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Cited by 706

The DOI matches its Crossref record; 142 of the 142 references it cites were found in a registry or an index.

Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids

Open access
Rogero, Marcelo, Calder, Philip·2018·Nutrients
DOI 10.3390/nu10040432
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Abstract

Obesity leads to an inflammatory condition that is directly involved in the etiology of cardiovascular diseases, type 2 diabetes mellitus, and certain types of cancer. The classic inflammatory response is an acute reaction to infections or to tissue injuries, and it tends to move towards resolution and homeostasis. However, the inflammatory process that was observed in individuals affected by obesity and metabolic syndrome differs from the classical inflammatory response in certain respects. This inflammatory process manifests itself systemically and it is characterized by a chronic low-intensity reaction. The toll-like receptor 4 (TLR4) signaling pathway is acknowledged as one of the main triggers of the obesity-induced inflammatory response. The aim of the present review is to describe the role that is played by the TLR4 signaling pathway in the inflammatory response and its modulation by saturated and omega-3 polyunsaturated fatty acids. Studies indicate that saturated fatty acids can induce inflammation by activating the TLR4 signaling pathway. Conversely, omega-3 polyunsaturated fatty acids, such as eicosapentaenoic acid and docosahexaenoic acid, exert anti-inflammatory actions through the attenuation of the activation of the TLR4 signaling pathway by either lipopolysaccharides or saturated fatty acids.

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Metadata

Authors
Rogero, M., & Calder, P.
Venue
Nutrients
Publisher
MDPI AG
Published
2018-03-30
Volume
10
Issue
4
Pages
432
ISSN
2072-6643 (ISSN-L)
DOI
10.3390/nu10040432
OpenAlex
W2794942947
Cited by
706
References
142
FWCI
47.41
Type
journal article
Language
en
Open access
gold

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CoChat. (2026). Citation check: Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids. https://app.cochat.ai/papers/10.3390/nu10040432
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Rogero, M., & Calder, P. (2018). Obesity, Inflammation, Toll-Like Receptor 4 and Fatty Acids. Nutrients. https://doi.org/10.3390/nu10040432

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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