery of Picomolar Qo Site Inhibitors of Cytochrome bc1 Complex

Hao, G., Fu, W., Lĭ, H., Zhu, X., Yang, W., Huang, L.-S., Wu, J., Berry, E. A., & Yang, G. (2012) · Journal of the American Chemical Society · doi:10.1021/ja3001908 · Cited by 159 · see citing works

Natural products: a strategic lead generation approach in crop protection discovery

Lorsbach, B. A., Sparks, T. C., Cicchillo, R. M., et al. (2019) · Pest Management Science · doi:10.1002/ps.5350 · Cited by 112 · see citing works

Crocacin, a new electron transport inhibitor from Chondromyces cracatus (myxobacteria). Production, isolation, physico-chemical and biological properties.

Kunze, B., Jansen, R., Höfle, G., et al. (1994) · The Journal of Antibiotics · doi:10.7164/antibiotics.47.881 · Cited by 103 · see citing works

Miuraenamides A and B, Novel Antimicrobial Cyclic Depsipeptides from a New Slightly Halophilic Myxobacterium: Taxonomy, Production, and Biological Properties

Iizuka, T., Fudou, R., Jojima, Y., et al. (2006) · The Journal of Antibiotics · doi:10.1038/ja.2006.55 · Cited by 79 · see citing works

UK-2A, B, C and D, Novel Antifungal Antibiotics from Streptomyces sp. 517-02. I. Fermentation, Isolation, and Biological Properties.

Ueki, M., Abe, K., Hanafi, M., et al. (1996) · The Journal of Antibiotics · doi:10.7164/antibiotics.49.639 · Cited by 74 · see citing works

Synthesis of 1,2,3-Thiadiazole and Thiazole-Based Strobilurins as Potent Fungicide Candidates

Chen, L., Zhu, Y., Fan, Z., et al. (2017) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.6b05128 · Cited by 70 · see citing works

Miuraenamides: Antimicrobial Cyclic Depsipeptides Isolated from a Rare and Slightly Halophilic Myxobacterium

Ojika, M., Inukai, Y., Kito, Y., et al. (2007) · Chemistry - An Asian Journal · doi:10.1002/asia.200700233 · Cited by 66 · see citing works

Natural Product Neopeltolide as a Cytochrome bc 1 Complex Inhibitor: Mechanism of Action and Structural Modification

Zhu, X., Zhang, R., Wu, Q., et al. (2019) · Journal of Agricultural and Food Chemistry · doi:10.1021/acs.jafc.8b06195 · Cited by 66 · see citing works

The cytochrome bc 1 complex as an antipathogenic target

Fisher, N. E., Meunier, B., & Biagini, G. A. (2020) · FEBS Letters · doi:10.1002/1873-3468.13868 · Cited by 57 · see citing works

Synthesis and Fungicidal Activities of Novel Indene-Substituted Oxime Ether Strobilurins

Tu, S., Xu, L., Ye, L., et al. (2008) · Journal of Agricultural and Food Chemistry · doi:10.1021/jf800273t · Cited by 54 · see citing works

Chemistry of Biologically Active Isothiazoles

Clerici, F., Gelmi, M. L., Pellegrino, S., et al. (2007) · Springer eBooks · doi:10.1007/7081_2007_081 · Cited by 45 · see citing works

The stereochemistry of myxothiazol

Trowitzsch, W., Höfle, G., & Sheldrick, W. S. (1981) · Tetrahedron Letters · doi:10.1016/s0040-4039(01)91320-6 · Cited by 44 · see citing works

The discovery of SYP‐10913 and SYP‐11277: novel strobilurin acaricides

Chai, B., Liu, C., Li, H., et al. (2011) · Pest Management Science · doi:10.1002/ps.2164 · Cited by 42 · see citing works

Discovery of metyltetraprole: Identification of tetrazolinone pharmacophore to overcome QoI resistance

Matsuzaki, Y., Yoshimoto, Y., Arimori, S., et al. (2019) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2019.115211 · Cited by 42 · see citing works

The role of molecular modeling in the design of analogues of the fungicidal natural products crocacins A and D

Crowley, P., Berry, E. A., Cromartie, T. H., et al. (2008) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2008.10.030 · Cited by 40 · see citing works

Design, synthesis and structure–activity relationship of novel oxime ether strobilurin derivatives containing substituted benzofurans

Xie, Y., Huang, Y., Liu, J., et al. (2014) · Pest Management Science · doi:10.1002/ps.3819 · Cited by 38 · see citing works

