Cited by 89Gastrointestinal motility and disordersGut microbiota and healthMicrobial Metabolites in Food Biotechnology

Effect of Repeated Consumption of Partially Hydrolyzed Guar Gum on Fecal Characteristics and Gut Microbiota: A Randomized, Double-Blind, Placebo-Controlled, and Parallel-Group Clinical Trial

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Yasukawa, Zenta, Inoue, Ryo, Ozeki, Makoto, Okubo, Tsutomu, Takagi, Tomohisa, Honda, Akira, Naito, Yuji·2019·Nutrients

Abstract

Partially hydrolyzed guar gum (PHGG) is a water-soluble dietary fiber and is used in solid and liquid food to regulate gut function. The aim of this study was to investigate effects of PHGG on bowel movements (stool form and frequency), plasma bile acids, quality of life, and gut microbiota of healthy volunteers with a tendency toward diarrhea, i.e., irritable bowel syndrome diarrhea (IBS-D)-like symptoms. A randomized, double-blind, placebo-controlled, and parallel trial was performed on 44 healthy volunteers (22 males, 22 females, 41.9 ± 6.3 years old (average ± SD)) with minimum 7 bowel movements every week, wherein above 50% of their stool was between the Bristol stool scale (BSS) value of 5 and 6. Intake of the PHGG for 3 months significantly improved stool form, evaluated using BSS, and had no effects on stool frequency. BSS was significantly normalized in the group consuming the PHGG compared with the placebo. Comprehensive fecal microbiome analysis by the 16S rRNA-sequence method detected significant changes in the ratio of some bacteria, such as an increase of Bifidobacterium (p < 0.05) in the PHGG group. Our results suggest that intake of PHGG improves human stool form via regulating intestinal microbiota.

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Authors
Yasukawa, Z., Inoue, R., Ozeki, M., Okubo, T., Takagi, T., Honda, A., & Naito, Y.
Affiliations
  • Mie University (JP)
  • Laboratory of Animal Science, Department of Agricultural and Life Sciences, Kyoto Prefectural University, Kyoto 606-8522, Japan
  • Nutrition Division, Taiyo Kagaku Co., Ltd., Yokkaichi, Mie 510-0844, Japan
  • Kyoto Prefectural University of Medicine (JP)
  • Tokyo Medical University Ibaraki Medical Center (JP)
Corresponding author
Yasukawa, Zenta
Venue
Nutrients
Publisher
MDPI AG
Published
2019-09-10
Volume
11
Issue
9
Pages
2170
ISSN
2072-6643 (ISSN-L)
OpenAlex
W2972749741
Cited by
89
References
6
Citations by year
2026: 12 · 2025: 20 · 2024: 15 · 2023: 15 · 2022: 13 · 2021: 8 · 2020: 6
FWCI
6.15
Type
journal article
Language
en
Open access
Locations
  • Nutrients (publishedVersion, cc-by)
  • Europe PMC (PubMed Central) (publishedVersion, cc-by)
  • PubMed Central (publishedVersion, cc-by)
  • PubMed (publishedVersion)
  • DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
Funders
Ministry of Agriculture, Forestry and Fisheries
Topics
  • Health Sciences › Medicine › Gastroenterology › Gastrointestinal motility and disorders
  • Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Gut microbiota and health
  • Health Sciences › Nursing › Nutrition and Dietetics › Microbial Metabolites in Food Biotechnology
Keywords
partially hydrolyzed guar gum, dietary fiber, stool consistency, stool frequency, gut microbiota, Bifidobacterium, plasma bile acids, quality of life, Bristol stool scale, healthy volunteers
MeSH terms
Gastrointestinal Microbiome, Adult, Bacteria, Bile Acids and Salts, Defecation, Diarrhea, Dietary Fiber, Double-Blind Method, Feces, Female, Galactans, Humans, Hydrolysis, Male, Mannans, Middle Aged, Quality of Life, Time Factors, Tokyo, Treatment Outcome, Plant Gums, Young Adult, Prebiotics

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