Nicotinamide-Rich Diet in DBA/2J Mice Preserves Retinal Ganglion Cell Metabolic Function as Assessed by PERG Adaptation to Flicker
Open accessAbstract
Flickering light increases metabolic demand in the inner retina. Flicker may exacerbate defective mitochondrial function in glaucoma, which will be reflected in the pattern electroretinogram (PERG), a sensitive test of retinal ganglion cell (RGC) function. We tested whether flicker altered the PERG of DBA/2J (D2) glaucomatous mice and whether vitamin B3-rich diet contributed to the flicker effect. D2 mice fed with either standard chow (control, n = 10) or chow/water enriched with nicotinamide (NAM, 2000 mg/kg per day) (treated, n = 10) were monitored from 3 to 12 months. The PERG was recorded with superimposed flicker (F-PERG) at either 101 Hz (baseline) or 11 Hz (test), and baseline-test amplitude difference (adaptation) evaluated. At endpoint, flat-mounted retinas were immunostained (RBPMS and mito-tracker). F-PERG adaptation was 41% in 3-month-old D2 and decreased with age more in control D2 than in NAM-fed D2 (GEE, p < 0.01). At the endpoint, F-PERG adaptation was 0% in control D2 and 17.5% in NAM-fed D2, together with higher RGC density (2.4×), larger RGC soma size (2×), and greater intensity of mitochondrial staining (3.75×). F-PERG adaptation may provide a non-invasive tool to assess RGC autoregulation in response to increased metabolic demand and test the effect of dietary/pharmacological treatments on optic nerve disorders.
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Deficiencies in B vitamins are implicated in retinitis pigmentosa and glaucoma.
“Deficiencies in B vitamins are implicated in retinitis pigmentosa and glaucoma, for which improved outcomes can be achieved by dietary supplementation [24, 114].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [24]
Improved outcomes in retinitis pigmentosa and glaucoma can be achieved by dietary supplementation.
“Deficiencies in B vitamins are implicated in retinitis pigmentosa and glaucoma, for which improved outcomes can be achieved by dietary supplementation [24, 114].”
From Fecal microbiota transfer between young and aged mice reverses hallmarks of the aging gut, eye, and brain (2022) · cites this paper as [24]
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- Authors
- Chou, T.-H., Romano, G. L., Amato, R., & Porciatti, V.
- Affiliations
- University of Miami (US)
- University of Pisa (IT)
- Corresponding author
- Chou, Tsung-Han
- Venue
- Nutrients
- Publisher
- MDPI AG
- Published
- 2020-06-27
- Volume
- 12
- Issue
- 7
- Pages
- 1910
- ISSN
- 2072-6643 (ISSN-L)
- PMC
- PMC7401244
- OpenAlex
- W3037601476
- Cited by
- 57
- References
- 23
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 4 · 2023: 13 · 2022: 18 · 2021: 17 · 2020: 1
- FWCI
- 9.71
- Type
- journal article
- Language
- en
- Open access
- gold
- dx.doi.org
- Licence
- Locations
- Nutrients (publishedVersion, cc-by)
- PubMed Central (publishedVersion, cc-by)
- PubMed (publishedVersion)
- CINECA IRIS Institutial research information system (University of Pisa) (submittedVersion, other-oa)
- DOAJ (DOAJ: Directory of Open Access Journals) (submittedVersion, cc-by-sa)
- Funders
- National Institutes of Health (RO1 EY019077, P30EY014801)
- Research to Prevent Blindness (Unrestricted Grant)
- Topics
- Health Sciences › Medicine › Ophthalmology › Glaucoma and retinal disorders
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Retinal Development and Disorders
- Health Sciences › Medicine › Geriatrics and Gerontology › Sirtuins and Resveratrol in Medicine
- Keywords
- nicotinamide, nicotinic acid, dietary supplementation, glaucoma, DBA/2J mice, retinal ganglion cells, pattern electroretinogram, retinal metabolism, mitochondrial function, optic nerve
- MeSH terms
- Adaptation, Physiological, Animals, Disease Models, Animal, Electroretinography, Glaucoma, Mice, Inbred DBA, Niacinamide, Photic Stimulation, Retina, Retinal Ganglion Cells, Dietary Supplements, Mice
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