Base- and Sugar-Modified Cytidine MonophosphateN-Acetylneuraminic Acid (CMP-Neu5Ac) Analogues - Synthesis and Studies with α(2-6)-Sialyltransferase from Rat Liver

Dufner, G., Schwörer, R., Müller, B. H., et al. (2000) · European Journal of Organic Chemistry · doi:10.1002/(sici)1099-0690(200004)2000:8 · Cited by 38 · see citing works

Synthesis and fungicidal activities of novel benzothiophene-substituted oxime ether strobilurins

Tu, S., Xie, Y., Gui, S., et al. (2014) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2014.03.024 · Cited by 30 · see citing works

Differential efficacy of inhibition of mitochondrial and bacterial cytochrome bc1 complexes by center N inhibitors antimycin, ilicicolin H and funiculosin

Rotsaert, F. A. J., Ding, M. G., & Trumpower, B. L. (2007) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2007.10.011 · Cited by 30 · see citing works

Biosynthesis of Myxothiazol Z, the Ester-analog of Myxothiazol A in Myxococcus fulvus

Steinmetz, H., Forche, E., Reichenbach, H., et al. (2000) · Tetrahedron · doi:10.1016/s0040-4020(00)00063-6 · Cited by 29 · see citing works

Design, Synthesis, and Biological Activity of Oxime Ether Strobilurin Derivatives Containing Indole Moiety as Novel Fungicide

Xie, Y., Huang, Z., Yan, H., et al. (2014) · Chemical Biology & Drug Design · doi:10.1111/cbdd.12460 · Cited by 29 · see citing works

Novel Methoxymethacrylate Natural Products Uncovered by Statistics-Based Mining of the Myxococcus fulvus Secondary Metabolome

Panter, F., Krug, D., & Müller, R. (2018) · ACS Chemical Biology · doi:10.1021/acschembio.8b00948 · Cited by 29 · see citing works

Cyrmenins, Novel Antifungal Peptides Containing a Nitrogen‐Linked β‐Methoxyacrylate Pharmacophore: Isolation and Structural Elucidation

Leibold, T., Sasse, F., Reichenbach, H., et al. (2004) · European Journal of Organic Chemistry · doi:10.1002/ejoc.200300367 · Cited by 28 · see citing works

Synthesis and fungicidal activity of 3,4-dichloroisothiazole based strobilurins as potent fungicide candidates

Chen, L., Guo, X., Fan, Z., et al. (2017) · RSC Advances · doi:10.1039/c6ra25520e · Cited by 28 · see citing works

KR025, a New Cytotoxic Compound from Myxococcus fulvus

Ahn, J., Woo, S.-H., Lee, C. O., et al. (1999) · Journal of Natural Products · doi:10.1021/np9804233 · Cited by 26 · see citing works

Synthesis and biological activity of analogs of the antifungal antibiotic UK‐2A. I. Impact of picolinamide ring replacement

OWEN, W. J., Meyer, K. G., Slanec, T. J., et al. (2018) · Pest Management Science · doi:10.1002/ps.5130 · Cited by 25 · see citing works

First Total Synthesis of Cyrmenin B1

Chakor, N. S., Musso, L., & Dallavalle, S. (2008) · The Journal of Organic Chemistry · doi:10.1021/jo802209m · Cited by 24 · see citing works

Structure–activity relationships of analogs of 3,4,5-trimethylfuran-2(5H)-one with germination inhibitory activities

Pošta, M., Light, M. E., Papenfus, H. B., et al. (2013) · Journal of Plant Physiology · doi:10.1016/j.jplph.2013.04.002 · Cited by 24 · see citing works

Alterations of cellular redox homeostasis in cultured fibroblast-like renal cells upon exposure to low doses of cytochrome bc1 complex inhibitor kresoxim-methyl

Flampouri, E., Mavrikou, S., Mouzaki-Paxinou, A.-C., & Kintzios, S. E. (2016) · Biochemical Pharmacology · doi:10.1016/j.bcp.2016.06.002 · Cited by 23 · see citing works

Discovery of cytochrome bc 1 complex inhibitors inspired by the natural product karrikinolide

Chen, C., Wu, Q., Shan, L.-Y., et al. (2016) · RSC Advances · doi:10.1039/c6ra19424a · Cited by 22 · see citing works

Synthesis and biological activity of analogs of the antifungal antibiotic UK‐2A. II. Impact of modifications to the macrocycle benzyl position

