Glaucoma as a Metabolic Optic Neuropathy: Making the Case for Nicotinamide Treatment in Glaucoma

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Nicotinamide and WLDS Act Together to Prevent Neurodegeneration in Glaucoma

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Metabolic Vulnerability in the Neurodegenerative Disease Glaucoma

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Use of calcium channel blockers for glaucoma

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Protection of Mouse Retinal Ganglion Cell Axons and Soma from Glaucomatous and Ischemic Injury by Cytoplasmic Overexpression of Nmnat1

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OPA1 increases the risk of normal but not high tension glaucoma

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Role of the ETBreceptor in retinal ganglion cell death in glaucomaThis article is one of a selection of papers published in the special issue (part 1 of 2) on Forefronts in Endothelin.

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Association of primary open-angle glaucoma with mitochondrial variants and haplogroups common in African Americans.

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Silencing of Fem1c R3 Gene Expression in the DBA/2J Mouse Precedes Retinal Ganglion Cell Death and Is Associated with Histone Deacetylase Activity

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Whole-mitochondrial genome sequencing in primary open-angle glaucoma using massively parallel sequencing identifies novel and known pathogenic variants

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Apelin-13 attenuates optic nerve damage in glaucomatous mice by regulating glucose metabolism

Zhang, Y., Zhao, J., Zhou, J., Jiang, Z., Cheng, K., Lei, C., & Yu, L. (2025) · Journal of Translational Medicine · doi:10.1186/s12967-025-06212-z · Cited by 8 · see citing works

Targeting Neuroinflammation and Oxidative Stress to Slow Neurodegeneration in the Visual System

Shakaki, N., & Yu, M. (2026) · Journal of Clinical Medicine · doi:10.3390/jcm15093254 · Cited by 7 · see citing works

Of axons that struggle to make ends meet: Linking axonal bioenergetic failure to programmed axon degeneration

Babetto, E., & Beirowski, B. (2022) · Biochimica et Biophysica Acta (BBA) - Bioenergetics · doi:10.1016/j.bbabio.2022.148545 · Cited by 7 · see citing works

Neuroprotection beyond intraocular pressure: game changer or quiet addiction

Grosso, A., Borrelli, E., Sacchi, M., Calzetti, G., Ceruti, P., Neri, G., Marchetti, M., Pinna, A., Костин, В. В., Reibaldi, M., et al. (2025) · Graefe s Archive for Clinical and Experimental Ophthalmology · doi:10.1007/s00417-025-06816-7 · Cited by 7 · see citing works

Nicotinamide and Pyruvate in Open-Angle Glaucoma

Shukla, A. G., Tsamis, E., Moraes, C. G. D., John, S. W. M., Hood, D. C., Goldberg, J. L., Hark, L. A., Atakulova, M., Wang, Y., Greenfield, D. S., et al. (2025) · Ophthalmology Glaucoma · doi:10.1016/j.ogla.2025.12.008 · Cited by 6 · see citing works

An Exploratory Study of Six-Month Niacinamide Supplementation on Macular Structure and Electrophysiology in Primary Open-Angle Glaucoma

Nicola, C. A., Marinescu, M. C., Alexandrescu, C. M., Firan, A. M., Alyamani, W., Naidin, M.-S., Ciuluvica, R. C., Patrascu, R. A., Căpraru, A.-M., & Turcu-Ştiolică, A. (2026) · Vision · doi:10.3390/vision10010007 · Cited by 5 · see citing works

Association between dietary niacin and retinal nerve fibre layer thickness in healthy eyes of different ages

Charng, J., Ansari, A. S., Bondonno, N. P., Hunter, M. L., O’Sullivan, T. A., Louca, P., Hammond, C. J., & Mackey, D. A. (2022) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14120 · Cited by 5 · see citing works

Pharmacological restoration of impaired autophagy in retinal ganglion cells prevents abnormal mitochondrial accumulation and glaucomatous neurodegeneration

Maddineni, P., Kaipa, B. R., Kodati, B., Kesavan, K., Li, L., Millar, J. C., Yacoub, S., Kasetti, R. B., Clark, A. F., & Zode, G. S. (2026) · Molecular Neurodegeneration · doi:10.1186/s13024-026-00950-4 · Cited by 4 · see citing works

Prospects for Neuroprotective Therapies in Glaucoma: Drug Targets and Emerging Clinical Strategies

Rho, S., & Williams, P. A. (2026) · Drug Design Development and Therapy · doi:10.2147/dddt.s612176 · Cited by 3 · see citing works

Retinal ischemic diseases and promising therapeutic molecular targets.

