Photodynamic Inactivation of Microorganisms Using Semisynthetic Chlorophyll a Derivatives as Photosensitizers
Open accessAbstract
In this study, we describe the semisynthesis of cost-effective photosensitizers (PSs) derived from chlorophyll a containing different substituents and using previously described methods from the literature. We compared their structures when used in photodynamic inactivation (PDI) against Staphylococcus aureus, Escherichia coli, and Candida albicans under different conditions. The PSs containing carboxylic acids and butyl groups were highly effective against S. aureus and C. albicans following our PDI protocol. Overall, our results indicate that these nature-inspired PSs are a promising alternative to selectively inactivate microorganisms using PDI.
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Chlorophyll derivatives containing carboxylic acids and butyl groups were highly effective against Staphylococcus aureus and Candida albicans, showing significant toxic effects at 10 μM and a light dose of 15 Jcm−2 at 660 nm.
“The PSs containing carboxylic acids and butyl groups were highly effective against both microorganisms, showing significant toxic effects at a concentration of 10 µM and a light dose of 15 Jcm−2 and 660 nm.”
From Emerging Applications of Chlorella sp. and Spirulina (Arthrospira) sp. (2023) · cites this paper as [146]
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- Authors
- Uliana, M. P., da Cruz Rodrigues, A., Ono, B. A., Pratavieira, S., de Oliveira, K. T., & Kurachi, C.
- Affiliations
- Universidade Federal da Integração Latino-Americana (BR)
- Universidade Federal da Integração Latino-Americana, Foz do Iguaçu CEP 85866-000, Brazil
- Universidade de São Paulo (BR)
- Departamento de Química, Universidade Federal de São Carlos, Rodovia Washington Luís, km 235-SP-310, São Carlos, São Paulo CEP 13565-905, Brazil
- Corresponding author
- Uliana, Marciana Pierina
- Venue
- Molecules
- Publisher
- MDPI AG
- Published
- 2022-09-06
- Volume
- 27
- Issue
- 18
- Pages
- 5769
- ISSN
- 1420-3049 (ISSN-L)
- PMC
- PMC9653790
- OpenAlex
- W4296808683
- Cited by
- 16
- References
- 69
- Citations by year
- 2026: 3 · 2025: 4 · 2024: 4 · 2023: 5
- FWCI
- 2.10
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Molecules (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- FAPESP (São Paulo Research Foundation) (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- EMU (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- CEPOF (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- KTO (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- PRPPG-UNILA (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- CNPq (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- CAPES (2013/06532-4, 2011/19720-8, 2011/13993-2, 2008/57858-9, 2009/54035-4, 2013/07276-1, 2019/27176-8, 2020/06874-6, 80/2019/PRPPG, 104/2020/PRPPG, 105/2020/PRPPG, 465360/2014-9, 306919/2019-2)
- Topics
- Health Sciences › Medicine › Pulmonary and Respiratory Medicine › Photodynamic Therapy Research Studies
- Physical Sciences › Materials Science › Materials Chemistry › Porphyrin and Phthalocyanine Chemistry
- Physical Sciences › Chemistry › Organic Chemistry › Antimicrobial agents and applications
- Keywords
- photodynamic inactivation, photosensitizers, chlorophyll a, Staphylococcus aureus, Escherichia coli, Candida albicans, antimicrobial activity, carboxylic acid substituents, butyl substituent
- MeSH terms
- Chlorophyll A, Candida albicans, Carboxylic Acids, Escherichia coli, Photochemotherapy, Staphylococcus aureus, Photosensitizing Agents
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
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