OWEN, W. J., Meyer, K. G., Meyer, S. T., et al. (2019) · Pest Management Science · doi:10.1002/ps.5329 · Cited by 22 · see citing works

Design, Synthesis, and Bioevaluation of Novel Strobilurin Derivatives

Zhu, X., Wang, F., Li, H., et al. (2012) · Chinese Journal of Chemistry · doi:10.1002/cjoc.201200607 · Cited by 21 · see citing works

Design, synthesis and fungicidal evaluation of novel pyraclostrobin analogues

Wang, L., Zhao, S., Kong, X., et al. (2018) · Bioorganic & Medicinal Chemistry · doi:10.1016/j.bmc.2018.01.004 · Cited by 20 · see citing works

Synthesis, fungicidal activity, structure-activity relationships (SARs) and density functional theory (DFT) studies of novel strobilurin analogues containing arylpyrazole rings

Liu, Y., Lv, K., Li, Y., et al. (2018) · Scientific Reports · doi:10.1038/s41598-018-26154-5 · Cited by 19 · see citing works

Design, Synthesis and Fungicidal Activities of Novel 1,2,3‐Triazole Functionalized Strobilurins

Li, Y., Lei, S., & Liu, Y. (2019) · ChemistrySelect · doi:10.1002/slct.201803597 · Cited by 18 · see citing works

The synthesis and biological evaluation of labelled karrikinolides for the elucidation of the mode of action of the seed germination stimulant

Scaffidi, A., Flematti, G. R., Nelson, D. C., Dixon, K. W., Smith, S. M., & Ghisalberti, E. L. (2010) · Tetrahedron · doi:10.1016/j.tet.2010.11.006 · Cited by 17 · see citing works

Modulation of the Mitochondrial Cytochrome bc1 Complex Activity by Chromanols and Related Compounds

Müllebner, A., Patel, A., Stamberg, W., et al. (2009) · Chemical Research in Toxicology · doi:10.1021/tx900333f · Cited by 17 · see citing works

Synthesis and biological activity of analogs of the antifungal antibiotic UK‐2A. III. Impact of modifications to the macrocycle isobutyryl ester position

OWEN, W. J., Meyer, K. G., Slanec, T. J., et al. (2019) · Pest Management Science · doi:10.1002/ps.5511 · Cited by 16 · see citing works

Synthetic Chromanol Derivatives and Their Interaction with Complex III in Mitochondria from Bovine, Yeast, and Leishmania

Monzote, L., Stamberg, W., Patel, A., et al. (2011) · Chemical Research in Toxicology · doi:10.1021/tx200233c · Cited by 15 · see citing works

Synthesis and Fungicidal Activity of (E)‐Methyl 2‐(2‐((1‐cyano‐2‐hydrocarbylidenehydrazinyl)methyl)phenyl)‐2‐(methoxyimino)acetates

Jia, C., Yuan, X., Liu, X., et al. (2019) · Pest Management Science · doi:10.1002/ps.5432 · Cited by 11 · see citing works

Approach Toward a Generic Treatment of Gram-Negative Infections: Synthesis of Haptens for Catalytic Antibody Mediated Cleavage of the Interglycosidic Bond in Lipid A

van den Berg, R. J. B. H. N., Noort, D., Milder‐Enacache, E. S., van der MAREL, G. A., BOOM, J. H. V., & Benschop, H. P. (1999) · European Journal of Organic Chemistry · doi:10.1002/(sici)1099-0690(199910)1999:10 · Cited by 10 · see citing works

Design, Synthesis and Bioactivities of Novel Strobilurin Derivatives Containing 1,3,4-Oxadiazole Moity

Liu, Y., Liu, M., Chen, M., et al. (2017) · Chinese Journal of Organic Chemistry · doi:10.6023/cjoc201607029 · Cited by 10 · see citing works

Synthesis and Evaluation of Essential Oil-Derived β-Methoxyacrylate Derivatives as High Potential Fungicides

Su, H., Wang, W., Bao, L., et al. (2017) · Molecules · doi:10.3390/molecules22050763 · Cited by 10 · see citing works

Design, Synthesis, and Antifungal Activities of New β‐Methoxyacrylate Analogues

Liu, H., Zhang, X., Gao, Y., et al. (2012) · Journal of the Chinese Chemical Society · doi:10.1002/jccs.201200295 · Cited by 9 · see citing works

Design and synthesis of potent inhibitors of bc1 complex based on natural product neopeltolide