Lee, D., Tomita, Y., Negishi, K., & Kurihara, T. (2025) · PubMed · doi:10.14670/hh-18-756 · Cited by 3 · see citing works

Oral pyruvate prevents glaucomatous neurodegenerationPreprint

Williams, P. A., Harder, J. M., Guymer, C., Wood, J. P. M., Daskalaki, E., Chidlow, G., Cardozo, B. H., Foxworth, N. E., Cochran, K. E., Ouellette, T. B., et al. (2020) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2020.05.02.072215 · Cited by 3 · see citing works

NAD+ and Sirt5 restore mitochondrial bioenergetics failure and improve locomotor defects caused by sucla2 mutations

Richard, J., Lizzo, G., Rochat, N., Jouary, A., Silva, P. T., Parisi, A., Christen, S., Moco, S., Orger, M. B., & Gut, P. (2026) · JCI Insight · doi:10.1172/jci.insight.181812 · Cited by 2 · see citing works

The mitochondria-targeted peptide HDAP2 reduces mitochondrial loss and retinal ganglion cell degeneration after optic nerve injury

MacNeil, M. A., Arain, S., Mentor, W., García‐Marín, V., & Birk, A. V. (2026) · Neuroscience · doi:10.1016/j.neuroscience.2026.01.045 · Cited by 2 · see citing works

“Doctor, what else can I do for my glaucoma?” Exercise, nicotinamide and other lifestyle interventions

Crowston, J. G., Chrysostomou, V., & Bell, K. C. (2023) · Clinical and Experimental Ophthalmology · doi:10.1111/ceo.14241 · Cited by 2 · see citing works

Pyrroloquinoline Quinone Targets the Allosteric Activation Site of Nicotinamide Phosphoribosyltransferase (NAMPT): Structural Basis and Consequences for NAD+ Metabolism in Aging

Medoro, A., Davinelli, S., Jafar, T. H., Trung, T. T., Costagliola, C., Rossi, G. C. M., & Scapagnini, G. (2026) · Applied Sciences · doi:10.3390/app16136695 · Cited by 1 · see citing works

Nicotinamide Supplementation and Primary Open-Angle Glaucoma in Patients With Ocular Hypertension

Muayad, J., Sallam, A. B., Francesco, T. D., Moraes, C. G. D., & Ahmed, I. I. K. (2026) · JAMA Ophthalmology · doi:10.1001/jamaophthalmol.2026.2472 · Cited by 1 · see citing works

TLR4 deficiency does not alter glaucomatous progression in a mouse model of chronic glaucoma

Zhang, C., Simón, M., Harder, J. M., Lim, H., Montgomery, C. L., Wang, Q., & John, S. W. M. (2025) · Scientific Reports · doi:10.1038/s41598-025-00638-7 · Cited by 1 · see citing works

Nutritional Medicine: The Power of Nutrients to Prevent Disease and Optimize Health

Gaby, A. R. (2020) · Alternative and Complementary Therapies · doi:10.1089/act.2020.29281.aga

Descriptive epidemiological study of glaucoma in the Far Eastern Federal District covering the years 2012 to 2019

Догадова, Л. П., Гиренок, Е. В., Маркелова, Е. В., & Melnikov, V. Y. (2021) · National Journal glaucoma · doi:10.53432/2078-4104-2021-20-2-23-29

Various forms of glaucoma and their treatments

Sharif, N. A. (2022) · Elsevier eBooks · doi:10.1016/b978-0-12-819291-7.00032-0

Optic Nerve and Retinal Ganglion Cell Protection, Rejuvenation, and Regeneration as Glaucoma Treatment Strategies

Sharif, N. A. (2022) · IntechOpen eBooks · doi:10.5772/intechopen.108914

An Overview of Dietary Approaches to Prevent the Development of Glaucoma

Kapur, P., Ashok, P., Gupta, S., Bhardwaj, M., & Suri, M. (2020) · The Indian Journal of Nutrition and Dietetics · doi:10.21048/ijnd.2020.57.3.23638

Inflammatory and immunological aspects of glaucoma, optic neuritis, and neuromyelitis optica impacting eyesight

Sharif, N. A. (2023) · Elsevier eBooks · doi:10.1016/b978-0-323-85841-0.00018-3

Prospects for neuroretinoprotective therapy of glaucoma

Апрелев, А. Е., & Sukmanyu, E. O. (2023) · Russian Ophthalmological Journal · doi:10.21516/2072-0076-2023-16-4-147-151

