Cited by 243Alzheimer's disease research and treatmentsDementia and Cognitive Impairment ResearchNeuroinflammation and Neurodegeneration Mechanisms

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Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

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Ma, Chen, Hong, Fenfang, Yang, Shulong·2022·Molecules

DOI 10.3390/molecules27041210PMC PMC8876037

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Abstract

The amyloid hypothesis of Alzheimer’s disease has long been the predominant theory, suggesting that Alzheimer’s disease is caused by the accumulation of amyloid beta protein (Aβ) in the brain, leading to neuronal toxicity in the central nervous system (CNS). Because of breakthroughs in molecular medicine, the amyloid pathway is thought to be central to the pathophysiology of Alzheimer’s disease (AD). Currently, it is believed that altered biochemistry of the Aβ cycle remains a central biological feature of AD and is a promising target for treatment. This review provides an overview of the process of amyloid formation, explaining the transition from amyloid precursor protein to amyloid beta protein. Moreover, we also reveal the relationship between autophagy, cerebral blood flow, ACHE, expression of LRP1, and amyloidosis. In addition, we discuss the detailed pathogenesis of amyloidosis, including oxidative damage, tau protein, NFTs, and neuronal damage. Finally, we list some ways to treat AD in terms of decreasing the accumulation of Aβ in the brain.

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1 retracted

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Authors: Ma, C., Hong, F., & Yang, S.
Affiliations: Nanchang University (CN)
Experimental Center of Pathogen Biology, Nanchang University, Nanchang 330006, China
Department of Physiology, College of Medicine, Nanchang University, Nanchang 330006, China
ORCID: Ma, Chen
Venue: Molecules
Publisher: MDPI AG
Published: 2022-02-11
Volume: 27
Issue: 4
Pages: 1210
ISSN: 1420-3049 (ISSN-L)
DOI: 10.3390/molecules27041210
PMC: PMC8876037
OpenAlex: W4212889165
Cited by: 243
References: 83
Citations by year: 2026: 51 · 2025: 80 · 2024: 65 · 2023: 36 · 2022: 11
FWCI: 6.60
Type: journal article
Language: en
Open access: gold
doi.org
Licence: cc-by
creativecommons.org/licenses/by/4.0/ (vor)
Locations: Molecules (publishedVersion, cc-by)
PubMed Central (publishedVersion, cc-by)
PubMed (publishedVersion)
DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders: the National Natural Science Foundation of China (82060661,81660151 and 81660751)
Topics: Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Alzheimer's disease research and treatments
Health Sciences › Medicine › Psychiatry and Mental health › Dementia and Cognitive Impairment Research
Life Sciences › Neuroscience › Neurology › Neuroinflammation and Neurodegeneration Mechanisms
Keywords: Alzheimer's disease, amyloidosis, amyloid hypothesis, amyloid-beta, amyloid precursor protein, amyloid fibril formation, autophagy, cerebral blood flow, acetylcholinesterase, LRP1, oxidative damage, tau protein, neurofibrillary tangles, neuronal injury, Alzheimer's disease treatment
MeSH terms: Alzheimer Disease, Amyloid, Amyloidosis, Animals, Autophagy, Brain, Disease Susceptibility, Gene Expression Regulation, Humans, Risk Factors, Biomarkers, Amyloid beta-Peptides, Disease Management, Plaque, Amyloid

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Amyloidosis in Alzheimer’s Disease: Pathogeny, Etiology, and Related Therapeutic Directions

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