Xiong, M., Chen, T., Wang, Y., et al. (2020) · Bioorganic & Medicinal Chemistry Letters · doi:10.1016/j.bmcl.2020.127324 · Cited by 9 · see citing works

Neighbouring-Group Assisted Thiazole-Ring Cleavage by DIBAL-H: An Expeditious Synthesis of Melithiazol C from Myxothiazol A

Söker, U., Sasse, F., Kunze, B., et al. (2000) · European Journal of Organic Chemistry · doi:10.1002/1099-0690(200006)2000:11 · Cited by 8 · see citing works

Synthesis and antifungal activities of novel strobilurin derivatives containing quinolin-2(1H)-one moiety

Liu, M., Liu, Y., Zhou, S., et al. (2016) · Chemical Research in Chinese Universities · doi:10.1007/s40242-016-6041-6 · Cited by 8 · see citing works

Synthesis and Fungicidal Activity of (E)‐α‐(Methoxyimino)benzeneacetate Derivatives Containing 1,2,4‐Triazole Schiff Base Side Chain

Song, H., & Shi, D. (2014) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.1795 · Cited by 8 · see citing works

Synthesis and evaluation of structural requirements for antifungal activity of cyrmenin B1 analogues

Chakor, N. S., Dallavalle, S., Musso, L., et al. (2011) · Tetrahedron Letters · doi:10.1016/j.tetlet.2011.11.023 · Cited by 6 · see citing works

Synthesis and antifungal potential of 1,2,3-triazole and 1,2,4-triazole thiol substituted strobilurin derivatives

Chaudhary, P. M., Tupe, S. G., Jorwekar, S. U., et al. (2015) · Cited by 6 · see citing works

Design, synthesis and fungicidal activity of novel strobilurin-1,2,4-triazole derivatives containing furan or thiophene rings

Liu, Y., Liu, M., Zhang, D., et al. (2016) · Chemical Research in Chinese Universities · doi:10.1007/s40242-016-6253-9 · Cited by 6 · see citing works

Synthesis and Fungicidal Activity of Strobilurin Analogues Containing 1,2,4‐Triazole Oxime Ether Moiety

Song, H., Song, H., & Shi, D. (2014) · Journal of Heterocyclic Chemistry · doi:10.1002/jhet.1708 · Cited by 5 · see citing works

Synthesis and Biological Activities of Some Novel (E)-Alpha-(methoxyimino)benzeneacetate Derivatives with Modified 1,2,4-Triazole Moiety

Wang, X., Wang, H., Chen, P., et al. (2014) · Journal of Chemistry · doi:10.1155/2014/681364 · Cited by 4 · see citing works

Lansoprazole interferes with fungal respiration and acts synergistically with amphotericin B against multidrug-resistant <i>Candida auris</i>

Salama, E. A., Elgammal, Y., Wijeratne, A., Lanman, N. A., Utturkar, S. M., Farhangian, A., Li, J., Meunier, B., Hazbun, T. R., & Seleem, M. N. (2024) · Emerging Microbes &amp; Infections · doi:10.1080/22221751.2024.2322649 · Cited by 16 · see citing works

The discovery of novel antifungal scaffolds by structural simplification of the natural product sampangine

Jiang, Z., Liu, N., Hu, D., et al. (2015) · Chemical Communications · doi:10.1039/c5cc05699c · Cited by 49 · see citing works

Bioactive Natural Product Discovery via Deuterium Adduct Bioactivity ScreeningPreprint

Zill, N. A., Du, Y., Marinkovich, S., et al. (2023) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2023.03.16.532988

Your natural product contains a promiscuous pains motif: Is it useful as a biochemical probe or in drug discovery?

Baell, J. B. (2015) · Planta Medica · doi:10.1055/s-0035-1556088

Unleashing the Potential of Microbial Natural Products in Drug Discovery: Focusing on Streptomyces as Antimicrobials Goldmine

Bansal, H., Singla, R. K., Behzad, S., et al. (2021) · Current Topics in Medicinal Chemistry · doi:10.2174/1568026621666210916170110 · Cited by 22 · see citing works

Bioactive Natural Product Discovery via Deuterium Adduct Bioactivity Screening

Zill, N. A., Du, Y., Marinkovich, S., Gu, D., Seidel, J. A., & Zhang, W. (2023) · ACS Chemical Biology · doi:10.1021/acschembio.3c00083 · Cited by 4 · see citing works