Mitochondria and Primary Open Angle Glaucoma

Williams, P. A., & Hui, F. (2024) · Elsevier eBooks · doi:10.1016/b978-0-443-13820-1.00103-1

Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for GlaucomaPreprint

Li, K., Tolman, N. G., Segrè, A. V., Stuart, K. V., Zeleznik, O. A., Vallabh, N. A., Hu, K., Zebardast, N., Hanyuda, A., Raita, Y., et al. (2025) · eLife · doi:10.7554/elife.105576.1

Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for GlaucomaPreprint

Li, K., Tolman, N. G., Segrè, A. V., Stuart, K. V., Zeleznik, O. A., Vallabh, N. A., Hu, K., Zebardast, N., Hanyuda, A., Raita, Y., et al. (2025) · eLife · doi:10.7554/elife.105576.2

Author response: Pyruvate and Related Energetic Metabolites Modulate Resilience Against High Genetic Risk for Glaucoma

Li, K., Tolman, N. G., Segrè, A. V., Stuart, K. V., Zeleznik, O. A., Vallabh, N. A., Hu, K., Zebardast, N., Hanyuda, A., Raita, Y., et al. (2025) · eLife · doi:10.7554/elife.105576.2.sa0

eLife Assessment: Pyruvate and related energetic metabolites modulate resilience against high genetic risk for glaucoma

Bernstein, A. M. (2025) · eLife · doi:10.7554/elife.105576.3.sa0

Inferring systemic metabolic and oxidative stress susceptibility in normal-tension glaucoma through targeted skin fibroblast analysisPreprint

von Spreckelsen, A., Dittlau, K. S., Saruhanian, S., Vohra, R., Saruhanian, A., Aldana, B. I., Freude, K., & Kolko, M. (2025) · bioRxiv (Cold Spring Harbor Laboratory) · doi:10.1101/2025.09.21.677625

Additional file 1 of AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

Belforte, N., Agostinone, J., Alarcón-Martínez, L., Villafranca‐Baughman, D., Dotigny, F., Vargas, J. C., & Polo, A. D. (2021) · Figshare · doi:10.6084/m9.figshare.14880590

Additional file 2 of AMPK hyperactivation promotes dendrite retraction, synaptic loss, and neuronal dysfunction in glaucoma

Belforte, N., Agostinone, J., Alarcón-Martínez, L., Villafranca‐Baughman, D., Dotigny, F., Vargas, J. C., & Polo, A. D. (2021) · Figshare · doi:10.6084/m9.figshare.14880593

Nicotinamide treatment robustly protects from inherited mouse glaucoma

Williams, P. A., Harder, J. M., Cardozo, B. H., Foxworth, N. E., & John, S. W. M. (2018) · Communicative & Integrative Biology · doi:10.1080/19420889.2017.1356956 · Cited by 96 · see citing works

Nicotinamide provides neuroprotection in glaucoma by protecting against mitochondrial and metabolic dysfunction

Tribble, J. R., Otmani, A., Sun, S., Ellis, S. A., Cimaglia, G., Vohra, R., Jöe, M., Lardner, E., Venkataraman, A. P., Domínguez‐Vicent, A., et al. (2021) · Redox Biology · doi:10.1016/j.redox.2021.101988 · Cited by 233 · see citing works

Update on Nicotinamide and Its Application in the Management of Glaucoma

Chiu, T.-H., Hung, S.-H., Lan, C., Yen, W., & Lu, D. (2025) · International Journal of Molecular Sciences · doi:10.3390/ijms262110789 · Cited by 9 · see citing works

Nicking Glaucoma with Nicotinamide?

Liebmann, J. M., & Cioffi, G. A. (2017) · New England Journal of Medicine · doi:10.1056/nejmcibr1702486 · Cited by 21 · see citing works

Neuroproteção no glaucoma além da redução da pressão intraocular: novas evidências sobre nicotinamida, metabolismo mitocondrial e sobrevivência das células ganglionares

Grimm, M. E. J., Nunes, A. C., Carvalho, I. C. D. M. R., Muniz, T. V. H., de Alencar, C. E. M., Silva, E. D. S. A., Medeiros, M. V. R., Melo, J. V. A. S. N. D., Tomé, R. F. F., Júnior, C. H. L., et al. (2026) · Cadernos Cajuína · doi:10.52641/cadcajv11i13.4066